Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Description: ENCODES a protein that exhibits protein complex binding; actin binding (ortholog); beta-catenin binding (ortholog); INVOLVED IN cellular response to manganese ion; mitochondrion localization; mitophagy; PARTICIPATES IN altered mitochondrial autophagy pathway; altered ubiquitin/proteasome degradation pathway; mitochondrial autophagy pathway; ASSOCIATED WITH Adenocarcinoma of Lung (ortholog); Alzheimer Disease (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm; cytoplasmic vesicle; cytosol; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; androgen antagonist
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase parkin; Park; Park2; parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase
Orthologs:
Homo sapiens (human) : PRKN (parkin RBR E3 ubiquitin protein ligase)  HGNC
Mus musculus (house mouse) : Park2 (Parkinson disease (autosomal recessive, juvenile) 2, parkin)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
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Allele / Splice: Park2em1Sage  
Genetic Models: LE-Park2em1Sage-/- LE-Park2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBI
Cytogenetic Map1q11NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prkn
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 61797
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2017-05-09
Status: ACTIVE