RGD Reference Report - [Expression of BDNF and trk B in the cochleas of the aged rats]. - Rat Genome Database

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[Expression of BDNF and trk B in the cochleas of the aged rats].

Authors: Li, Yuru  Liu, Delong  Zhang, Yuanyuan  Wang, Ping  Du, Baodong 
Citation: Li Y, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(19):894-5.
RGD ID: 8655551
Pubmed: PMID:17168119   (View Abstract at PubMed)


OBJECTIVE: To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats.
METHOD: The mRNA expression of BDNF and presbycusis in the cochleas of the aged rats was quantitated by real time PCR.
RESULT: The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. And the difference was statistically significant.
CONCLUSION: The expression of BDNF is closely correlated to presbycusis in the aged rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Presbycusis  ISOBdnf (Rattus norvegicus)8655551; 8655551mRNA:decreased expression:cochleaRGD 
Presbycusis  IEP 8655551mRNA:decreased expression:cochleaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)


Additional Information