GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bdnf | increases expression | EXP | | 401959617 | RGD | Morphine increases expression of Bdnf mRNA in ventral tegmental area | | Bdnf | decreases expression | EXP | | 6480464 | CTD | Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form | PMID:25643298 | Bdnf | multiple interactions | EXP | | 6480464 | CTD | Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter] | PMID:25643298 | Bdnf | decreases expression | ISO | Bdnf (Mus musculus) | 6480464 | CTD | Morphine results in decreased expression of BDNF mRNA | PMID:25643298 | Bdnf | increases expression | ISO | Bdnf (Mus musculus) | 6480464 | CTD | Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein | PMID:19033880 PMID:27461790 | Bdnf | multiple interactions | ISO | Bdnf (Mus musculus) | 6480464 | CTD | AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] | PMID:19033880 PMID:25643298 PMID:27461790 | |
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