Slc7a6 (solute carrier family 7 member 6) - Rat Genome Database

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Gene: Slc7a6 (solute carrier family 7 member 6) Rattus norvegicus
Analyze
Symbol: Slc7a6
Name: solute carrier family 7 member 6
RGD ID: 1309193
Description: Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in L-arginine transmembrane transport and nitric oxide biosynthetic process. Predicted to be located in plasma membrane. Orthologous to human SLC7A6 (solute carrier family 7 member 6); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307811; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; solute carrier family 7 (cationic amino acid transporter, y+ system), member 6; y(+)L-type amino acid transporter 2; Y+L amino acid transporter 2; y+LAT-2; Y+LAT2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,982,459 - 51,010,140 (+)NCBIGRCr8
mRatBN7.21934,073,472 - 34,100,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,074,286 - 34,100,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,899,201 - 40,915,837 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,552,514 - 41,569,150 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,851,657 - 43,868,294 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,152,225 - 38,179,149 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,162,515 - 38,179,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,013,758 - 49,045,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,032,750 - 36,049,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,027,483 - 36,054,258 (+)NCBI
Celera1933,510,719 - 33,527,353 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
estriol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
heptachlor  (EXP)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mirex  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. Zielinska M, etal., J Neurochem. 2015 Dec;135(6):1272-81. doi: 10.1111/jnc.13387. Epub 2015 Nov 6.
6. Upregulation of the heteromeric y⁺LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes. Zielińska M, etal., Neurochem Int. 2012 Sep;61(4):531-5. doi: 10.1016/j.neuint.2012.02.021. Epub 2012 Feb 27.
Additional References at PubMed
PMID:17197568  


Genomics

Comparative Map Data
Slc7a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,982,459 - 51,010,140 (+)NCBIGRCr8
mRatBN7.21934,073,472 - 34,100,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,074,286 - 34,100,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,899,201 - 40,915,837 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,552,514 - 41,569,150 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,851,657 - 43,868,294 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,152,225 - 38,179,149 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,162,515 - 38,179,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,013,758 - 49,045,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,032,750 - 36,049,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,027,483 - 36,054,258 (+)NCBI
Celera1933,510,719 - 33,527,353 (+)NCBICelera
Cytogenetic Map19q12NCBI
SLC7A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,264,526 - 68,301,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,264,516 - 68,301,823 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,298,429 - 68,335,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,855,924 - 66,893,223 (+)NCBINCBI36Build 36hg18NCBI36
Build 341666,855,933 - 66,893,222NCBI
Celera1652,806,916 - 52,844,230 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1654,171,419 - 54,208,888 (+)NCBIHuRef
CHM1_11669,706,452 - 69,743,751 (+)NCBICHM1_1
T2T-CHM13v2.01674,060,279 - 74,097,601 (+)NCBIT2T-CHM13v2.0
Slc7a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,894,718 - 106,925,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,895,489 - 106,925,338 (+)EnsemblGRCm39 Ensembl
GRCm388106,168,219 - 106,198,714 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,168,857 - 106,198,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,692,775 - 108,722,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368109,058,004 - 109,087,833 (+)NCBIMGSCv36mm8
Celera8110,396,649 - 110,426,481 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.1NCBI
Slc7a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,349,622 - 8,383,475 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,335,508 - 8,383,814 (-)NCBIChiLan1.0ChiLan1.0
SLC7A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,811,895 - 77,848,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,722,908 - 83,759,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,641,256 - 48,675,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,037,206 - 68,072,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,038,696 - 68,072,502 (+)Ensemblpanpan1.1panPan2
