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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arsine oxides
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Accession:CHEBI:35843 term browser browse the term
Definition:H3As=O and its hydrocarbyl derivatives.


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phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein] CTD PMID:26763395 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases phosphorylation
multiple interactions		 ISO oxophenylarsine results in increased phosphorylation of BCAR1 protein
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]		 CTD PMID:10537051 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases activity ISO oxophenylarsine results in decreased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Casp3 caspase 3 increases activity ISO oxophenylarsine results in increased activity of CASP3 protein CTD PMID:10515888 PMID:19465042 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Cd79a CD79a molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79A protein CTD PMID:8559152 NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935 		JBrowse link
G Cd79b CD79b molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79B protein CTD PMID:8559152 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein] CTD PMID:17141199 PMID:20512473 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]; oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein CTD PMID:9685416 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects localization ISO oxophenylarsine affects the localization of FYN protein CTD PMID:9546377 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO
EXP		 oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]		 CTD PMID:12471042 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein] CTD PMID:9281317 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 oxophenylarsine results in increased expression of HMOX1 mRNA
Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]		 CTD PMID:8612205 PMID:15368090 PMID:19786557 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Id3 inhibitor of DNA binding 3 affects binding ISO oxophenylarsine binds to ID3 protein CTD PMID:23523789 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases localization
multiple interactions		 EXP oxophenylarsine results in decreased localization of IGF1 protein
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:1928324 PMID:9145794 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases localization EXP oxophenylarsine results in decreased localization of IGF2 protein CTD PMID:9145794 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:20512473 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxophenylarsine results in decreased expression of and results in decreased activity of IL1B protein CTD PMID:9266823 PMID:10515888 PMID:10802230 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]		 CTD PMID:17141199 PMID:26763395 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 affects binding
multiple interactions
decreases degradation
decreases activity		 ISO
EXP		 oxophenylarsine binds to INS1 protein
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of 3-O-Methylglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Glucose]
oxophenylarsine results in decreased degradation of INS1 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]		 CTD PMID:1536656 PMID:1629198 PMID:1847587 PMID:2185640 PMID:2202293 More... NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein] CTD PMID:8048502 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions ISO oxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein] CTD PMID:2458350 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases activity ISO oxophenylarsine results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 PMID:19808700 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11880281 PMID:12927602 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11880281 PMID:12927602 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation		 ISO
EXP		 [oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases activity
multiple interactions		 ISO oxophenylarsine results in increased activity of MARK1 protein
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]		 CTD PMID:10737602 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] CTD PMID:10569804 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] CTD PMID:10569804 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects binding ISO oxophenylarsine binds to MTF1 protein CTD PMID:19276070 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity		 ISO [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein] CTD PMID:16183647 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] CTD PMID:12471042 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions		 ISO oxophenylarsine results in increased activity of NFE2L2 protein
oxophenylarsine binds to and results in increased activity of NFE2L2 protein		 CTD PMID:19786557 PMID:19808700 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
multiple interactions		 ISO oxophenylarsine affects the localization of NFKB1 protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of NFKB1 protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of NFKB1 protein]		 CTD PMID:25417048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO oxophenylarsine results in decreased phosphorylation of NFKBIA protein
oxophenylarsine promotes the reaction [Viper Venoms results in decreased phosphorylation of NFKBIA protein]; Viper Venoms promotes the reaction [oxophenylarsine results in decreased phosphorylation of NFKBIA protein]		 CTD PMID:25417048 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos3 nitric oxide synthase 3 affects localization ISO oxophenylarsine affects the localization of NOS3 protein CTD PMID:9546377 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO oxophenylarsine results in increased expression of NQO1 mRNA CTD PMID:19786557 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO oxophenylarsine results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO oxophenylarsine results in increased cleavage of PARP1 protein CTD PMID:10515888 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
decreases phosphorylation
affects localization		 EXP
ISO		 [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]
oxophenylarsine affects the localization of PLCG1 protein		 CTD PMID:1325458 PMID:9281317 PMID:9546377 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein; oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein mutant form CTD PMID:28125064 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pomc proopiomelanocortin decreases activity
multiple interactions		 ISO
EXP		 oxophenylarsine results in decreased activity of POMC protein
oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]
[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone		 CTD PMID:10518784 PMID:12530643 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]		 CTD PMID:9266823 PMID:9576062 PMID:9580637 PMID:18267125 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation		 ISO [oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]
oxophenylarsine results in increased phosphorylation of PTK2 protein		 CTD PMID:10537051 PMID:10569804 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin multiple interactions
increases phosphorylation
affects localization		 ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]
oxophenylarsine affects the localization of PXN protein		 CTD PMID:9546377 PMID:10537051 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RCAN1 protein] CTD PMID:12927602 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions		 ISO oxophenylarsine affects the localization of RELA protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of RELA protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of RELA protein]		 CTD PMID:25417048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions
affects binding		 EXP Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]; carboxyatractyloside inhibits the reaction [oxophenylarsine binds to SLC25A4 protein] CTD PMID:18667415 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO oxophenylarsine results in decreased activity of SLC25A5 protein CTD PMID:16787656 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
affects activity		 ISO oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]; oxophenylarsine inhibits the reaction [Glucose deficiency results in increased activity of SLC2A1 protein]; oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]
oxophenylarsine affects the activity of SLC2A1 protein		 CTD PMID:19686715 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
affects binding		 ISO
EXP		 oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]
oxophenylarsine binds to SLC2A4 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]		 CTD PMID:1536656 PMID:1629198 PMID:8048502 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects localization ISO oxophenylarsine affects the localization of SRC protein CTD PMID:9546377 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO oxophenylarsine results in decreased expression of STAR protein CTD PMID:12530643 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] CTD PMID:11882386 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
affects localization		 ISO Hydrogen Peroxide promotes the reaction [oxophenylarsine affects the localization of STAT3 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]; oxophenylarsine promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]		 CTD PMID:10364193 PMID:11882386 PMID:12093727 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tf transferrin decreases uptake ISO oxophenylarsine results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor affects localization ISO oxophenylarsine affects the localization of TFRC protein CTD PMID:2643384 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity		 ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
oxophenylarsine results in decreased activity of TGFB1 protein		 CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oxophenylarsine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]		 CTD PMID:9576062 PMID:9580637 PMID:10802230 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 multiple interactions
increases expression		 ISO oxophenylarsine promotes the reaction [Viper Venoms results in increased expression of TNFRSF25 protein]; Viper Venoms promotes the reaction [oxophenylarsine results in increased expression of TNFRSF25 protein] CTD PMID:25417048 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions EXP [oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein] CTD PMID:16023995 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
trimethylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP trimethylarsine oxide results in increased expression of ABCB1A mRNA; trimethylarsine oxide results in increased expression of ABCB1A protein CTD PMID:16436460 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP trimethylarsine oxide results in increased expression of ABCC1 mRNA; trimethylarsine oxide results in increased expression of ABCC1 protein CTD PMID:16436460 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP trimethylarsine oxide results in increased expression of ABCC2 mRNA; trimethylarsine oxide results in increased expression of ABCC2 protein CTD PMID:16436460 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP trimethylarsine oxide results in increased expression of ABCC3 mRNA; trimethylarsine oxide results in increased expression of ABCC3 protein CTD PMID:16436460 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO trimethylarsine oxide affects the localization of and results in increased activity of AHR protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in decreased expression of and affects the localization of AHR protein		 CTD PMID:24161444 PMID:26144063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP trimethylarsine oxide results in increased expression of ALDH1A1 mRNA CTD PMID:17481689 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G As3mt arsenite methyltransferase increases chemical synthesis
