Ncoa6 (nuclear receptor coactivator 6) - Rat Genome Database

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Gene: Ncoa6 (nuclear receptor coactivator 6) Rattus norvegicus
Analyze
Symbol: Ncoa6
Name: nuclear receptor coactivator 6
RGD ID: 620111
Description: Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6); PARTICIPATES IN estrogen signaling pathway; histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating signal cointegrator 2; Aib3; amplified in breast cancer protein 3; ASC-2; cancer-amplified transcriptional coactivator ASC-2; NRC; nuclear receptor coactivator RAP250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; thyroid hormone receptor binding protein; thyroid hormone receptor-binding protein; Trbp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23143,890,896 - 143,961,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,757,713 - 147,797,978 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03156,374,984 - 156,415,249 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03154,114,516 - 154,154,781 (-)NCBIRnor_WKY
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBICelera
Cytogenetic Map3q41-q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Antonson P, etal., Mol Cell Biol 2003 Feb;23(4):1260-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
5. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Ko L, etal., Proc Natl Acad Sci U S A 2000 May 23;97(11):6212-7.
6. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. Lee SK, etal., J Biol Chem. 1999 Nov 26;274(48):34283-93.
7. Expression and localization of RAP250 mRNA in rat ovary: possible implications in follicular development and ovulation. Liu DL, etal., Endocrine. 2002 Jul;18(2):173-8.
8. A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mahajan MA and Samuels HH, Mol Cell Biol 2000 Jul;20(14):5048-63.
9. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Mahajan MA, etal., Mol Cell Biol 2002 Oct;22(19):6883-94.
10. Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling. Mahajan MA, etal., Mol Endocrinol. 2007 Aug;21(8):1822-34. Epub 2007 May 29.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
16. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
17. Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Yeom SY, etal., Mol Cell Biol. 2006 Jun;26(12):4553-63.
Additional References at PubMed
PMID:10681503   PMID:10788465   PMID:11302752   PMID:11443112   PMID:12039952   PMID:12368298   PMID:12446761   PMID:17021013   PMID:17500065   PMID:21700703   PMID:22311984   PMID:23341457  
PMID:29263199  


