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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7338146480464CTDTetrachlorodibenzodioxin results in decreased expression of BNIP3 mRNA

PMID:15251184, PMID:15667827
increases expressionISORGD:7338146480464CTDTetrachlorodibenzodioxin results in increased expression of BNIP3 mRNA

PMID:21041162
multiple interactionsISORGD:7338146480464CTD[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BNIP3 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BNIP3 mRNA

PMID:15251184, PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.