RGD Reference Report - Serum neurotrophin profile in systemic sclerosis. - Rat Genome Database

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Serum neurotrophin profile in systemic sclerosis.

Authors: Lise, MC  Sparsa, A  Marie, I  Lalloue, F  Ly, K  Martel, C  Bezanahary, H  Gondran, G  Loustaud-Ratti, V  Bonnetblanc, JM  Vidal, E  Jauberteau, MO  Fauchais, AL 
Citation: Lise MC, etal., PLoS One. 2010 Nov 9;5(11):e13918.
RGD ID: 5144060
Pubmed: PMID:21085492   (View Abstract at PubMed)
PMCID: PMC2976707   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0013918   (Journal Full-text)

BACKGROUND: Neurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data. METHODS: Serum samples were obtained from 55 SSc patients and 32 control subjects to measure NTs levels by ELISA and to determine their relationships with SSc profiles. FINDINGS: Serum NGF levels were higher in SSc patients (288.26 +/- 170.34 pg/mL) than in control subjects (170.34 +/- 50.8 pg/mL, p<0.001) and correlated with gammaglobulins levels and the presence of both anti-cardiolipin and anti-Scl-70 antibodies (p<0.05). In contrast, BDNF levels were lower in SSc patients than in controls (1121.9 +/- 158.1 vs 1372.9 +/- 190.9 pg/mL, p<0.0001), especially in pulmonary arterial hypertension and diffuse SSc as compared to limited forms (all p<0.05). NT-3 levels were similar in SSc and in the control group (2657.2 +/- 2296 vs 2959.3 +/- 2555 pg/mL, NS). BDNF levels correlated negatively with increased NGF levels in the SSc group (and not in controls). CONCLUSION: Low BDNF serum levels were not previously documented in SSc, particularly in the diffuse SSc subset and in patients with pulmonary hypertension or anti-Scl-70 antibodies. The negative correlation between NGF and BDNF levels observed in SSc and not in healthy controls could be implicated in sympathic vascular dysfunction in SSc.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic scleroderma  IEP 5144060protein:decreased expression:serum:RGD 
systemic scleroderma  ISOBDNF (Homo sapiens)5144060; 5144060protein:decreased expression:serum:RGD 
systemic scleroderma  IEP 5144060protein:increased expression:serumRGD 
systemic scleroderma  ISONGF (Homo sapiens)5144060; 5144060protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)
Ngf  (nerve growth factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)
Ngf  (nerve growth factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)
NGF  (nerve growth factor)

Objects referenced in this article
Gene IL15RA interleukin 15 receptor subunit alpha Homo sapiens

Additional Information