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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13509136480464CTDBNIP3 protein affects the susceptibility to Paraquat

PMID:18056701
decreases expressionISORGD:13509136480464CTDParaquat results in decreased expression of BNIP3 mRNA

PMID:18836921
increases expressionISORGD:13509136480464CTDParaquat results in increased expression of BNIP3 mRNA, Paraquat results in increased expression of BNIP3 protein

PMID:18056701, PMID:18266926, PMID:23315990
increases expressionISORGD:7338146480464CTDParaquat results in increased expression of BNIP3 protein

PMID:18056701
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.