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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estriol
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Accession:CHEBI:27974 term browser browse the term
Definition:A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
Synonyms:exact_synonym: estra-1,3,5(10)-triene-3,16alpha,17beta-triol
 related_synonym: (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol;   1,3,5(10)-Estratriene-3,16-alpha,17beta-triol;   16alpha,17beta-estriol;   16alpha-hydroxyestradiol;   3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene;   Estriel;   Formula=C18H24O3;   InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1;   InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)[C@H](O)C[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21;   oestriol;   trihydroxyestrin
 alt_id: CHEBI:23969;   CHEBI:42467;   CHEBI:4869
 xref: Beilstein:2508172;   CAS:50-27-1;   DrugBank:DB04573;   Drug_Central:3187;   HMDB:HMDB0000153;   KEGG:C05141;   KEGG:D00185;   LINCS:LSM-2368;   LIPID_MAPS_instance:LMST02010003
 xref_mesh: MESH:D004964
 xref: MetaCyc:ESTRIOL;   PDBeChem:ESL;   PMID:11133265;   PMID:23777262;   PMID:9373313;   Reaxys:2508172;   VSDB:1907;   Wikipedia:Estriol


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estriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export
multiple interactions
increases expression		 ISO ABCB1 protein results in increased export of Estriol
Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estriol]
Estriol results in increased expression of ABCB1 mRNA; Estriol results in increased expression of ABCB1 protein		 CTD PMID:15290871 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]
Estriol results in increased expression of ABCG2 mRNA; Estriol results in increased expression of ABCG2 protein		 CTD PMID:16849015 PMID:17823853 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acrbp acrosin binding protein decreases expression ISO Estriol results in decreased expression of ACRBP mRNA CTD PMID:25575267 NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO Estriol affects the expression of ACTC1 mRNA CTD PMID:23184660 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Afp alpha-fetoprotein increases expression
affects binding		 ISO
EXP		 Estriol results in increased expression of AFP protein
Estriol binds to AFP protein		 CTD PMID:2470397 PMID:18497072 PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Estriol results in increased expression of AGER protein CTD PMID:15878629 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Estriol results in decreased expression of AGTR1 mRNA CTD PMID:15159206 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akap17a A-kinase anchoring protein 17A decreases expression ISO Estriol results in decreased expression of AKAP17B mRNA CTD PMID:25575267 NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479 		JBrowse link
G Akirin1 akirin 1 increases expression ISO Estriol results in increased expression of AKIRIN1 mRNA CTD PMID:25575267 NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762 		JBrowse link
G Alb albumin decreases expression ISO Estriol results in decreased expression of ALB protein CTD PMID:2470397 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Amer1 APC membrane recruitment protein 1 decreases expression ISO Estriol results in decreased expression of AMER1 mRNA CTD PMID:25575267 NCBI chr  X:60,300,595...60,316,480
Ensembl chr  X:60,295,751...60,316,440 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 Estriol binds to AR protein
Estriol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]		 CTD PMID:14565775 PMID:18324785 PMID:28803809 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Estriol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Estriol results in increased expression of AURKB mRNA CTD PMID:25575267 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 decreases expression ISO Estriol results in decreased expression of B3GNTL1 mRNA CTD PMID:25575267 NCBI chr10:106,870,237...106,933,723
Ensembl chr10:106,873,169...106,933,637 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO Estriol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO Estriol results in decreased expression of BMF mRNA CTD PMID:25575267 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Btbd10 BTB domain containing 10 increases expression ISO Estriol results in increased expression of BTBD10 mRNA CTD PMID:25575267 NCBI chr 1:167,431,311...167,489,320
Ensembl chr 1:167,431,329...167,489,916 		JBrowse link
G C2cd2l C2CD2-like increases expression ISO Estriol results in increased expression of C2CD2L mRNA CTD PMID:25575267 NCBI chr 8:44,648,074...44,658,856
Ensembl chr 8:44,648,079...44,658,340 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Estriol results in increased expression of CCN1 mRNA CTD PMID:25575267 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Estriol results in increased expression of CCNB1 mRNA CTD PMID:25575267 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Estriol results in increased expression of CCNB2 mRNA CTD PMID:25575267 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Estriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein] CTD PMID:23624423 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Estriol results in increased expression of CD274 protein CTD PMID:21317386 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd276 Cd276 molecule increases expression ISO Estriol results in increased expression of CD276 protein CTD PMID:21317386 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Estriol results in increased expression of CD80 protein CTD PMID:21317386 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule increases expression ISO Estriol results in increased expression of CD86 protein CTD PMID:21317386 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cd99l2 CD99 molecule-like 2 decreases expression ISO Estriol results in decreased expression of CD99L2 mRNA CTD PMID:25575267
