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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein] |
CTD |
PMID:35547012 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:27087047 PMID:27345130 PMID:32383521 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein |
CTD |
PMID:33754447 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases response to substance |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] |
CTD |
PMID:22186599 PMID:32383521 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arap2 |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] |
CTD |
PMID:27087047 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] |
CTD |
PMID:27087047 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein] [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA] |
CTD |
PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; coenzyme Q10 inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein] |
CTD |
PMID:35547012 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
EXP ISO |
coenzyme Q10 results in increased expression of BCL2 mRNA [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA] [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein] |
CTD |
PMID:18817789 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:27087047 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
coenzyme Q10 results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C4b |
complement C4B |
decreases expression |
ISO |
coenzyme Q10 results in decreased expression of C4B mRNA |
CTD |
PMID:19555370 |
|
NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein] [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] |
CTD |
PMID:20510337 PMID:22186599 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417 PMID:34939713 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] |
CTD |
PMID:27087047 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] |
CTD |
PMID:27087047 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA] [coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA] |
CTD |
PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 PMID:32116774 PMID:33271250 PMID:33754447 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] |
CTD |
PMID:27087047 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
coenzyme Q10 results in increased expression of CCND1 protein |
CTD |
PMID:34668565 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] |
CTD |
PMID:27087047 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein] |
CTD |
PMID:34668565 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA] |
CTD |
PMID:34186417 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSD protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSD mRNA] |
CTD |
PMID:34186417 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctss |
cathepsin S |
decreases expression |
ISO |
coenzyme Q10 results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA] |
CTD |
PMID:33856607 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] |
CTD |
PMID:23640862 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Eps15 |
epidermal growth factor receptor pathway substrate 15 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
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G |
Etv3 |
ETS variant transcription factor 3 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314
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G |
Fadd |
Fas associated via death domain |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] |
CTD |
PMID:27087047 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Faslg |
Fas ligand |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] |
CTD |
PMID:27087047 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fshr |
follicle stimulating hormone receptor |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] |
CTD |
PMID:31557371 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein] |
CTD |
PMID:33548410 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression multiple interactions |
ISO EXP |
coenzyme Q10 results in decreased expression of GFAP mRNA [Oxygen co-treated with coenzyme Q10] results in decreased expression of GFAP protein |
CTD |
PMID:19555370 PMID:35212449 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein] |
CTD |
PMID:27387968 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein] |
CTD |
PMID:27387968 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein] Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:27174133 PMID:27387968 PMID:33271250 PMID:33393703 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO EXP |
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA] coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA] |
CTD |
PMID:32116774 PMID:33271250 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP ISO |
coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein] coenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:22186599 PMID:34668565 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions increases expression |
EXP |
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA] coenzyme Q10 results in increased expression of GSR mRNA |
CTD |
PMID:19958828 PMID:32116774 PMID:33393703 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:27174133 PMID:32116774 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
ISO EXP |
[Valproic Acid co-treated with coenzyme Q10] inhibits the reaction [Benzene results in increased expression of IL10 protein] coenzyme Q10 results in increased expression of IL10 mRNA; coenzyme Q10 results in increased expression of IL10 protein coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein] |
CTD |
PMID:32116774 PMID:35090963 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein] |
CTD |
PMID:32116774 PMID:32383521 PMID:34939713 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] |
CTD |
PMID:32383521 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] |
CTD |
PMID:32383521 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Kcnj6 |
potassium inwardly-rectifying channel, subfamily J, member 6 |
decreases abundance |
ISO |
KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 |
CTD |
PMID:15256069 |
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NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
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G |
