Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Description: ENCODES a protein that exhibits protein complex binding; protein kinase binding; actin binding (ortholog); INVOLVED IN autophagy of mitochondrion; brain development; cellular response to hydrogen sulfide; PARTICIPATES IN altered mitochondrial autophagy pathway; altered ubiquitin/proteasome degradation pathway; mitochondrial autophagy pathway; ASSOCIATED WITH Diabetes Mellitus, Type 2; Liver Cirrhosis, Experimental; Parkinson Disease; FOUND IN axon; cytoplasm; cytoplasmic vesicle; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; androgen antagonist
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase parkin; Park; Park2; parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase
Orthologs:
Homo sapiens (human) : PRKN (parkin RBR E3 ubiquitin protein ligase)  HGNC  AGR
Mus musculus (house mouse) : Park2 (Parkinson disease (autosomal recessive, juvenile) 2, parkin)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
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Allele / Splice: Prkn em1Sage  
Genetic Models: LE-Prkn em1Sage-/- LE-Prkn em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBI
Cytogenetic Map1q11NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prkn
AGR Gene
NCBI Gene
Ensembl Gene
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RGD Object Information
RGD ID: 61797
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE