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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bilirubin IXalpha
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Accession:CHEBI:16990 term browser browse the term
Definition:A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Synonyms:related_synonym: 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid;   2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid;   2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid;   8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione;   Bilirubin;   Formula=C33H36N4O6;   InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-;   InChIKey=BPYKTIZUTYGOLE-IFADSCNNSA-N;   SMILES=CC1=C(C=C)\\C(NC1=O)=C\\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\\C=C2/NC(=O)C(C=C)=C2C)N1;   bilirubin(Z,Z)
 alt_id: CHEBI:13898;   CHEBI:22870;   CHEBI:3099
 xref: Beilstein:74376;   CAS:635-65-4;   Gmelin:411033;   HMDB:HMDB0000054;   KEGG:C00486;   KNApSAcK:C00029828
 xref_mesh: MESH:D001663
 xref: MetaCyc:BILIRUBIN;   PDBeChem:BLR;   PMID:12799017;   PMID:18442622;   PMID:23763371;   PMID:23768684;   PMID:30224965;   PMID:8605219;   PMID:9587403;   Reaxys:74376;   Wikipedia:Bilirubin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57977


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bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein] CTD PMID:24306262 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
multiple interactions		 ISO ABCC1 protein affects the transport of Bilirubin
Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]		 CTD PMID:15245331 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
affects transport
multiple interactions		 EXP Bilirubin results in decreased activity of ABCC2 protein
ABCC2 protein affects the transport of Bilirubin
Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein]		 CTD PMID:15374814 PMID:15901347 PMID:24306262 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [[Bilirubin binds to and results in increased activity of AHR protein] which binds to CYP1A promoter] which results in increased expression of CYP1A mRNA CTD PMID:18187559 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Bilirubin results in decreased expression of ALAD mRNA CTD PMID:20196124 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO
EXP		 ALB protein binds to Bilirubin; Bilirubin binds to ALB protein
[homocysteine thiolactone results in increased metabolism of ALB protein] affects the reaction [ALB protein binds to Bilirubin]; Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein]
Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]		 CTD PMID:21280114 PMID:33788065 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Anxa1 annexin A1 decreases expression ISO Bilirubin results in decreased expression of ANXA1 mRNA CTD PMID:20196124 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Areg amphiregulin increases expression ISO Bilirubin results in increased expression of AREG mRNA CTD PMID:20196124 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Bilirubin results in decreased expression of ARHGAP29 mRNA CTD PMID:20196124 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028 		JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Bilirubin results in decreased expression of ASB13 mRNA CTD PMID:20196124 NCBI chr17:66,564,653...66,583,365
Ensembl chr17:66,562,434...66,583,337 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bilirubin results in increased expression of ATF3 mRNA CTD PMID:20196124 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 ISO Bilirubin results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA]		 CTD PMID:27578021 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression ISO Bilirubin results in decreased expression of ATP1A1 mRNA CTD PMID:20196124 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Axin2 axin 2 decreases expression ISO Bilirubin results in decreased expression of AXIN2 mRNA CTD PMID:20196124 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO Bilirubin results in decreased expression of BLOC1S1 mRNA CTD PMID:20196124 NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,340,934...1,351,558 		JBrowse link
G C1d C1D nuclear receptor corepressor decreases expression ISO Bilirubin results in decreased expression of C1D mRNA CTD PMID:20196124 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO
EXP		 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
Bilirubin results in increased activity of CASP3 protein		 CTD PMID:20709802 PMID:23628428 PMID:27578021 PMID:28805483 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression ISO Bilirubin results in decreased expression of CAT mRNA CTD PMID:20196124 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression ISO Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Bilirubin results in decreased expression of CCND1 mRNA CTD PMID:20196124 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd302 CD302 molecule decreases expression ISO Bilirubin results in decreased expression of CD302 mRNA CTD PMID:20196124 NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Bilirubin results in increased expression of CHAC1 mRNA CTD PMID:20196124 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Chka choline kinase alpha increases expression ISO Bilirubin results in increased expression of CHKA mRNA CTD PMID:20196124 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Clcc1 chloride channel CLIC-like 1 decreases expression ISO Bilirubin results in decreased expression of CLCC1 mRNA CTD PMID:20196124 NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Bilirubin results in decreased expression of CLIP1 mRNA CTD PMID:20196124 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Bilirubin results in decreased expression of