G Cdc42se1 CDC42 small effector 1 increases expression ISO Estriol results in increased expression of CDC42SE1 mRNA CTD PMID:25575267 NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Estriol results in increased expression of CDKN1A mRNA CTD PMID:25575267 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chst8 carbohydrate sulfotransferase 8 increases expression ISO Estriol results in increased expression of CHST8 mRNA CTD PMID:25575267 NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900 		JBrowse link
G Ckb creatine kinase B increases expression EXP Estriol results in increased expression of CKB CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 decreases expression ISO Estriol results in decreased expression of CNRIP1 mRNA CTD PMID:25575267 NCBI chr14:91,462,877...91,492,739
Ensembl chr14:91,462,647...91,492,735 		JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression ISO Estriol results in increased expression of CRISPLD2 mRNA CTD PMID:25575267 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO Estriol inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]
Estriol results in decreased expression of CYP19A1 mRNA		 CTD PMID:21296134 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:12093619 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Estriol results in increased expression of CYP2B10 mRNA CTD PMID:7771797 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Dennd2a DENN domain containing 2A increases expression ISO Estriol results in increased expression of DENND2A mRNA CTD PMID:25575267 NCBI chr 4:68,233,016...68,332,235
Ensembl chr 4:68,233,958...68,332,105 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression ISO Estriol results in decreased expression of DTX4 mRNA CTD PMID:25575267 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Eeig1 estrogen-induced osteoclastogenesis regulator 1 increases expression ISO Estriol results in increased expression of EEIG1 mRNA CTD PMID:14605097 NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Estriol results in increased expression of EGR1 mRNA CTD PMID:1717835 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr3 early growth response 3 increases expression ISO Estriol results in increased expression of EGR3 mRNA CTD PMID:15159206 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Estriol results in increased expression of EIF2S2 mRNA CTD PMID:25575267 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eno2 enolase 2 decreases expression ISO Estriol results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
affects localization
affects binding
increases activity		 ISO
EXP		 Estriol binds to and results in increased activity of ESR1 protein; Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estriol inhibits the reaction [Estradiol binds to ESR1 protein]; Estriol promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]
Estriol results in increased expression of ESR1 mRNA
Estriol affects the localization of ESR1 protein
Estriol binds to ESR1 protein		 CTD PMID:9048584 PMID:11162928 PMID:11518614 PMID:12127041 PMID:12598185 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO
EXP		 Estriol binds to and results in increased activity of ESR2 protein; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol binds to ESR2 protein
Estriol binds to Esr2 protein		 CTD
RGD		 PMID:8650195 PMID:9048584 PMID:9492041 PMID:9751507 PMID:11518614 More... RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression ISO Estriol results in increased expression of ETF1 mRNA CTD PMID:25575267 NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810 		JBrowse link
G F10 coagulation factor X increases expression ISO Estriol results in increased expression of F10 protein CTD PMID:614942 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Estriol results in increased expression of FOS mRNA CTD PMID:2118345 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxa2 forkhead box A2 increases expression ISO Estriol results in increased expression of FOXA2 mRNA CTD PMID:23184660 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Gh1 growth hormone 1 increases expression EXP Estriol results in increased expression of GH1 mRNA CTD PMID:15240998 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Estriol results in decreased expression of HNF4A mRNA CTD PMID:23184660 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hoxa10 homeobox A10 decreases expression ISO Estriol results in decreased expression of HOXA10 mRNA CTD PMID:16402032 NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919 		JBrowse link
G Hoxa11 homeobox A11 decreases expression ISO Estriol results in decreased expression of HOXA11 mRNA CTD PMID:16402032 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 ISO Estriol results in decreased expression of IFNG protein
Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]		 CTD PMID:11063824 PMID:21317386 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Estriol results in increased expression of IGF1 mRNA CTD PMID:15969240 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Estriol results in decreased expression of IGFBP5 mRNA CTD PMID:15159206 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Il10 interleukin 10 increases expression ISO Estriol results in increased expression of IL10 mRNA CTD PMID:21317386 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A increases expression ISO Estriol results in increased expression of IL12A mRNA CTD PMID:21317386 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B decreases expression ISO Estriol results in decreased expression of IL12B mRNA CTD PMID:21317386 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Estriol results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Estriol results in decreased expression of IL23A mRNA CTD PMID:21317386 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il4 interleukin 4 increases expression ISO Estriol results in increased expression of IL4 protein CTD PMID:21317386 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO Estriol results in decreased expression of IL6 mRNA
Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tamoxifen inhibits the reaction [Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]		 CTD PMID:8979148 PMID:10731640 PMID:21317386 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO Estriol results in increased expression of INHBB mRNA CTD PMID:25575267 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 decreases expression ISO Estriol results in decreased expression of IP6K2 mRNA CTD PMID:25575267 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Estriol results in increased expression of JUN mRNA CTD PMID:2118345 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Estriol results in decreased expression of LPAR4 mRNA CTD PMID:25575267 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977 		JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Estriol results in decreased expression of LSM10 mRNA CTD PMID:25575267 NCBI chr 5:138,365,983...138,375,856
Ensembl chr 5:138,373,119...138,377,505 		JBrowse link
G Mak16 MAK16 homolog increases expression ISO Estriol results in increased expression of RBM13 mRNA CTD PMID:25575267 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO
EXP		 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO
EXP		 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Estriol results in increased expression of MYC mRNA CTD PMID:2118345 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression
multiple interactions		 ISO Estriol results in increased expression of NAMPT mRNA
[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]		 CTD PMID:20004694 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Estriol results in decreased expression of NOS2 mRNA		 CTD PMID:11063824 PMID:21317386 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Estriol results in increased expression of NOS3 mRNA; Estriol results in increased expression of NOS3 protein CTD PMID:12547825 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppc natriuretic peptide C increases expression ISO Estriol results in increased expression of NPPC protein CTD PMID:9435603 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Estriol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nup50 nucleoporin 50 increases expression ISO Estriol results in increased expression of NUP50 mRNA CTD PMID:25575267 NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 increases expression ISO Estriol results in increased expression of PDCD1LG2 protein CTD PMID:21317386 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938 		JBrowse link
G Pde12 phosphodiesterase 12 increases expression ISO Estriol results in increased expression of PDE12 mRNA CTD PMID:25575267 NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Estriol results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Estriol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:15159206 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Pgr progesterone receptor increases expression ISO Estriol results in increased expression of PGR mRNA CTD PMID:19820872 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 decreases expression ISO Estriol results in decreased expression of PIK3IP1 mRNA CTD PMID:25575267 NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit decreases expression ISO Estriol results in decreased expression of POLG2 mRNA CTD PMID:25575267 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B increases expression ISO Estriol results in increased expression of PPP1R15B mRNA CTD PMID:25575267 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737 		JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Estriol results in increased expression of PPP4R1 mRNA CTD PMID:25575267 NCBI chr 9:105,391,271...105,450,626
Ensembl chr 9:105,391,412...105,450,633 		JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression		 EXP
ISO		 Estriol promotes the reaction [Estradiol results in increased expression of PRL mRNA]
4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; bisphenol A affects the reaction [Estriol results in increased secretion of PRL protein]
Estriol results in increased expression of PRL mRNA; Estriol results in increased expression of PRL protein		 CTD PMID:3780563 PMID:3996322 PMID:7306549 PMID:20950447 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prrx2 paired related homeobox 2 increases expression ISO Estriol results in increased expression of PRRX2 mRNA CTD PMID:25575267 NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Estriol inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:12547825 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rrp1b ribosomal RNA processing 1B increases expression ISO Estriol results in increased expression of RRP1B mRNA CTD PMID:25575267 NCBI chr20:10,123,111...10,148,704
Ensembl chr20:10,123,125...10,147,928 		JBrowse link