multiple interactions		 EXP AS3MT protein results in increased chemical synthesis of trimethylarsine oxide
Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]		 CTD PMID:15606138 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Casp3 caspase 3 increases expression EXP trimethylarsine oxide results in increased expression of CASP3 mRNA CTD PMID:17481689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trimethylarsine oxide results in increased expression of CCND1 mRNA CTD PMID:17481689 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP trimethylarsine oxide results in increased expression of CCNE1 mRNA CTD PMID:17481689 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 increases expression EXP trimethylarsine oxide results in increased expression of CDH1 mRNA CTD PMID:17481689 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 increases expression EXP trimethylarsine oxide results in increased expression of CDH2 mRNA CTD PMID:17481689 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression
increases expression
multiple interactions		 EXP
ISO		 trimethylarsine oxide affects the expression of CYP1A1 mRNA
trimethylarsine oxide results in increased expression of CYP1A1 mRNA; trimethylarsine oxide results in increased expression of CYP1A1 protein
trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein		 CTD PMID:17481689 PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP
ISO		 trimethylarsine oxide results in increased expression of CYP1A2 mRNA
trimethylarsine oxide results in increased expression of CYP1A2 mRNA; trimethylarsine oxide results in increased expression of CYP1A2 protein		 CTD PMID:17481689 PMID:26144063 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1B1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1B1 protein
trimethylarsine oxide results in increased expression of CYP1B1 mRNA		 CTD PMID:26042454 PMID:26144063 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 mRNA; [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 protein
trimethylarsine oxide results in increased expression of CYP2B1 mRNA		 CTD PMID:12115560 PMID:17481689 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:12115560 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP trimethylarsine oxide results in increased expression of CYP2C11 mRNA CTD PMID:17481689 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression EXP trimethylarsine oxide results in decreased expression of DNMT1 mRNA CTD PMID:17481689 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Faslg Fas ligand increases expression EXP trimethylarsine oxide results in increased expression of FASLG mRNA CTD PMID:17481689 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression EXP trimethylarsine oxide results in increased expression of GJB1 mRNA CTD PMID:17481689 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression
increases expression		 EXP trimethylarsine oxide results in decreased expression of GSTA2 mRNA; trimethylarsine oxide results in decreased expression of GSTA2 protein
trimethylarsine oxide results in increased expression of GSTA2 mRNA		 CTD PMID:16436460 PMID:17481689 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTM1 mRNA; trimethylarsine oxide results in increased expression of GSTM1 protein CTD PMID:16436460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTP1 mRNA CTD PMID:17481689 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO trimethylarsine oxide results in increased expression of HMOX1 mRNA; trimethylarsine oxide results in increased expression of HMOX1 protein CTD PMID:26144063 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression EXP trimethylarsine oxide results in increased expression of ITIH3 mRNA CTD PMID:17481689 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924 		JBrowse link
G Krt18 keratin 18 decreases expression EXP trimethylarsine oxide results in decreased expression of KRT18 mRNA CTD PMID:17481689 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP trimethylarsine oxide results in increased expression of MAPK14 mRNA CTD PMID:17481689 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP trimethylarsine oxide results in decreased expression of MAPK8 mRNA CTD PMID:17481689 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:24161444 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of NQO1 protein
trimethylarsine oxide results in increased expression of NQO1 mRNA; trimethylarsine oxide results in increased expression of NQO1 protein		 CTD PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP trimethylarsine oxide results in increased expression of OGG1 mRNA CTD PMID:17481689 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP trimethylarsine oxide results in increased expression of PCNA mRNA CTD PMID:17481689 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Prkca protein kinase C, alpha increases expression EXP trimethylarsine oxide results in increased expression of PRKCA mRNA CTD PMID:17481689 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP trimethylarsine oxide results in increased expression of PRKCG mRNA CTD PMID:17481689 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO trimethylarsine oxide results in decreased secretion of TNF protein CTD PMID:9548797 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      atom 19836
        metalloid atom 14322
          arsenic atom 13266
            arsenic molecular entity 13266
              arsine oxides 106
                arsine oxide + 0
                phenylarsine oxide 75
                trimethylarsine oxide 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      p-block molecular entity 19786
                        pnictogen molecular entity 19047
                          arsenic molecular entity 13266
                            arsine oxides 106
                              arsine oxide + 0
                              phenylarsine oxide 75
                              trimethylarsine oxide 36
paths to the root