RGD Reference Report - The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.

General

The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.
Authors:	Liu, L Zhang, X Wang, L Yang, R Cui, L Li, M Du, W Wang, S
Citation:	Liu L, etal., Brain Res Bull. 2010 May 31;82(3-4):228-33. Epub 2010 Apr 24.
RGD ID:	4891138
Pubmed:	PMID:20417695 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.brainresbull.2010.04.005 (Journal Full-text)
The activation of cAMP response element binding protein (CREB) and transcription of CRE-targeted genes play critical roles in various physiological and pathological conditions. Transducers of regulated CREB activity (TORCs) represent a new family of conserved CREB coactivators that promote the activation of CRE-targeted genes. Tanshinone IIA (TSA) has been proven to protect the brain against focal ischemia injury. However, little is known regarding the underlying mechanisms. Herein, we examined the activity-dependent nuclear translocation of TORC1 (transducer of regulated CREB activity 1) and the expression of TORC1, phosphorylated CREB (pCREB) and BDNF (brain-derived neurotrophic factor) at the early time of ischemic stroke as well as after the treatment with TSA. We observed a bimodal increase in pCREB, TORC1 and BDNF protein levels and transient nuclear accumulation of TORC1 in the acute stage of ischemia. Compared with vehicle group, TSA (20mg/kg) dramatically lessened neurological deficits scores, brain water contents and infarct sizes, significantly enhanced nuclear accumulation of TORC1 and upregulated the expression of TORC1, pCREB and BDNF (P<0.05). Collectively, the present results suggest that TSA protects rat brain from pristine ischemic damage in cerebral cortex, which might be correlated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
middle cerebral artery infarction	treatment	ISO	Bdnf (Rattus norvegicus)	4891138; 4891138		RGD
middle cerebral artery infarction	treatment	IEP		4891138; 4891138		RGD
middle cerebral artery infarction	treatment	ISO	Crtc1 (Rattus norvegicus)	4891138; 4891138		RGD

Objects Annotated

Genes (Rattus norvegicus)

Bdnf (brain-derived neurotrophic factor)

Crtc1 (CREB regulated transcription coactivator 1)

Genes (Mus musculus)

Bdnf (brain derived neurotrophic factor)

Crtc1 (CREB regulated transcription coactivator 1)

Genes (Homo sapiens)

BDNF (brain derived neurotrophic factor)

CRTC1 (CREB regulated transcription coactivator 1)

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The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.