G Sdc3 syndecan 3 increases expression EXP Estriol results in increased expression of SDC3 mRNA CTD PMID:11024013 NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Estriol results in decreased expression of SELENBP1 mRNA CTD PMID:15159206 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Estriol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO Estriol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO Estriol results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Estriol results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a6 solute carrier family 7 member 6 increases expression ISO Estriol results in increased expression of SLC7A6 mRNA CTD PMID:25575267 NCBI chr19:34,073,472...34,100,268
Ensembl chr19:34,074,286...34,100,268 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Estriol results in increased expression of SOCS3 mRNA CTD PMID:25575267 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Estriol results in increased expression of STAT5A mRNA CTD PMID:25575267 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Estriol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Synpo synaptopodin increases expression ISO Estriol results in increased expression of SYNPO mRNA CTD PMID:25575267 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126 		JBrowse link
G Tbx19 T-box transcription factor 19 decreases abundance ISO TBX19 gene mutant form results in decreased abundance of Estriol CTD PMID:16390921 NCBI chr13:77,450,848...77,484,475
Ensembl chr13:77,450,849...77,504,163 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO Estriol results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estriol results in increased expression of TFF1 mRNA]		 CTD PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Estriol results in increased expression of TGFB1 mRNA CTD PMID:21317386 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO Estriol results in decreased expression of THRA mRNA CTD PMID:25575267 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tmem183a transmembrane protein 183A increases expression ISO Estriol results in increased expression of TMEM183A mRNA CTD PMID:25575267 NCBI chr13:45,803,641...45,820,409
Ensembl chr13:45,803,639...45,820,375 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Estriol inhibits the reaction [TNF protein affects the localization of RELA protein]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
Estriol affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tamoxifen inhibits the reaction [Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver and protein in serum]		 CTD
RGD		 PMID:8979148 PMID:11063824 PMID:12547825 PMID:9575848 RGD:15017096 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO Estriol results in decreased expression of TXNIP mRNA CTD PMID:25575267 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Tyr tyrosinase multiple interactions ISO Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) increases expression ISO Estriol results in increased expression of UBE2F mRNA CTD PMID:25575267 NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Estriol; UGT1A1 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Estriol; UGT1A3 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Estriol; UGT1A8 protein results in increased glucuronidation of Estriol CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of Estriol; UGT2B7 protein results in increased glucuronidation of Estriol CTD PMID:8423545 PMID:8517101 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Utp6 UTP6 small subunit processome component increases expression ISO Estriol results in increased expression of UTP6 mRNA CTD PMID:25575267 NCBI chr10:64,897,321...64,927,997
Ensembl chr10:64,897,328...64,927,997 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:12547825 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases expression ISO Estriol results in increased expression of VDR mRNA CTD PMID:14992164 PMID:15775415 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Estriol results in increased expression of VEGFA mRNA alternative form CTD PMID:8344219 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Estriol results in increased expression of VTCN1 protein CTD PMID:21317386 NCBI chr 2:188,253,594...188,321,658
Ensembl chr 2:188,253,594...188,321,658 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Estriol results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Zfp688 zinc finger protein 688 decreases expression ISO Estriol results in decreased expression of ZFP688 mRNA CTD PMID:25575267 NCBI chr 1:182,039,366...182,043,035
Ensembl chr 1:182,039,931...182,043,103 		JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions
increases hydrolysis		 ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        molecular messenger 18611
          hormone 18455
            sex hormone 18274
              estrogen 18229
                estriol 124
                  3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                  6-ketoestriol 0
                  estriol 16-O-(beta-D-glucuronide) 1
                  estriol 3-O-(beta-D-glucuronide) 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic polycyclic compound 17225
                                  steroid 14678
                                    hydroxy steroid 14425
                                      16-hydroxy steroid 157
                                        16alpha-hydroxy steroid 153
                                          estriol 124
                                            3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                                            6-ketoestriol 0
                                            estriol 16-O-(beta-D-glucuronide) 1
                                            estriol 3-O-(beta-D-glucuronide) 1
paths to the root