Genomics

Comparative Map Data
Ncoa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23143,890,896 - 143,961,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,757,713 - 147,797,978 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03156,374,984 - 156,415,249 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03154,114,516 - 154,154,781 (-)NCBIRnor_WKY
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBICelera
Cytogenetic Map3q41-q42NCBI
NCOA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,714,774 - 34,825,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2034,689,097 - 34,825,651 (-)EnsemblGRCh38hg38GRCh38
GRCh372033,302,578 - 33,413,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,766,239 - 32,877,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 342032,766,238 - 32,877,094NCBI
Celera2030,051,663 - 30,162,529 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,081,569 - 30,192,220 (-)NCBIHuRef
CHM1_12033,204,060 - 33,314,823 (-)NCBICHM1_1
T2T-CHM13v2.02036,435,437 - 36,546,294 (-)NCBIT2T-CHM13v2.0
Ncoa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,232,576 - 155,315,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,232,576 - 155,315,814 (-)EnsemblGRCm39 Ensembl
GRCm382155,390,656 - 155,473,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,390,656 - 155,473,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,216,401 - 155,266,519 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,082,112 - 155,129,567 (-)NCBIMGSCv36mm8
Celera2161,323,189 - 161,373,222 (-)NCBICelera
Cytogenetic Map2H1NCBI
Ncoa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,564,037 - 26,632,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,564,535 - 26,639,516 (+)NCBIChiLan1.0ChiLan1.0
NCOA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12032,170,583 - 32,247,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,170,583 - 32,247,167 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02031,044,339 - 31,154,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NCOA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,802,360 - 23,877,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,802,351 - 23,866,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,447,946 - 23,539,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,493,126 - 24,584,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,493,113 - 24,581,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,780,970 - 23,872,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,876,107 - 23,967,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,314,983 - 24,406,060 (-)NCBIUU_Cfam_GSD_1.0
Ncoa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,766,751 - 172,862,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,906,485 - 5,982,268 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365615,905,905 - 5,982,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,114,291 - 38,221,901 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,114,284 - 38,221,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,309,959 - 43,393,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,013,364 - 39,129,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,013,232 - 39,129,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,702,887 - 87,819,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248424,570,758 - 4,665,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncoa6
265 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:107
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000024714, ENSRNOT00000074304
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 30 14 19 14 67 33 41 11
Low 15 27 27 27 8 11 7 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_591737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF176351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024714   ⟹   ENSRNOP00000024714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)Ensembl
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114206   ⟹   ENSRNOP00000093567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,894,869 - 143,952,268 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118396   ⟹   ENSRNOP00000097352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)Ensembl
RefSeq Acc Id: NM_001276714   ⟹   NP_001263643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,931,612 (-)NCBI
Rnor_6.03150,919,317 - 150,960,030 (-)NCBI
Rnor_5.03157,287,434 - 157,358,499 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235296   ⟹   XP_006235358
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
Rnor_6.03150,919,317 - 150,990,391 (-)NCBI
Rnor_5.03157,287,434 - 157,358,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762295   ⟹   XP_008760517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,930 - 143,961,916 (-)NCBI
Rnor_6.03150,919,317 - 150,990,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104103   ⟹   XP_038960031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104104   ⟹   XP_038960032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104105   ⟹   XP_038960033
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104106   ⟹   XP_038960034
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104107   ⟹   XP_038960035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XR_005501749
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,898,839 - 143,961,914 (-)NCBI
RefSeq Acc Id: XR_005501750
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23143,898,839 - 143,961,914 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001263643   ⟸   NM_001276714
- UniProtKB: G3V8C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235358   ⟸   XM_006235296
- Peptide Label: isoform X1
- UniProtKB: G3V8C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760517   ⟸   XM_008762295
- Peptide Label: isoform X1
- UniProtKB: G3V8C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024714   ⟸   ENSRNOT00000024714
RefSeq Acc Id: XP_038960033   ⟸   XM_039104105
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038960032   ⟸   XM_039104104
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960035   ⟸   XM_039104107
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960034   ⟸   XM_039104106
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ARE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960031   ⟸   XM_039104103
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000093567   ⟸   ENSRNOT00000114206
RefSeq Acc Id: ENSRNOP00000097352   ⟸   ENSRNOT00000118396
Protein Domains
Nucleic_acid_bd

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLI4-F1-model_v2 AlphaFold Q9JLI4 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620111 AgrOrtholog
BioCyc Gene G2FUF-47137 BioCyc
Ensembl Genes ENSRNOG00000018288 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024714 ENTREZGENE
  ENSRNOP00000024714.6 UniProtKB/TrEMBL
  ENSRNOP00000093567.1 UniProtKB/TrEMBL
  ENSRNOP00000097352 ENTREZGENE
  ENSRNOP00000097352.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024714 ENTREZGENE
  ENSRNOT00000024714.8 UniProtKB/TrEMBL
  ENSRNOT00000114206.1 UniProtKB/TrEMBL
  ENSRNOT00000118396 ENTREZGENE
  ENSRNOT00000118396.1 UniProtKB/TrEMBL
InterPro NCOA6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA6_nucleic_acid_bd UniProtKB/TrEMBL
KEGG Report rno:116464 UniProtKB/TrEMBL
NCBI Gene 116464 ENTREZGENE
PANTHER PTHR15690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nucleic_acid_bd UniProtKB/TrEMBL
PhenoGen Ncoa6 PhenoGen
UniProt A0A8I6AHU2_RAT UniProtKB/TrEMBL
  A0A8I6ARE2 ENTREZGENE, UniProtKB/TrEMBL
  G3V8C9 ENTREZGENE, UniProtKB/TrEMBL
  NCOA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JIH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ncoa6  nuclear receptor coactivator 6      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ncoa6  nuclear receptor coactivator 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a LXXLL motif 633379
gene_protein 2063 amino acid residues 633379