Gene: Sost (sclerostin) Rattus norvegicus
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Symbol: Sost
Name: sclerostin
Description: ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN ossification; cellular response to parathyroid hormone stimulus (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Craniodiaphyseal Dysplasia, Autosomal Dominant (ortholog); craniometaphyseal dysplasia (ortholog); midface dysplasia (ortholog); FOUND IN extracellular space; Golgi apparatus; protein complex; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; aflatoxin B1; ammonium chloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: sclerosteosis
Orthologs:
Homo sapiens (human) : SOST (sclerostin)  HGNC  AGR
Mus musculus (house mouse) : Sost (sclerostin)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Sost (sclerostin)
Pan paniscus (bonobo/pygmy chimpanzee) : SOST (sclerostin)
Canis lupus familiaris (dog) : SOST (sclerostin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sost (sclerostin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBI
Cytogenetic Map10q32.1NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sost
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
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Vista + UCSC

RGD Object Information
RGD ID: 69358
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE