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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:estrogen signaling pathway
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Accession:PW:0000507 term browser browse the term
Definition:Estrogens are C18 steroid hormones that constitute the females sex hormones. Estrogens signal via the estrogen receptor which, once activated, drives the expression of target genes.
Synonyms:related_synonym: ESR-mediated signaling;   intracellular estrogen receptor signaling pathway
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estrogen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascc1 activating signal cointegrator 1 complex subunit 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr20:28,484,044...28,574,195
Ensembl chr20:28,483,956...28,574,200 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:28,373,362...28,418,056 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Ddx5 DEAD-box helicase 5 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:92,224,393...92,231,928
Ensembl chr10:92,224,395...92,231,300 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 ISO RGD PMID:18451092 RGD:4892102 NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120 		JBrowse link
G Ep300 EP300 lysine acetyltransferase ISO RGD PMID:16394250 RGD:5128512 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Esr1 estrogen receptor 1 ISO
IDA 		RGD PMID:16651458 PMID:19274700 PMID:17928626 RGD:1580338, RGD:4892064, RGD:5128669 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 IDA
ISO 		RGD PMID:15564578 PMID:19274700 PMID:17928626 RGD:1582269, RGD:4892064, RGD:5128669 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO
IDA
IMP 		RGD PMID:19274700 PMID:20445128 PMID:19767412 PMID:20445128 RGD:4892064, RGD:4892084, RGD:5128698, RGD:4892084 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO RGD PMID:18451092 RGD:4892102 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835 		JBrowse link
G Med1 mediator complex subunit 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO
IDA 		RGD PMID:16394250 PMID:11713241 RGD:5128512, RGD:727330 NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631 		JBrowse link
G Ncoa6 nuclear receptor coactivator 6 ISO
IDA 		RGD PMID:16394250 PMID:10866662 RGD:5128512, RGD:633378 NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:164,351,062...164,421,991 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353 		JBrowse link
G Phb2 prohibitin 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:159,203,926...159,209,231 		JBrowse link
G Ppid peptidylprolyl isomerase D ISO RGD PMID:18451092 RGD:4892102 NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:167,025,931...167,054,493 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 7:1,075,230...1,092,363
Ensembl chr 7:1,075,227...1,092,695 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873 		JBrowse link
G Sra1 steroid receptor RNA activator 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr18:28,543,347...28,547,474
Ensembl chr18:28,543,348...28,546,575 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IMP RGD PMID:17928626 PMID:20445128 RGD:5128669, RGD:4892084 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      transcription factor mediated signaling pathway 445
        estrogen signaling pathway 30
          altered estrogen signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      hormone signaling pathway 623
        lipid hormone signaling pathway 224
          steroid hormone signaling pathway 92
            sex steroids signaling pathway 34
              estrogen signaling pathway 30
                altered estrogen signaling pathway 0
paths to the root