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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfmultiple interactionsEXP 6480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BDNF mRNAPMID:25607892
Bdnfdecreases expressionISOBdnf (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of BDNF mRNA; Diethylhexyl Phthalate results in decreased expression of BDNF proteinPMID:35354077 PMID:37302538
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTDCSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BDNF protein]; MIR93 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BDNF protein]PMID:37302538
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