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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects splicingISORGD:7338146480464CTDEthanol affects the splicing of BNIP3 mRNA

PMID:30319688
decreases expressionISORGD:13509136480464CTDEthanol results in decreased expression of BNIP3 mRNA

PMID:28986285
increases expressionISORGD:7338146480464CTDEthanol results in increased expression of BNIP3 mRNA, Ethanol results in increased expression of BNIP3 protein

PMID:24095927, PMID:30319688
multiple interactionsISORGD:13509136480464CTD[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BNIP3 mRNA

PMID:29432896
multiple interactionsISORGD:7338146480464CTDDactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein], FOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of BNIP3 mRNA]

PMID:24095927
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.