COL3A1 mRNA CTD PMID:20196124 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Bilirubin results in decreased expression of COX15 mRNA CTD PMID:20196124 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cpd carboxypeptidase D decreases expression ISO Bilirubin results in decreased expression of CPD mRNA CTD PMID:20196124 NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Bilirubin results in increased expression of CSF2 mRNA CTD PMID:20196124 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctsh cathepsin H decreases expression ISO Bilirubin results in decreased expression of CTSH mRNA CTD PMID:20196124 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Bilirubin results in increased expression of CXCL10 mRNA CTD PMID:20196124 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Bilirubin results in increased expression of CXCL11 mRNA CTD PMID:20196124 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Bilirubin results in increased expression of CXCL2 mRNA CTD PMID:20196124 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Bilirubin results in increased expression of CYP1A1 mRNA; Bilirubin results in increased expression of CYP1A1 protein CTD PMID:20196124 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Bilirubin results in decreased activity of CYP1A2 protein CTD PMID:16183037 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO Bilirubin results in increased expression of CYP2B6 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]		 CTD PMID:15382119 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO
EXP		 Bilirubin results in increased expression of CYP3A4 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]
[CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Bilirubin		 CTD PMID:15382119 PMID:34461081 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Bilirubin CTD PMID:34461081 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases activity		 EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Bilirubin results in decreased activity of CYP7A1 protein		 CTD PMID:12700418 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Bilirubin results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; [Bilirubin co-treated with Rotenone] promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]		 CTD PMID:20196124 PMID:27578021 PMID:32033040 PMID:37054934 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression ISO Bilirubin results in decreased expression of DEPTOR mRNA CTD PMID:20196124 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773 		JBrowse link
G Dmkn dermokine decreases expression ISO Bilirubin results in decreased expression of DMKN mRNA CTD PMID:20196124 NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Bilirubin affects the expression of DNAJB1 mRNA CTD PMID:20196124 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dnpep aspartyl aminopeptidase decreases expression ISO Bilirubin results in decreased expression of DNPEP mRNA CTD PMID:20196124 NCBI chr 9:76,799,931...76,808,841
Ensembl chr 9:76,783,966...76,808,716 		JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO Bilirubin results in decreased expression of DPY19L1 mRNA CTD PMID:20196124 NCBI chr 8:22,933,163...23,021,461
Ensembl chr 8:22,933,163...23,021,751 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Bilirubin results in increased expression of DUSP5 mRNA CTD PMID:20196124 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein] CTD PMID:27297870 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Bilirubin results in decreased expression of EGLN1 mRNA CTD PMID:20196124 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Bilirubin results in decreased expression of EI24 mRNA CTD PMID:20196124 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO Bilirubin results in decreased expression of EID1 mRNA CTD PMID:20196124 NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions ISO [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin CTD PMID:25411909 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124 PMID:27578021 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein CTD PMID:20196124 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Bilirubin results in decreased expression of ENDOD1 mRNA CTD PMID:20196124 NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892 		JBrowse link
G Fam174a family with sequence similarity 174, member A decreases expression ISO Bilirubin results in decreased expression of FAM174A mRNA CTD PMID:20196124 NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:95,742,927...95,761,081 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF15 gene mutant form results in increased abundance of Bilirubin CTD PMID:24699334 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Bilirubin results in increased expression of FOSL1 mRNA CTD PMID:20196124 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Bilirubin results in increased expression of GADD45B mRNA CTD PMID:20196124 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO Bilirubin results in decreased expression of GAS5 mRNA CTD PMID:20196124 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gsn gelsolin decreases expression ISO Bilirubin results in decreased expression of GSN mRNA CTD PMID:20196124 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions		 ISO Bilirubin results in increased expression of GSTA1 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]		 CTD PMID:15382119 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
multiple interactions
affects binding		 ISO
EXP		 Bilirubin results in increased expression of GSTA2 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]