Lamp2 |
lysosomal-associated membrane protein 2 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of LAMP2 protein] |
CTD |
PMID:34186417 |
|
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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G |
Ldhc |
lactate dehydrogenase C |
multiple interactions increases activity |
EXP |
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein] coenzyme Q10 results in increased activity of LDHC protein |
CTD |
PMID:33548410 |
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NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] |
CTD |
PMID:27087047 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] |
CTD |
PMID:27087047 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] |
CTD |
PMID:26519479 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mt3 |
metallothionein 3 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein] |
CTD |
PMID:33856607 |
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NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] |
CTD |
PMID:21370964 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
increases expression multiple interactions |
ISO |
coenzyme Q10 results in increased expression of NDUFB6 protein coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA] |
CTD |
PMID:19523936 |
|
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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G |
Ndufs7 |
NADH:ubiquinone oxidoreductase core subunit S7 |
increases expression |
ISO |
coenzyme Q10 results in increased expression of NDUFS7 protein |
CTD |
PMID:19523936 |
|
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein] |
CTD |
PMID:34939713 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein] |
CTD |
PMID:33754447 |
|
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
EXP ISO |
coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA] coenzyme Q10 results in increased expression of NFE2L2 mRNA coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:27174133 PMID:32116774 PMID:33271250 PMID:34939713 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA] |
CTD |
PMID:20510337 PMID:32116774 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] |
CTD |
PMID:23640862 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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|
G |
Oscar |
osteoclast associated Ig-like receptor |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein] |
CTD |
PMID:33754447 |
|
NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
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|
G |
Pah |
phenylalanine hydroxylase |
decreases expression |
ISO |
coenzyme Q10 results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
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|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
ISO |
coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA] coenzyme Q10 results in increased expression of PCNA protein |
CTD |
PMID:31557371 PMID:34668565 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] |
CTD |
PMID:22186599 |
|
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein] |
CTD |
PMID:33271250 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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|
G |
Pou2f1 |
POU class 2 homeobox 1 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
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G |
Ppp2r5c |
protein phosphatase 2, regulatory subunit B', gamma |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein] |
CTD |
PMID:33271250 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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|
G |
Psd3 |
pleckstrin and Sec7 domain containing 3 |
multiple interactions |
ISO |
coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] |
CTD |
PMID:21370964 |
|
NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein] |
CTD |
PMID:34939713 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Sarm1 |
sterile alpha and TIR motif containing 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA] |
CTD |
PMID:34939713 |
|
NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822
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G |
Skap2 |
src kinase associated phosphoprotein 2 |
decreases expression |
ISO |
coenzyme Q10 results in decreased expression of SKAP2 mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] |
CTD |
PMID:27174133 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO EXP |
coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein] coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]] [coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein |
CTD |
PMID:15114628 PMID:19476553 PMID:21843543 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Sod2 |
superoxide dismutase 2 |
affects expression increases expression multiple interactions |
EXP ISO |
coenzyme Q10 affects the expression of SOD2 protein coenzyme Q10 results in increased expression of SOD2 mRNA coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA] coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA] coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein] |
CTD |
PMID:22083459 PMID:24008411 PMID:32116774 PMID:33271250 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] |
CTD |
PMID:33271250 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] |
CTD |
PMID:27087047 PMID:27174133 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein] [Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein] [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein] |
CTD |
PMID:20510337 PMID:26519479 PMID:32116774 PMID:32383521 PMID:34939713 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] |
CTD |
PMID:33754447 |
|
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO EXP |
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein] |
CTD |
PMID:20510337 PMID:33393703 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Traf2 |
Tnf receptor-associated factor 2 |
multiple interactions |
ISO |
[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein] |
CTD |
PMID:33754447 |
|
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
embelin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:24694877 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atg12 |
autophagy related 12 |
multiple interactions |
ISO |
embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] |
CTD |
PMID:28722333 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
ISO |
embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] |
CTD |
PMID:28722333 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
embelin results in increased expression of BAX protein |
CTD |
PMID:24694877 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
embelin results in decreased expression of BCL2 protein |
CTD |
PMID:24694877 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
increases expression |
ISO |
embelin results in increased expression of BECN1 protein |
CTD |
PMID:28722333 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases degradation |
ISO |
embelin results in increased cleavage of CASP3 protein 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein] |
CTD |
PMID:24694877 PMID:28722333 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases degradation multiple interactions |
ISO |
embelin results in increased degradation of CASP9 protein 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein] |
CTD |
PMID:28722333 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein] |
CTD |
PMID:32020686 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
embelin results in decreased expression of CCND1 protein |
CTD |
PMID:24694877 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
embelin results in increased expression of CDH1 protein |
CTD |
PMID:24694877 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
embelin results in decreased expression of CDK2 protein |
CTD |
PMID:24694877 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
embelin results in decreased expression of CDK6 protein |
CTD |
PMID:24694877 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Dffa |
DNA fragmentation factor subunit alpha |
increases cleavage |
ISO |
embelin results in increased cleavage of DFFA protein |
CTD |
PMID:28722333 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
embelin results in decreased expression of GLI1 protein |
CTD |
PMID:24694877 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
decreases expression |
ISO |
embelin results in decreased expression of GLI2 protein |
CTD |
PMID:24694877 |
|
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein] |
CTD |
PMID:32020686 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein] |
CTD |
PMID:32020686 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Kdr |
kinase insert domain receptor |
decreases expression |
ISO |
embelin results in decreased expression of KDR protein |
CTD |
PMID:24694877 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
embelin results in decreased expression of MKI67 protein |
CTD |
PMID:24694877 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
embelin results in decreased expression of MMP2 protein |
CTD |
PMID:24694877 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
embelin results in decreased expression of MMP9 protein |
CTD |
PMID:24694877 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
embelin results in increased cleavage of PARP1 protein 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein] |
CTD |
PMID:24694877 PMID:28722333 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
embelin results in decreased expression of PCNA protein |
CTD |
PMID:24694877 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
embelin results in decreased expression of PTGS2 protein |
CTD |
PMID:24694877 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein] |
CTD |
PMID:32020686 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
embelin results in decreased expression of SNAI1 protein |
CTD |
PMID:24694877 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
embelin results in decreased expression of SNAI2 protein |
CTD |
PMID:24694877 |
|
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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G |
Sqstm1 |
sequestosome 1 |
increases degradation |
ISO |
embelin results in increased degradation of SQSTM1 protein |
CTD |
PMID:28722333 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
embelin inhibits the reaction [Paraquat results in increased expression of TNF protein] |
CTD |
PMID:32020686 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
embelin results in increased expression of TNFRSF10A protein |
CTD |
PMID:24694877 |
|
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
embelin results in decreased expression of VEGFA protein |
CTD |
PMID:24694877 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases activity increases degradation |
ISO |
embelin results in decreased activity of XIAP protein embelin results in increased degradation of XIAP protein |
CTD |
PMID:16339139 PMID:28722333 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Zeb1 |
zinc finger E-box binding homeobox 1 |
decreases expression |
ISO |
embelin results in decreased expression of ZEB1 protein |
CTD |
PMID:24694877 |
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NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
ilimaquinone results in decreased expression of BCL2 protein |
CTD |
PMID:24930757 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
ilimaquinone results in decreased expression of BCL2L1 protein |
CTD |
PMID:24930757 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
ISO |
[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein] ilimaquinone results in increased cleavage of CASP3 protein |
CTD |
PMID:24930757 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
ilimaquinone results in increased cleavage of CASP8 protein |
CTD |
PMID:24930757 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA] |
CTD |
PMID:24930757 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
ilimaquinone results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:24930757 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
ilimaquinone results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:24930757 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] ilimaquinone results in increased cleavage of PARP1 protein |
CTD |
PMID:24930757 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pld2 |
phospholipase D2 |
multiple interactions increases activity |
ISO |
1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] |
CTD |
PMID:17897952 |
