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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:30145
Term: lithium atom
Definition: An alkali metal atom that has formula Li.
Chemical ID: MESH:D008094
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases expressionEXP 6480464CTDLithium results in decreased expression of BDNF mRNAPMID:21220416
Bdnfincreases expressionEXP 6480464CTDLithium results in increased expression of BDNF mRNA; Lithium results in increased expression of BDNF proteinPMID:17442489 PMID:9073163
Bdnfmultiple interactionsEXP 6480464CTDDiazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Lithium inhibits the reaction [Dextroamphetamine results in decreased expression of BDNF protein]; Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]PMID:16460767 PMID:19954800 PMID:9073163
Bdnfaffects response to substanceISOBDNF (Homo sapiens)6480464CTDBDNF gene polymorphism affects the susceptibility to LithiumPMID:19018715
Bdnfincreases response to substanceISOBDNF (Homo sapiens)6480464CTDBDNF protein results in increased susceptibility to LithiumPMID:19018715
Bdnfmultiple interactionsISOBDNF (Homo sapiens)6480464CTD[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]; [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased secretion of BDNF protein]; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BDNF mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in increased secretion of BDNF proteinPMID:26074776
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