RGD Reference Report - Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus. - Rat Genome Database

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Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus.

Authors: Schmidt-Kastner, R  Aguirre-Chen, C  Kietzmann, T  Saul, I  Busto, R  Ginsberg, MD 
Citation: Schmidt-Kastner R, etal., Brain Res. 2004 Mar 19;1001(1-2):133-42.
RGD ID: 2314028
Pubmed: PMID:14972662   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2003.11.065   (Journal Full-text)

The 19 kD interacting protein 3, Nip3/BNIP3, is a pro-apoptotic member of the Bcl-2 family induced during hypoxia via the hypoxia-inducible factor (HIF) 1. BNIP3 has been linked to both apoptotic and necrotic cell death involving mitochondrial permeability transition. Since apoptotic and necrotic mechanisms may occur in brain ischemia, immunohistochemical changes of BNIP3 were studied at 1, 2, 3 and 7 days after transient global brain ischemia (12.5 min) in ventilated normothermic rats. In control brains, BNIP3-like immunoreactivity was moderately strong in neuronal processes or cytoplasm and absent in the nucleus. In the ischemia-vulnerable CA1 neurons, BNIP3-positive granules were seen in the nucleus at 1 and 2 days, and these neurons were damaged at 3 and 7 days. The resistant CA3 neurons showed nuclear BNIP3 labeling by 1 day and then returned to the normal state. BNIP3-positive granules did not overlap with the nucleolus. Constitutively expressed BNIP3 may participate in apoptotic and necrotic processes after brain ischemia. Nuclear location of BNIP3 after brain ischemia indicates a novel role for the regulation of cell survival in neurons or a general disturbance of the nuclear envelope.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia  ISOBnip3 (Rattus norvegicus)2314028; 2314028 RGD 
transient cerebral ischemia  IEP 2314028 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron apoptotic process involved_inIDA 2314028PMID:14972662UniProt 
response to hypoxia involved_inIDA 2314028PMID:14972662UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cytoplasm located_inIDA 2314028PMID:14972662UniProt 
dendrite located_inIDA 2314028PMID:14972662UniProt 
dendrite  IDA 2314028 RGD 
nucleoplasm located_inIDA 2314028PMID:14972662UniProt 
nucleoplasm  IDA 2314028 RGD 
nucleus located_inIDA 2314028PMID:14972662UniProt 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
intrinsic apoptotic pathway   ISOBnip3 (Rattus norvegicus)2314028; 2314028 RGD 
intrinsic apoptotic pathway   TAS 2314028 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Bnip3  (BCL2 interacting protein 3)

Genes (Mus musculus)
Bnip3  (BCL2/adenovirus E1B interacting protein 3)

Genes (Homo sapiens)
BNIP3  (BCL2 interacting protein 3)


Additional Information