Bilirubin binds to GSTA2 protein		 CTD PMID:1148165 PMID:2768223 PMID:15382119 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO Bilirubin results in decreased expression of GSTA4 mRNA CTD PMID:20196124 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Bilirubin results in decreased expression of GSTK1 mRNA CTD PMID:20196124 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Bilirubin results in decreased expression of GSTM1 mRNA CTD PMID:20196124 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Bilirubin results in decreased expression of GSTP1 mRNA CTD PMID:20196124 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Bilirubin results in increased expression of H1-4 mRNA CTD PMID:20196124 NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403 		JBrowse link
G H2ac25 H2A clustered histone 25 increases expression ISO Bilirubin results in increased expression of H2AC25 mRNA CTD PMID:20196124 NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874 		JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 decreases expression ISO Bilirubin results in decreased expression of HACD4 mRNA CTD PMID:20196124 NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338 		JBrowse link
G Heph hephaestin decreases expression ISO Bilirubin results in decreased expression of HEPH mRNA CTD PMID:20196124 NCBI chr  X:61,151,131...61,402,980
Ensembl chr  X:61,296,345...61,402,980 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Bilirubin results in increased expression of HERPUD1 mRNA CTD PMID:20196124 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] CTD PMID:27297870 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Bilirubin results in increased expression of H4C9 mRNA CTD PMID:20196124 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases abundance
affects activity
increases expression
increases chemical synthesis		 EXP
ISO		 [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin
HMOX1 protein results in increased abundance of Bilirubin
[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
Bilirubin affects the activity of HMOX1 protein
Bilirubin results in increased expression of HMOX1 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]		 CTD PMID:12690112 PMID:15226216 PMID:15602829 PMID:20196124 PMID:21401295 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 affects abundance ISO HMOX2 affects the abundance of Bilirubin CTD PMID:16181104 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO
EXP		 Bilirubin results in increased expression of HSPA5 mRNA; Bilirubin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; Bilirubin inhibits the reaction [[Cannabidiol co-treated with Rotenone] results in increased expression of HSPA5 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]		 CTD PMID:20196124 PMID:27578021 PMID:32033040 PMID:37054934 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Bilirubin results in increased expression of IFRD1 mRNA CTD PMID:20196124 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Bilirubin results in decreased expression of IGFBP3 mRNA CTD PMID:20196124 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance		 ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Bilirubin results in decreased susceptibility to IL18 protein		 CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]		 CTD PMID:15382119 PMID:18206168 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Bilirubin results in increased expression of IL6 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]		 CTD PMID:20196124 PMID:32033040 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kl Klotho decreases expression EXP Bilirubin results in decreased expression of KL mRNA; Bilirubin results in decreased expression of KL protein CTD PMID:28805483 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Bilirubin results in decreased expression of LAMB1 mRNA CTD PMID:20196124 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Bilirubin results in decreased expression of LAMP2 mRNA CTD PMID:20196124 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Leprot leptin receptor overlapping transcript decreases expression ISO Bilirubin results in decreased expression of LEPROT mRNA CTD PMID:20196124 NCBI chr 5:116,289,843...116,301,951
Ensembl chr 5:116,289,822...116,301,988 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Bilirubin results in increased expression of LIF mRNA CTD PMID:20196124 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Bilirubin results in decreased expression of LRP1 mRNA CTD PMID:20196124 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Ly6al1 lymphocyte antigen 6 complex, locus A like 1 decreases expression ISO Bilirubin results in decreased expression of LY6A mRNA CTD PMID:20196124 NCBI chr 7:107,011,585...107,018,125
Ensembl chr 7:107,011,623...107,015,179 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Bilirubin results in decreased expression of MAF mRNA CTD PMID:20196124 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK1 protein CTD PMID:12690112 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK3 protein CTD PMID:12690112 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Bilirubin results in decreased expression of MAPRE2 mRNA CTD PMID:20196124 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044 		JBrowse link
G Me2 malic enzyme 2 decreases expression ISO Bilirubin results in decreased expression of ME2 mRNA CTD PMID:20196124 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987 		JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO Bilirubin results in decreased expression of MEGF9 mRNA CTD PMID:20196124 NCBI chr 5:83,993,565...84,105,622
