RGD Reference Report - Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. - Rat Genome Database

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Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease.

Authors: Sun, M  Kong, L  Wang, X  Lu, XG  Gao, Q  Geller, AI 
Citation: Sun M, etal., Brain Res. 2005 Aug 9;1052(2):119-29.
RGD ID: 8657066
Pubmed: PMID:16018990   (View Abstract at PubMed)
PMCID: PMC2581863   (View Article at PubMed Central)
DOI: DOI:10.1016/j.brainres.2005.05.072   (Journal Full-text)

Both glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) can protect nigrostriatal dopaminergic neurons from neurotoxins in rodent and monkey models of Parkinson's disease (PD). These two neurotrophic factors are usually tested individually. This study was designed to compare GDNF, BDNF, or both, for their capabilities to correct behavioral deficits and protect nigrostriatal dopaminergic neurons in a rat model of PD. Gene transfer used a helper virus-free Herpes Simplex Virus (HSV-1) vector system and a modified neurofilament heavy gene promoter that supports long-term expression in forebrain neurons. Rats received unilateral intrastriatal injections of HSV-1 vectors that express either GDNF or BDNF, or both vectors, followed by intrastriatal injections of 6-hydroxydopamine (6-OHDA). Recombinant GDNF or BDNF was detected in striatal neurons in rats sacrificed at 7 months after gene transfer. Of note, GDNF was significantly more effective than BDNF for both correcting behavioral deficits and protecting nigrostriatal dopaminergic neurons. Expression of both neurotrophic factors was no more effective than expression of only GDNF. These results suggest that GDNF is more effective than BDNF for correcting the rat model of PD, and that there are no detectable benefits from expressing both of these neurotrophic factors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinsonism treatmentIDA 8657066; 8657066 RGD 
Parkinsonism treatmentISOBDNF (Homo sapiens)8657066; 8657066 RGD 
Parkinsonism treatmentISOGDNF (Homo sapiens)8657066; 8657066 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)
Gdnf  (glial cell derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)
Gdnf  (glial cell line derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)
GDNF  (glial cell derived neurotrophic factor)


Additional Information