Bnip3 (BCL2 interacting protein 3) - Rat Genome Database

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Gene: Bnip3 (BCL2 interacting protein 3) Rattus norvegicus
Analyze
Symbol: Bnip3
Name: BCL2 interacting protein 3
RGD ID: 620800
Description: Enables identical protein binding activity. Involved in several processes, including autophagic cell death; cardiac muscle cell apoptotic process; and central nervous system development. Located in cytoplasm; dendrite; and nucleoplasm. Used to study congestive heart failure. Biomarker of several diseases, including cerebrovascular disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; obesity; and retinal detachment. Orthologous to human BNIP3 (BCL2 interacting protein 3); PARTICIPATES IN hypoxia inducible factor pathway; intrinsic apoptotic pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product; BCL2/adenovirus E1B interacting protein 3; MGC93043
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bnip3-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81203,137,778 - 203,154,962 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1203,137,778 - 203,154,962 (-)EnsemblGRCr8
mRatBN7.21193,708,164 - 193,725,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1202,078,679 - 202,095,736 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01209,213,763 - 209,230,820 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01201,887,245 - 201,904,303 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,248,098 - 211,265,282 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)Ensemblrn6Rnor6.0
Rnor_5.01218,174,697 - 218,191,883 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41198,683,009 - 198,700,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1191,399,941 - 191,417,104 (-)NCBICelera
RGSC_v3.11198,833,000 - 198,850,067 (-)NCBI
Cytogenetic Map1q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
bafilomycin A1  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
cannabidiol  (EXP)
capivasertib  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
concanamycin A  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (EXP)
drometrizole  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gefitinib  (ISO)
genistein  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
iohexol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
lapatinib  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
microcystin-LR  (ISO)
Mitotane  (EXP)
monensin A  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (EXP)
omeprazole  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paeoniflorin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (ISO)
Pf-06840003  (ISO)
pirinixic acid  (EXP,ISO)
poly(guanylic acid)  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
propofol  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
quinolone  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rotenone  (EXP,ISO)
roxadustat  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium lactate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraethylenepentamine  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
water  (ISO)
zinc acetate  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
autophagic cell death  (IMP)
brown fat cell differentiation  (ISO)
cardiac muscle cell apoptotic process  (IMP)
cellular response to cobalt ion  (IEA,ISO)
cellular response to hydrogen peroxide  (IEP,IMP)
cellular response to hypoxia  (IEA,IEP,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cerebral cortex development  (IEP)
defense response to virus  (IEA,ISO,ISS)
granzyme-mediated programmed cell death signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to hypoxia  (IEA,ISO)
mitochondrial fragmentation involved in apoptotic process  (IEA,ISO)
mitochondrial outer membrane permeabilization  (IBA,IEA,ISO)
mitochondrial protein catabolic process  (IEA,ISO)
mitophagy  (IEA,ISO)
negative regulation of membrane potential  (IEA,ISO,ISS)
negative regulation of mitochondrial fusion  (IEA,ISO)
negative regulation of mitochondrial membrane permeability involved in apoptotic process  (IMP)
negative regulation of mitochondrial membrane potential  (IMP)
negative regulation of programmed cell death  (ISO)
neuron apoptotic process  (IDA)
oligodendrocyte differentiation  (IEP)
positive regulation of apoptotic process  (IEA,IMP,ISO,ISS)
positive regulation of autophagy of mitochondrion  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cellular process  (IMP)
positive regulation of macroautophagy  (ISO)
positive regulation of mitochondrial calcium ion concentration  (IMP)
positive regulation of mitochondrial fission  (IEA,ISO)
positive regulation of programmed cell death  (IBA,IEA,ISO,ISS)
positive regulation of protein-containing complex disassembly  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO)
reactive oxygen species metabolic process  (IEA,ISO,ISS)
regulation of mitochondrial membrane permeability  (IEA,ISO,ISS)
response to axon injury  (IEP)
response to bacterium  (ISO)
response to hyperoxia  (IEP)
response to hypoxia  (IDA)
response to oxygen-glucose deprivation  (IEP)
reticulophagy  (IEA,ISO)
substrate localization to autophagosome  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway. Byun YJ, etal., Neurosci Lett. 2009 Sep 18;461(2):131-5. Epub 2009 Jun 17.
2. Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. Chaanine AH, etal., Circ Heart Fail. 2013 May;6(3):572-83. doi: 10.1161/CIRCHEARTFAILURE.112.000200. Epub 2013 Mar 18.
3. Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat. Cho B, etal., Mol Cells. 2012 Jun;33(6):605-10. doi: 10.1007/s10059-012-0051-0. Epub 2012 May 23.
4. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Dhingra R, etal., Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5537-44. doi: 10.1073/pnas.1414665111. Epub 2014 Dec 8.
5. MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. Diao H, etal., Biosci Biotechnol Biochem. 2017 Sep;81(9):1712-1720. doi: 10.1080/09168451.2017.1343118. Epub 2017 Jun 29.
6. Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease. Dong Y, etal., BMC Complement Altern Med. 2015 Mar 10;15:51. doi: 10.1186/s12906-015-0559-x.
7. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. Fedorova LV, etal., BMC Nephrol. 2013 Oct 4;14:209. doi: 10.1186/1471-2369-14-209.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Hamacher-Brady A, etal., Cell Death Differ. 2007 Jan;14(1):146-57. Epub 2006 Apr 28.
11. Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Ishihara M, etal., Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F495-509. doi: 10.1152/ajprenal.00642.2012. Epub 2013 May 22.
12. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
13. Autophagy signaling in skeletal muscle of infarcted rats. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
14. Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury. Jian B, etal., Mol Med. 2011 May-Jun;17(5-6):542-9. doi: 10.2119/molmed.2010.00195. Epub 2010 Dec 22.
15. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Kubasiak LA, etal., Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12825-30.
16. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
17. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H(2)O(2))-induced apoptosis through targeting the mitochondria apoptotic pathway. Li R, etal., PLoS One. 2012;7(9):e44907. doi: 10.1371/journal.pone.0044907. Epub 2012 Sep 18.
18. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
19. More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Lu MC, etal., Obesity (Silver Spring). 2007 Nov;15(11):2634-42.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure. Min JJ, etal., Sci Rep. 2014 Jul 3;4:5555. doi: 10.1038/srep05555.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells. Prabhakaran K, etal., Neuroscience. 2007 Nov 30;150(1):159-67. Epub 2007 Jul 29.
25. Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Regula KM, etal., Circ Res 2002 Aug 9;91(3):226-31.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Localization and developmental ontogeny of the pro-apoptotic Bnip3 mRNA in the postnatal rat cortex and hippocampus. Sandau US and Handa RJ, Brain Res. 2006 Jul 19;1100(1):55-63. Epub 2006 Jun 12.
29. Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus. Schmidt-Kastner R, etal., Brain Res. 2004 Mar 19;1001(1-2):133-42.
30. Hypoxia inducible factor 1alpha contributes to regulation of autophagy in retinal detachment. Shelby SJ, etal., Exp Eye Res. 2015 Aug;137:84-93. doi: 10.1016/j.exer.2015.06.016. Epub 2015 Jun 17.
31. Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade. Sowter HM, etal., J Pathol. 2003 Dec;201(4):573-80.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Gene expression microarray analysis of early oxygen-induced retinopathy in the rat. Tea M, etal., J Ocul Biol Dis Infor. 2009 Dec 12;2(4):190-201.
34. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
35. Inhibiting HIF-1alpha by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats. Wu C, etal., Biochem Biophys Res Commun. 2013 Aug 2;437(3):469-74. doi: 10.1016/j.bbrc.2013.06.107. Epub 2013 Jul 9.
36. Induction of neuronal mitophagy in acute spinal cord injury in rats. Yu D, etal., Neurotox Res. 2013 Nov;24(4):512-22. doi: 10.1007/s12640-013-9397-0. Epub 2013 Apr 30.
37. Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. Zamora R, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G822-30. Epub 2005 Jul 7.
38. The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. Zhang X, etal., PLoS One. 2014 Dec 1;9(12):e113642. doi: 10.1371/journal.pone.0113642. eCollection 2014.
39. BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. Zhang Z, etal., Stroke. 2007 May;38(5):1606-13. Epub 2007 Mar 22.
