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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfmultiple interactionsEXP 6480464CTDProgesterone inhibits the reaction [Estradiol results in increased expression of BDNF protein]PMID:15570173
Bdnfaffects localizationISOBdnf (Mus musculus)6480464CTDProgesterone affects the localization of BDNF proteinPMID:17052708
Bdnfdecreases expressionISOBDNF (Homo sapiens)6480464CTDProgesterone results in decreased expression of BDNF mRNAPMID:18070364
Bdnfincreases expressionISOBdnf (Mus musculus)6480464CTDProgesterone results in increased expression of BDNF mRNA; Progesterone results in increased expression of BDNF proteinPMID:17549730 PMID:23157231
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTDProgesterone inhibits the reaction [VPS54 gene mutant form results in decreased expression of BDNF mRNA]PMID:17052708
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