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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:134126
Term: picrotoxin
Definition: A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.
Chemical ID: MESH:D010852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfincreases expressionEXP 6480464CTDPicrotoxin results in increased expression of BDNF proteinPMID:11279263
Bdnfdecreases methylationISOBdnf (Mus musculus)6480464CTDPicrotoxin results in decreased methylation of BDNF promoterPMID:18184782
Bdnfincreases expressionISOBdnf (Mus musculus)6480464CTDPicrotoxin results in increased expression of BDNF mRNAPMID:18184782
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