Additional References at PubMed
PMID:7954800   PMID:9396766   PMID:9973195   PMID:10381623   PMID:10891486   PMID:14651853   PMID:16189514   PMID:16291751   PMID:16344406   PMID:16464515   PMID:16954213   PMID:16987017  
PMID:17082476   PMID:17114649   PMID:17274962   PMID:18096822   PMID:18337831   PMID:18371312   PMID:18492766   PMID:18790835   PMID:19088195   PMID:19147804   PMID:19255257   PMID:19273585  
PMID:19593445   PMID:19737385   PMID:20025887   PMID:20436456   PMID:20668412   PMID:21122071   PMID:21415393   PMID:21437288   PMID:21575413   PMID:21890690   PMID:22044588   PMID:22292033  
PMID:22403878   PMID:23012479   PMID:23395931   PMID:23648705   PMID:23692407   PMID:23716698   PMID:25416956   PMID:25810259   PMID:26317696   PMID:26471219   PMID:27107012   PMID:27112557  
PMID:27472881   PMID:27886395   PMID:28838842   PMID:29538088   PMID:29566574   PMID:30173922   PMID:30851408   PMID:31320615   PMID:31321998   PMID:31657084   PMID:31707369   PMID:31993850  
PMID:35951252   PMID:36627546   PMID:37542244  


Genomics

Comparative Map Data
Bnip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81203,137,778 - 203,154,962 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1203,137,778 - 203,154,962 (-)EnsemblGRCr8
mRatBN7.21193,708,164 - 193,725,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1202,078,679 - 202,095,736 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01209,213,763 - 209,230,820 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01201,887,245 - 201,904,303 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,248,098 - 211,265,282 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)Ensemblrn6Rnor6.0
Rnor_5.01218,174,697 - 218,191,883 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41198,683,009 - 198,700,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1191,399,941 - 191,417,104 (-)NCBICelera
RGSC_v3.11198,833,000 - 198,850,067 (-)NCBI
Cytogenetic Map1q41NCBI
BNIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810131,967,684 - 131,981,923 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10131,966,461 - 131,981,984 (-)Ensemblhg38GRCh38
GRCh3710133,781,188 - 133,795,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610133,631,194 - 133,645,425 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410133,631,193 - 133,645,425NCBI
Celera10127,425,370 - 127,439,605 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10127,330,366 - 127,344,602 (-)NCBIHuRef
CHM1_110134,062,287 - 134,076,530 (-)NCBICHM1_1
T2T-CHM13v2.010132,907,935 - 132,922,186 (-)NCBIT2T-CHM13v2.0
Bnip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397138,492,565 - 138,511,235 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7138,492,565 - 138,511,248 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387138,890,836 - 138,909,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7138,890,836 - 138,909,519 (-)Ensemblmm10GRCm38
MGSCv377146,082,519 - 146,101,189 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367138,729,179 - 138,747,849 (-)NCBIMGSCv36mm8
Celera7138,707,907 - 138,726,495 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map782.95NCBI
Bnip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554779,621,812 - 9,638,099 (-)Ensembl
ChiLan1.0NW_0049554779,621,812 - 9,630,406 (-)NCBIChiLan1.0ChiLan1.0
BNIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28143,924,591 - 143,938,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110143,929,948 - 143,944,284 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010128,671,663 - 128,685,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110132,857,375 - 132,871,628 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10132,858,211 - 132,871,634 (-)EnsemblpanPan2panpan1.1
BNIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,037,681 - 40,050,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,038,643 - 40,049,797 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2840,097,449 - 40,110,338 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02840,678,012 - 40,690,914 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2840,676,814 - 40,689,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,162,663 - 40,175,507 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,150,654 - 40,163,548 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02840,549,677 - 40,562,589 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bnip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072137,077,703 - 7,111,927 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648618,448,494 - 18,455,927 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648618,449,371 - 18,460,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BNIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14140,362,127 - 140,371,907 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114140,362,123 - 140,371,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214152,194,909 - 152,204,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BNIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19124,570,958 - 124,586,002 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9124,568,695 - 124,585,980 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604886,009,563 - 86,024,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bnip3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473714,848,350 - 14,862,965 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473714,848,355 - 14,863,731 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bnip3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1262,913,006 - 62,930,228 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bnip3