Ensembl chr 5:83,993,565...84,105,622 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases secretion ISO MET gene mutant form results in increased secretion of Bilirubin CTD PMID:27394961 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Bilirubin results in decreased expression of MGST2 mRNA CTD PMID:20196124 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Bilirubin results in increased expression of MMP13 mRNA CTD PMID:20196124 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression ISO Bilirubin results in decreased expression of MPZL2 mRNA CTD PMID:20196124 NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298 		JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO Bilirubin results in decreased expression of MRPL18 mRNA CTD PMID:20196124 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO Bilirubin affects the localization of NFE2L2 protein
Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA]		 CTD PMID:23628428 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 mRNA] CTD PMID:37054934 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nid1 nidogen 1 decreases expression ISO Bilirubin results in decreased expression of NID1 mRNA CTD PMID:20196124 NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Bilirubin results in decreased expression of NNT mRNA CTD PMID:20196124 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823 		JBrowse link
G Noct nocturnin increases expression ISO Bilirubin results in increased expression of NOCT mRNA CTD PMID:20196124 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18206168 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
affects abundance
affects transport		 ISO Bilirubin results in increased expression of NR1I2 mRNA
NR1I2 protein affects the abundance of Bilirubin
NR1I2 protein affects the transport of Bilirubin		 CTD PMID:15726644 PMID:18706437 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bilirubin results in increased expression of NR1I3 mRNA CTD PMID:18706437 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Bilirubin results in increased expression of OSGIN1 mRNA CTD PMID:20196124 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 ISO Bilirubin results in increased expression of PARP1 protein modified form
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form]		 CTD PMID:27578021 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Bilirubin results in decreased expression of PDK1 mRNA CTD PMID:20196124 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Bilirubin results in decreased expression of PGAP2 mRNA CTD PMID:20196124 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114 		JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Bilirubin results in decreased expression of PHB1 mRNA CTD PMID:20196124 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pla1a phospholipase A1 member A decreases expression ISO Bilirubin results in decreased expression of PLA1A mRNA CTD PMID:20196124 NCBI chr11:62,320,112...62,357,779
Ensembl chr11:62,320,493...62,357,779 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO Bilirubin results in decreased expression of PMP22 mRNA CTD PMID:20196124 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Bilirubin results in decreased expression of PON2 mRNA CTD PMID:20196124 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rassf4 Ras association domain family member 4 increases expression ISO Bilirubin results in increased expression of RASSF4 mRNA CTD PMID:20196124 NCBI chr 4:149,897,525...149,932,658
Ensembl chr 4:149,897,543...149,932,411 		JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression ISO Bilirubin results in decreased expression of RBM39 mRNA CTD PMID:20196124 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213 		JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Bilirubin results in decreased expression of RBM5 mRNA CTD PMID:20196124 NCBI chr 8:108,420,220...108,449,481
Ensembl chr 8:108,420,222...108,449,430 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Bilirubin results in increased expression of RELA mRNA CTD PMID:27578021 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 decreases expression ISO Bilirubin results in decreased expression of RHOBTB3 mRNA CTD PMID:20196124 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041 		JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression ISO Bilirubin results in decreased expression of RNASE4 mRNA CTD PMID:20196124 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117 		JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Bilirubin results in decreased expression of S100A10 mRNA CTD PMID:20196124 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO Bilirubin results in decreased expression of S100A4 mRNA CTD PMID:20196124 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Scp2 sterol carrier protein 2 decreases expression ISO Bilirubin results in decreased expression of SCP2 mRNA CTD PMID:20196124 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Bilirubin results in decreased expression of SELENBP1 mRNA CTD PMID:20196124 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Bilirubin results in decreased expression of SERPINB1A mRNA CTD PMID:20196124 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Bilirubin results in increased expression of SERPINE1 mRNA CTD PMID:20196124 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sesn1 sestrin 1 decreases expression ISO Bilirubin results in decreased expression of SESN1 mRNA CTD PMID:20196124 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Bilirubin results in decreased expression of SGPP1 mRNA CTD PMID:20196124 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534 		JBrowse link
