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Gene: Ncoa6 (nuclear receptor coactivator 6) Rattus norvegicus
Symbol: Ncoa6
Name: nuclear receptor coactivator 6
Description: Exhibits several functions, including nuclear hormone receptor binding activity; nuclear receptor transcription coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Localizes to the nucleus and protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6); PARTICIPATES IN estrogen signaling pathway; histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activating signal cointegrator 2; Aib3; amplified in breast cancer protein 3; ASC-2; cancer-amplified transcriptional coactivator ASC-2; NRC; nuclear receptor coactivator RAP250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; thyroid hormone receptor binding protein; thyroid hormone receptor-binding protein; Trbp
Homo sapiens (human) : NCOA6 (nuclear receptor coactivator 6)  HGNC  Alliance
Mus musculus (house mouse) : Ncoa6 (nuclear receptor coactivator 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncoa6 (nuclear receptor coactivator 6)
Pan paniscus (bonobo/pygmy chimpanzee) : NCOA6 (nuclear receptor coactivator 6)
Canis lupus familiaris (dog) : NCOA6 (nuclear receptor coactivator 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncoa6 (nuclear receptor coactivator 6)
Sus scrofa (pig) : NCOA6 (nuclear receptor coactivator 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)Ensembl
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBICelera
Cytogenetic Map3q41-q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ncoa6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620111
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.