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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bnip3increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of BNIP3 proteinPMID:33127495
Bnip3decreases expressionISOBNIP3 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of BNIP3 mRNAPMID:26472689
Bnip3increases expressionISOBNIP3 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of BNIP3 mRNA; Cadmium Chloride results in increased expression of BNIP3 proteinPMID:12760830 PMID:25596134 PMID:33127495
Bnip3multiple interactionsISOBNIP3 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein]; FOXO3 protein affects the reaction [Cadmium Chloride results in increased expression of BNIP3 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of BNIP3 protein]PMID:33127495
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