SLC7A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,229,251 - 81,267,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,231,680 - 81,252,295 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,219,398 - 81,257,388 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,664,241 - 81,702,242 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,664,376 - 81,699,724 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,490,980 - 81,528,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,173,484 - 81,211,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,814,920 - 81,852,921 (-)NCBIUU_Cfam_GSD_1.0
Slc7a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,965,655 - 41,002,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,586,931 - 18,625,137 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,587,058 - 18,624,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1628,834,797 - 28,876,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,118,131 - 59,164,659 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,119,827 - 59,143,982 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604721,852,528 - 21,892,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,013,340 - 18,032,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,009,078 - 18,046,072 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a6
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:533
Count of miRNA genes:256
Interacting mature miRNAs:333
Transcripts:ENSRNOT00000027117
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
BF390435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,095,265 - 34,095,417 (+)MAPPERmRatBN7.2
Rnor_6.01938,174,147 - 38,174,298NCBIRnor6.0
Rnor_5.01949,040,947 - 49,041,098UniSTSRnor5.0
RGSC_v3.41936,044,382 - 36,044,533UniSTSRGSC3.4
Celera1933,522,351 - 33,522,502UniSTS
RH 3.4 Map19316.7UniSTS
Cytogenetic Map19q12UniSTS
RH131633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,100,012 - 34,100,205 (+)MAPPERmRatBN7.2
Rnor_6.01938,178,894 - 38,179,086NCBIRnor6.0
Rnor_5.01949,045,694 - 49,045,886UniSTSRnor5.0
RGSC_v3.41936,049,129 - 36,049,321UniSTSRGSC3.4
Celera1933,527,098 - 33,527,290UniSTS
RH 3.4 Map6686.1UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 15 6 19 6 74 20 41 11
Low 1 13 41 34 34 8 11 15 8
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010059998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010059999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000027117   ⟹   ENSRNOP00000027117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,074,286 - 34,100,255 (+)Ensembl
Rnor_6.0 Ensembl1938,162,515 - 38,179,149 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094705   ⟹   ENSRNOP00000078355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,074,452 - 34,100,268 (+)Ensembl
RefSeq Acc Id: NM_001107424   ⟹   NP_001100894
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,993,506 - 51,010,140 (+)NCBI
mRatBN7.21934,083,633 - 34,100,268 (+)NCBI
Rnor_6.01938,162,515 - 38,179,149 (+)NCBI
Rnor_5.01949,013,758 - 49,045,949 (+)NCBI
RGSC_v3.41936,032,750 - 36,049,384 (+)RGD
Celera1933,510,719 - 33,527,353 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255498   ⟹   XP_006255560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,413 - 51,010,135 (+)NCBI
mRatBN7.21934,074,353 - 34,100,263 (+)NCBI
Rnor_6.01938,153,254 - 38,179,147 (+)NCBI
Rnor_5.01949,013,758 - 49,045,949 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255500   ⟹   XP_006255562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,315 - 51,010,135 (+)NCBI
mRatBN7.21934,074,353 - 34,100,263 (+)NCBI
Rnor_6.01938,153,254 - 38,179,147 (+)NCBI
Rnor_5.01949,013,758 - 49,045,949 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772500   ⟹   XP_008770722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,982,459 - 51,010,135 (+)NCBI
mRatBN7.21934,074,193 - 34,100,263 (+)NCBI
Rnor_6.01938,153,123 - 38,179,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772501   ⟹   XP_008770723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,982,461 - 51,010,135 (+)NCBI
mRatBN7.21934,073,472 - 34,100,263 (+)NCBI
Rnor_6.01938,152,225 - 38,179,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772502   ⟹   XP_008770724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,983,911 - 51,010,135 (+)NCBI
mRatBN7.21934,074,034 - 34,100,263 (+)NCBI
Rnor_6.01938,152,615 - 38,179,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097743   ⟹   XP_038953671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,983,665 - 51,010,135 (+)NCBI
mRatBN7.21934,073,761 - 34,100,263 (+)NCBI
RefSeq Acc Id: XM_039097744   ⟹   XP_038953672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,983,444 - 51,010,135 (+)NCBI
mRatBN7.21934,073,571 - 34,100,263 (+)NCBI
RefSeq Acc Id: XM_039097745   ⟹   XP_038953673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,983,664 - 51,010,135 (+)NCBI
mRatBN7.21934,073,760 - 34,100,263 (+)NCBI
RefSeq Acc Id: XM_039097746   ⟹   XP_038953674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,993,506 - 51,006,693 (+)NCBI
