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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of BNIP3 mRNA

PMID:24386269
increases expressionISORGD:13509136480464CTDcobaltous chloride results in increased expression of BNIP3 mRNA

PMID:19320972, PMID:19376846, PMID:20105288, PMID:22269387
increases expressionISORGD:7338146480464CTDcobaltous chloride results in increased expression of BNIP3 mRNA, cobaltous chloride results in increased expression of BNIP3 protein

PMID:15375294, PMID:17169330, PMID:23684559
multiple interactionsISORGD:13509136480464CTDHIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA], peoniflorin inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA], tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA]

PMID:22269387, PMID:25100165
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.