87 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23028672

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:241
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000023477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
Bnip3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,763,896 - 48,764,118 (+)MAPPERmRatBN7.2
Rnor_6.0953,617,317 - 53,617,538NCBIRnor6.0
Rnor_5.0953,285,469 - 53,285,690UniSTSRnor5.0
Celera946,432,519 - 46,432,740UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 12 79 206 91 90 59 131 59 6 447 252 20 184 107 124 31 32 32

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY095482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO403082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC660101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023477   ⟹   ENSRNOP00000023477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1203,137,778 - 203,154,962 (-)Ensembl
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)Ensembl
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080041   ⟹   ENSRNOP00000071075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1203,138,711 - 203,154,962 (-)Ensembl
mRatBN7.2 Ensembl1193,709,097 - 193,725,359 (-)Ensembl
Rnor_6.0 Ensembl1211,251,501 - 211,265,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094035   ⟹   ENSRNOP00000096119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1203,139,814 - 203,154,962 (-)Ensembl
mRatBN7.2 Ensembl1193,709,273 - 193,725,359 (-)Ensembl
RefSeq Acc Id: NM_053420   ⟹   NP_445872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81203,137,778 - 203,154,962 (-)NCBI
mRatBN7.21193,708,164 - 193,725,348 (-)NCBI
Rnor_6.01211,248,098 - 211,265,282 (-)NCBI
Rnor_5.01218,174,697 - 218,191,883 (-)NCBI
RGSC_v3.41198,683,009 - 198,700,075 (-)RGD
Celera1191,399,941 - 191,417,104 (-)NCBI
Sequence:
RefSeq Acc Id: NP_445872   ⟸   NM_053420
- UniProtKB: Q9ET45 (UniProtKB/TrEMBL),   A6HX99 (UniProtKB/TrEMBL),   A6INV7 (UniProtKB/TrEMBL),   F7FHM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071075   ⟸   ENSRNOT00000080041
Ensembl Acc Id: ENSRNOP00000023477   ⟸   ENSRNOT00000023477
Ensembl Acc Id: ENSRNOP00000096119   ⟸   ENSRNOT00000094035

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ET45-F1-model_v2 AlphaFold Q9ET45 1-187 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690506
Promoter ID:EPDNEW_R1025
Type:initiation region
Name:Bnip3_1
Description:BCL2 interacting protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01211,265,252 - 211,265,312EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620800 AgrOrtholog
BioCyc Gene G2FUF-57103 BioCyc
Ensembl Genes ENSRNOG00000017243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023477 ENTREZGENE
  ENSRNOT00000023477.8 UniProtKB/TrEMBL
  ENSRNOT00000080041.3 UniProtKB/TrEMBL
  ENSRNOT00000094035.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.1020 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105707 IMAGE-MGC_LOAD
  IMAGE:7190121 IMAGE-MGC_LOAD
InterPro BNIP3 UniProtKB/TrEMBL
KEGG Report rno:84480 UniProtKB/TrEMBL
MGC_CLONE MGC:91405 IMAGE-MGC_LOAD
  MGC:93043 IMAGE-MGC_LOAD
NCBI Gene 84480 ENTREZGENE
PANTHER BCL2/ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3 UniProtKB/TrEMBL
  PTHR15186 UniProtKB/TrEMBL
Pfam BNIP3 UniProtKB/TrEMBL
PhenoGen Bnip3 PhenoGen
RatGTEx ENSRNOG00000017243 RatGTEx
UniProt A0A8I6AQ99_RAT UniProtKB/TrEMBL
  A6HX99 ENTREZGENE
  A6INV7 ENTREZGENE, UniProtKB/TrEMBL
  F7FHM5 ENTREZGENE, UniProtKB/TrEMBL
  M9VYP0_RAT UniProtKB/TrEMBL
  Q9ET45 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6HX99 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 Bnip3  BCL2 interacting protein 3  Bnip3  BCL2/adenovirus E1B interacting protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Bnip3  BCL2/adenovirus E1B interacting protein 3  Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3    BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product  Name updated 1299863 APPROVED
2002-08-07 Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression results in membrane insertion and initiation of a cell death pathway with features similar to necrosis  
gene_product member of the BH3-only subfamily of Bcl-2 family proteins