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NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA] ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein |
CTD |
PMID:24930757 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:24930757 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of ALDH1 protein |
CTD |
PMID:36847822 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Casp1 |
caspase 1 |
decreases expression multiple interactions |
ISO |
ubiquinone-O results in decreased expression of CASP1 protein ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein] |
CTD |
PMID:36847822 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Cd24 |
CD24 molecule |
increases expression |
ISO |
ubiquinone-O results in increased expression of CD24 protein |
CTD |
PMID:36847822 |
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NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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G |
Cd44 |
CD44 molecule |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of CD44 protein |
CTD |
PMID:36847822 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
ubiquinone-O results in increased expression of CDH1 mRNA; ubiquinone-O results in increased expression of CDH1 protein |
CTD |
PMID:36847822 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of CDH2 mRNA; ubiquinone-O results in decreased expression of CDH2 protein |
CTD |
PMID:36847822 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of HIF1A protein |
CTD |
PMID:36847822 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk2 |
hexokinase 2 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of HK2 protein |
CTD |
PMID:36847822 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Il18 |
interleukin 18 |
decreases expression multiple interactions |
ISO |
ubiquinone-O results in decreased expression of IL18 protein ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein] |
CTD |
PMID:36847822 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
decreases expression multiple interactions |
ISO |
ubiquinone-O results in decreased expression of IL1B protein ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA] |
CTD |
PMID:36847822 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of LDHA protein |
CTD |
PMID:36847822 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA] |
CTD |
PMID:36847822 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA] |
CTD |
PMID:36847822 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
decreases expression multiple interactions |
ISO |
ubiquinone-O results in decreased expression of NLRP3 protein ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein] |
CTD |
PMID:36847822 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO |
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein] ubiquinone-O results in decreased expression of NOS2 protein |
CTD |
PMID:36847822 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of PDK1 protein |
CTD |
PMID:36847822 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pkm |
pyruvate kinase M1/2 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of PKM protein |
CTD |
PMID:36847822 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pycard |
PYD and CARD domain containing |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of PYCARD protein |
CTD |
PMID:36847822 |
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NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of SLC2A1 mRNA; ubiquinone-O results in decreased expression of SLC2A1 protein |
CTD |
PMID:36847822 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Tlr4 |
toll-like receptor 4 |
decreases expression |
ISO |
ubiquinone-O results in decreased expression of TLR4 protein |
CTD |
PMID:36847822 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
multiple interactions |
ISO |
[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1 |
CTD |
PMID:20399199 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Kcnj6 |
potassium inwardly-rectifying channel, subfamily J, member 6 |
decreases abundance |
ISO |
KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9 |
CTD |
PMID:15256069 |
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NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] |
CTD |
PMID:20584200 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions |
ISO |
ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver |
RGD |
PMID:29156373 |
RGD:15036805 |
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA] Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein] |
CTD |
PMID:12880480 PMID:24732427 PMID:35866224 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
increases activity |
EXP |
Ubiquinone results in increased activity of CAT protein |
CTD |
PMID:20034476 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Coq8a |
coenzyme Q8A |
increases chemical synthesis |
ISO |
COQ8A protein results in increased chemical synthesis of Ubiquinone |
CTD |
PMID:18319072 |
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NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
multiple interactions increases metabolic processing |
ISO EXP |
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] DHODH protein results in increased metabolism of Ubiquinone 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] |
CTD |
PMID:9802339 PMID:11248707 |
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NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of GPT protein] |
CTD |
PMID:35866224 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] |
CTD |
PMID:17516992 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] |
CTD |
PMID:17516992 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3] |
CTD |
PMID:20020783 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein |
CTD |
PMID:18377693 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone] |
CTD |
PMID:10731415 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein] |
CTD |
PMID:17516992 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
decreases reduction decreases oxidation |
ISO |
XRCC1 gene mutant form results in decreased reduction of Ubiquinone XRCC1 results in decreased oxidation of Ubiquinone |
CTD |
PMID:30998386 |
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NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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