RGD Reference Report - Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. - Rat Genome Database

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Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus.

Authors: Goto, F  Saruta, J  Kanzaki, S  To, M  Tsutsumi, T  Tsukinoki, K  Ogawa, K 
Citation: Goto F, etal., Neurosci Lett. 2012 Feb 29;510(2):73-7. doi: 10.1016/j.neulet.2012.01.001. Epub 2012 Jan 17.
RGD ID: 8655556
Pubmed: PMID:22281446   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2012.01.001   (Journal Full-text)

OBJECTIVE: Thus far, no objective measure has been developed to evaluate tinnitus severity. There is a close relationship between tinnitus and depression, in which brain-derived neurotrophic factor (BDNF) has a pathophysiological role. To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus. METHODS: Plasma BDNF levels were measured in 43 tinnitus patients and 30 healthy control patients. The severities of tinnitus, depression, and anxiety were measured using the tinnitus handicap inventory (THI) and the hospital anxiety and depression scale (HADS), respectively. Patients with tinnitus were divided into 2 groups depending on their THI scores: mildly handicapped (<36) and severely handicapped (>38). We also divided our subjects into 2 groups depending on the HADS score, which represents patient mood, including depression and anxiety. RESULTS: Plasma BDNF levels were significantly higher in the mildly handicapped group than in the severely handicapped and control groups (P<0.01). Patients with HADS scores of

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Tinnitus severityIEP 8655556 RGD 
Tinnitus severityISOBDNF (Homo sapiens)8655556; 8655556 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)


Additional Information