RGD Reference Report - Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior. - Rat Genome Database

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Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior.

Authors: Hughes, MS  Shenoy, M  Liu, L  Colak, T  Mehta, K  Pasricha, PJ 
Citation: Hughes MS, etal., Pancreas. 2011 May;40(4):551-6. doi: 10.1097/MPA.0b013e318214fb77.
RGD ID: 8657093
Pubmed: PMID:21499209   (View Abstract at PubMed)
PMCID: PMC4090218   (View Article at PubMed Central)
DOI: DOI:10.1097/MPA.0b013e318214fb77   (Journal Full-text)

OBJECTIVES: We examined the role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of pain in an experimental model of chronic pancreatitis (CP). METHODS: Pancreatitis was induced by retrograde infusion of trinitrobenzene sulfonic acid into the pancreatic duct of adult rats. Twenty-one days after injection, BDNF expression was examined in pancreas-specific dorsal root ganglia (DRGs) by immunohistochemistry, and protein levels were quantified from DRGs and spinal cord extracts. The effects of intrathecal infusion of a neutralizing antibody to BDNF on pancreatic hyperalgesia were assessed by the sensitivity of the abdominal wall to filament probing as well as the nocifensive behavior to electrical stimulation of the pancreas. RESULTS: Levels of BDNF in DRGs and spinal cords (T9-13) were significantly higher in trinitrobenzene sulfonic acid rats compared with controls, accompanied by an increase in the number of pancreas-specific neurons expressing BDNF immunoreactivity. Brain-derived neurotrophic factor antagonism suppressed phospho-tropomyosin-related kinase B receptor levels in the spinal cord and significantly reduced behavioral responses in rats with CP. CONCLUSIONS: Brain-derived neurotrophic factor is upregulated in pancreas-specific primary afferent neurons in rats with CP, and BDNF antagonism is associated with a reduction of pain-related behavior in these animals, suggesting an important role for this neurotransmitter in the nociception of CP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperalgesia  ISOBdnf (Rattus norvegicus)8657093; 8657093associated with Pancreatitis and ChronicRGD 
Hyperalgesia  IMP 8657093associated with Pancreatitis and ChronicRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)


Additional Information