Gene: Sirt3 (sirtuin 3) Rattus norvegicus
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Symbol: Sirt3
Name: sirtuin 3
Description: ENCODES a protein that exhibits enzyme binding; zinc ion binding (ortholog); INVOLVED IN aging; negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH congestive heart failure; Heart Failure; Myocardial Infarction; FOUND IN mitochondrion; cytoplasm (ortholog); membrane (ortholog); INTERACTS WITH (R)-lipoic acid; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC293615; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIRT3L mitochondrial; sirtuin; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT3 (sirtuin 3)  HGNC  AGR
Mus musculus (house mouse) : Sirt3 (sirtuin 3)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Sirt3 (sirtuin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT3 (sirtuin 3)
Canis lupus familiaris (dog) : SIRT3 (sirtuin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt3 (sirtuin 3)
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Allele / Splice: Sirt3em25Mcwi   Sirt3em4Mcwi   Sirt3em35Mcwi   Sirt3em30Mcwi  
Genetic Models: SS-Sirt3em25Mcwi T2DN-Sirt3em30Mcwi T2DN-Sirt3em35Mcwi SS-Sirt3em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Sirt3
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308374
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2017-12-05
Status: ACTIVE