G Slc16a12 solute carrier family 16, member 12 decreases expression ISO Bilirubin results in decreased expression of SLC16A12 mRNA CTD PMID:20196124 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141 		JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Bilirubin results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Bilirubin results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression		 ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC3A2 mRNA		 CTD PMID:22216172 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression		 ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC7A11 mRNA		 CTD PMID:22216172 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Snx14 sorting nexin 14 decreases expression ISO Bilirubin results in decreased expression of SNX14 mRNA CTD PMID:20196124 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580 		JBrowse link
G Sost sclerostin decreases expression ISO Bilirubin results in decreased expression of SOST mRNA CTD PMID:20196124 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Bilirubin results in decreased expression of SP5 mRNA CTD PMID:20196124 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733 		JBrowse link
G Tapbp TAP binding protein decreases expression ISO Bilirubin results in decreased expression of TAPBP mRNA CTD PMID:20196124 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181 		JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO Bilirubin results in decreased expression of TCF4 mRNA CTD PMID:20196124 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 decreases expression EXP Bilirubin results in decreased expression of TET1 mRNA; Bilirubin results in decreased expression of TET1 protein CTD PMID:28805483 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Bilirubin results in increased expression of TIPARP mRNA CTD PMID:20196124 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Bilirubin results in decreased expression of TM9SF2 mRNA CTD PMID:20196124 NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]
Bilirubin results in increased expression of TNF mRNA; Bilirubin results in increased expression of TNF protein		 CTD PMID:27578021 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 decreases expression ISO Bilirubin results in decreased expression of TNFRSF19 mRNA CTD PMID:20196124 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases expression ISO Bilirubin results in decreased expression of TPP1 mRNA CTD PMID:20196124 NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129 		JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Bilirubin results in decreased expression of TRIB2 mRNA CTD PMID:20196124 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
decreases activity
multiple interactions
decreases glucuronidation
increases glucuronidation
increases metabolic processing		 ISO
EXP		 Bilirubin results in increased expression of UGT1A1 mRNA
Bilirubin results in decreased activity of UGT1A1 protein
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin
UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin
UGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of Bilirubin
UGT1A1 protein results in increased metabolism of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]		 CTD PMID:10950852 PMID:12153725 PMID:15334623 PMID:15382119 PMID:15557560 More... NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Bilirubin results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI decreases expression ISO Bilirubin results in decreased expression of UQCR11 mRNA CTD PMID:20196124 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein decreases expression ISO Bilirubin results in decreased expression of UQCRB mRNA CTD PMID:20196124 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Bilirubin results in decreased expression of UQCRH mRNA CTD PMID:20196124 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO Bilirubin results in decreased expression of UXS1 mRNA CTD PMID:20196124 NCBI chr 9:653,740...731,121
Ensembl chr 9:653,659...756,334 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Bilirubin results in decreased expression of VLDLR mRNA CTD PMID:20196124 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [VWF protein affects the susceptibility to 1-Naphthylisothiocyanate] which affects the abundance of Bilirubin CTD PMID:34619301 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions		 ISO
EXP		 Bilirubin results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of XBP1 mRNA alternative form]		 CTD PMID:27578021 PMID:37054934 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Bilirubin results in decreased expression of ZBTB20 mRNA CTD PMID:20196124 NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210 		JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases expression ISO Bilirubin results in decreased expression of ZBTB8OS mRNA CTD PMID:20196124 NCBI chr 5:141,675,595...141,687,148
Ensembl chr 5:141,675,857...141,688,660 		JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 decreases expression ISO Bilirubin results in decreased expression of ZCCHC7 mRNA CTD PMID:20196124 NCBI chr 5:58,992,558...59,173,308
Ensembl chr 5:58,993,290...59,173,300 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Bilirubin results in increased expression of ZFAND2A mRNA CTD PMID:20196124 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Bilirubin results in decreased expression of ZFP207 mRNA CTD PMID:20196124 NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386 		JBrowse link
G Zfp62 zinc finger protein 62 decreases expression ISO Bilirubin results in decreased expression of ZFP53 mRNA CTD PMID:20196124 NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        24G7 epitope 172
          bilirubin IXalpha 172
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organonitrogen heterocyclic compound 18126
                                    polypyrrole 698
                                      tetrapyrrole 585
                                        linear tetrapyrrole 174
                                          biladienes 172
                                            bilirubin IXalpha 172
paths to the root