RGD Reference Report - Platelet and plasma BDNF in lower respiratory tract infections of the adult. - Rat Genome Database

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Platelet and plasma BDNF in lower respiratory tract infections of the adult.

Authors: Lommatzsch, M  Niewerth, A  Klotz, J  Schulte-Herbruggen, O  Zingler, C  Schuff-Werner, P  Virchow, JC 
Citation: Lommatzsch M, etal., Respir Med. 2007 Jul;101(7):1493-9. Epub 2007 Feb 20.
RGD ID: 4891069
Pubmed: PMID:17317133   (View Abstract at PubMed)
DOI: DOI:10.1016/j.rmed.2007.01.003   (Journal Full-text)

Enhanced bronchial responsiveness during and following lower respiratory tract infections is a major clinical problem, but its pathogenesis is poorly understood. Brain-derived neurotrophic factor (BDNF), which can be released by platelets and leukocytes, has been identified as a mediator of bronchial hyperresponsiveness. It is unknown whether the release of BDNF is altered during lower respiratory tract infections of the adult. In this clinical pilot study, 16 patients (35-80 years old) with the diagnosis of an acute bacterial lower respiratory tract infection and elevated serum concentrations of c-reactive protein (>100 microg/ml) and procalcitonin (>0.1 ng/ml) were examined on admission to the hospital and 1 week after antibiotic treatment. Sixteen age- and sex-matched controls were examined in the same time period. BDNF concentrations in serum and platelets, but not in plasma, were markedly reduced in patients on the day of admission (median <25% of the controls). Analysis of the platelet marker serotonin (5-HT) suggested that the decrease of platelet BDNF is part of a non-specific release of platelet-derived mediators in this condition. Clinical improvement was accompanied by a restoration of serum and platelet BDNF concentrations which returned to control levels after 1 week of treatment. Cell culture experiments revealed that bacterial lipopolysaccharide (LPS) enhanced the release of BDNF by peripheral blood mononuclear cells of the patients at both time points. In conclusion, these data suggest that lower respiratory tract infections might be associated with an augmented release of BDNF by platelets and mononuclear cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Respiratory Tract Infections  IEP 4891069protein:decreased expression:platelet and serumRGD 
Respiratory Tract Infections  ISOBDNF (Homo sapiens)4891069; 4891069protein:decreased expression:platelet and serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)


Additional Information