mRatBN7.21934,074,353 - 34,096,838 (+)NCBI
RefSeq Acc Id: XM_063278036   ⟹   XP_063134106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,072 - 51,010,135 (+)NCBI
RefSeq Acc Id: XM_063278037   ⟹   XP_063134107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,235 - 51,010,135 (+)NCBI
RefSeq Acc Id: XM_063278038   ⟹   XP_063134108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,161 - 51,010,135 (+)NCBI
RefSeq Acc Id: XM_063278039   ⟹   XP_063134109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,003,838 - 51,010,135 (+)NCBI
RefSeq Acc Id: XM_063278040   ⟹   XP_063134110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,001,636 - 51,010,135 (+)NCBI
RefSeq Acc Id: XM_063278041   ⟹   XP_063134111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,001,535 - 51,010,135 (+)NCBI
RefSeq Acc Id: XR_010059998
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,982,459 - 51,010,135 (+)NCBI
RefSeq Acc Id: XR_010059999
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,072 - 51,010,135 (+)NCBI
RefSeq Acc Id: XR_010060000
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,990,692 - 51,005,095 (+)NCBI
RefSeq Acc Id: XR_010060001
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,982,459 - 51,010,135 (+)NCBI
RefSeq Acc Id: XR_010060002
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,990,688 - 51,005,095 (+)NCBI
RefSeq Acc Id: XR_597221
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,984,399 - 51,010,135 (+)NCBI
mRatBN7.21934,074,353 - 34,100,263 (+)NCBI
Rnor_6.01938,153,254 - 38,179,147 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001100894   ⟸   NM_001107424
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255560   ⟸   XM_006255498
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255562   ⟸   XM_006255500
- Peptide Label: isoform X3
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770723   ⟸   XM_008772501
- Peptide Label: isoform X3
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770724   ⟸   XM_008772502
- Peptide Label: isoform X3
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770722   ⟸   XM_008772500
- Peptide Label: isoform X3
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027117   ⟸   ENSRNOT00000027117
RefSeq Acc Id: XP_038953672   ⟸   XM_039097744
- Peptide Label: isoform X3
- UniProtKB: D3ZMM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953673   ⟸   XM_039097745
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953671   ⟸   XM_039097743
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953674   ⟸   XM_039097746
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000078355   ⟸   ENSRNOT00000094705
RefSeq Acc Id: XP_063134106   ⟸   XM_063278036
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063134108   ⟸   XM_063278038
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063134107   ⟸   XM_063278037
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063134111   ⟸   XM_063278041
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063134110   ⟸   XM_063278040
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063134109   ⟸   XM_063278039
- Peptide Label: isoform X7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMM8-F1-model_v2 AlphaFold D3ZMM8 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309193 AgrOrtholog
BioCyc Gene G2FUF-5785 BioCyc
Ensembl Genes ENSRNOG00000019943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018321 UniProtKB/Swiss-Prot
  ENSRNOG00060012645 UniProtKB/Swiss-Prot
  ENSRNOG00065012197 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027117.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094705.1 UniProtKB/TrEMBL
  ENSRNOT00055031095 UniProtKB/Swiss-Prot
  ENSRNOT00060021487 UniProtKB/Swiss-Prot
  ENSRNOT00065019827 UniProtKB/Swiss-Prot
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:307811 UniProtKB/Swiss-Prot
NCBI Gene 307811 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y+L AMINO ACID TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc7a6 PhenoGen
PIRSF AA_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019943 RatGTEx
  ENSRNOG00055018321 RatGTEx
  ENSRNOG00060012645 RatGTEx
  ENSRNOG00065012197 RatGTEx
UniProt A0A8I5ZKR1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMM8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc7a6  solute carrier family 7 member 6  Slc7a6  solute carrier family 7 (amino acid transporter light chain, y+L system), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Slc7a6  solute carrier family 7 (amino acid transporter light chain, y+L system), member 6  Slc7a6  solute carrier family 7 (cationic amino acid transporter, y+ system), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc7a6  solute carrier family 7 (cationic amino acid transporter, y+ system), member 6   Slc7a6_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc7a6_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED