GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bdnf | decreases expression | EXP | | 6480464 | CTD | Lead results in decreased expression of BDNF mRNA; Lead results in decreased expression of BDNF protein | PMID:22345308 | Bdnf | multiple interactions | EXP | | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in decreased cleavage of BDNF protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF mRNA; [Lead results in decreased expression of BDNF protein] which results in decreased phosphorylation of and results in decreased expression of MECP2 protein; BDNF protein inhibits the reaction [Lead results in decreased expression of GRIA2 protein]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased cleavage of BDNF protein]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF mRNA] | PMID:22345308 PMID:23719929 PMID:33978298 | Bdnf | multiple interactions | ISO | Bdnf (Mus musculus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF protein | PMID:32058320 | | ||||||||||||||||||||||
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