Pecam1 (platelet and endothelial cell adhesion molecule 1) - Rat Genome Database

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Gene: Pecam1 (platelet and endothelial cell adhesion molecule 1) Rattus norvegicus
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Symbol: Pecam1
Name: platelet and endothelial cell adhesion molecule 1
RGD ID: 61927
Description: Enables protein phosphatase binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; cellular response to type II interferon; and negative regulation of actin filament polymerization. Located in cell surface and ruffle. Used to study pulmonary hypertension. Biomarker of bacterial pneumonia; orchitis; and osteoarthritis. Human ortholog(s) of this gene implicated in coronary artery disease; coronary stenosis; myocardial infarction; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1); PARTICIPATES IN malaria pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2-acetamidofluorene; 5-azacytidine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD31; MGC124998; Pecam; PECAM-1; platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,090,263 - 92,152,002 (-)NCBIGRCr8
mRatBN7.21091,590,521 - 91,652,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,645,826 - 96,707,375 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,108,988 - 96,170,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,513,174 - 91,573,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,850,971 - 94,913,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01094,598,951 - 94,660,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,056,220 - 96,057,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,260,186 - 90,318,290 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (IDA)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
babesiosis  (ISO)
bacterial pneumonia  (IEP)
Bone Fractures  (ISO)
Brain Injuries  (IDA)
Breast Neoplasms  (ISO)
chronic myeloid leukemia  (ISO)
chronic venous insufficiency  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
common variable immunodeficiency  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Endotoxemia  (ISO)
eosinophilic esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Radiation Injuries  (IEP)
glioblastoma  (ISO)
graft-versus-host disease  (ISO)
hyperkalemic periodic paralysis  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IDA,IEP)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IMP)
Neovascularization, Pathologic  (ISO)
neurilemmoma  (ISO)
neuroblastoma  (ISO)
Ocular Neovascularization  (ISO)
Optic Nerve Injuries  (IEP)
oral squamous cell carcinoma  (ISO)
orchitis  (IEP)
osteoarthritis  (IEP)
ovarian cancer  (ISO)
Penetrating Wounds  (ISO)
periodontitis  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
polycystic ovary syndrome  (ISO)
polymyalgia rheumatica  (ISO)
Preeclamptic Toxemia  (ISO)
psoriatic arthritis  (ISO)
pterygium  (ISO)
pulmonary hypertension  (IDA)
Reperfusion Injury  (IEP,IMP,ISO)
sarcoma  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
spinal muscular atrophy  (ISO)
systemic scleroderma  (ISO)
tauopathy  (ISO)
thrombocytopenia  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
Vascular System Injuries  (IDA)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
carbon monoxide  (EXP)
carrageenan  (EXP)
CGP 52608  (ISO)
chalcones  (EXP)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cobalt dichloride  (EXP,ISO)
cordycepin  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
D-glucose  (ISO)
demethoxycurcumin  (EXP)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furosemide  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
glucose  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
isorhamnetin  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
metformin  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
microcystin-LR  (ISO)
monocrotaline  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
nicotinic acid  (ISO)
Nonylphenol  (ISO)
NSC 23766  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
probucol  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sorafenib  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
bicellular tight junction assembly  (IEA,ISO)
cell adhesion  (ISO)
cell surface receptor signaling pathway  (IBA,IEA)
cell-cell adhesion  (ISO)
cell-cell adhesion via plasma-membrane adhesion molecules  (IBA,IEA,ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to type II interferon  (IEP)
diapedesis  (IEA,ISO)
endothelial cell migration  (ISO)
endothelial cell morphogenesis  (ISO)
endothelial cell-matrix adhesion  (ISO)
establishment of endothelial barrier  (IEA,ISO)
glomerular endothelium development  (IEA,ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA,ISO)
immune response  (IBA)
leukocyte cell-cell adhesion  (IEA,ISO)
monocyte extravasation  (IEA,ISO)
negative regulation of actin filament polymerization  (IDA)
negative regulation of GTPase activity  (IDA)
negative regulation of peptidyl-tyrosine phosphorylation  (IDA)
neutrophil extravasation  (IEA,ISO)
phagocytosis  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cellular extravasation  (IMP)
positive regulation of leukocyte migration  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of protein localization to cell-cell junction  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell migration  (ISO)
Rho protein signal transduction  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Asano Y, etal., Am J Pathol. 2010 Apr;176(4):1983-98. doi: 10.2353/ajpath.2010.090593. Epub 2010 Mar 12.
2. Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy. Baelde HJ, etal., Am J Kidney Dis. 2004 Apr;43(4):636-50.
3. Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis. Blankenberg FG, etal., J Nucl Med. 2011 Oct;52(10):1630-7. Epub 2011 Sep 2.
4. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. Bogen S, etal., J Exp Med. 1994 Mar 1;179(3):1059-64.
5. Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Breen DM, etal., Atherosclerosis. 2012 Jun;222(2):375-81. Epub 2012 Mar 27.
6. Intestinal lymph-borne factors induce lung release of inflammatory mediators and expression of adhesion molecules after an intestinal ischemic insult. Breithaupt-Faloppa AC, etal., J Surg Res. 2012 Jul;176(1):195-201. Epub 2011 Jul 28.
7. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Brudecki L, etal., Infect Immun. 2012 Jun;80(6):2026-34. Epub 2012 Mar 26.
8. Radiation-induced damage in different segments of the rat intestine after external beam irradiation of the liver. Cameron S, etal., Exp Mol Pathol. 2012 Apr;92(2):243-58. Epub 2011 Dec 29.
9. Apocynin Attenuates Lipopolysaccharide-Induced Lung Injury in an Isolated and Perfused Rat Lung Model. Chian CF, etal., Shock. 2012 May 15.
10. PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells. Couty JP, etal., J Neurochem. 2007 Oct;103(2):793-801. Epub 2007 Jul 27.
11. Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas. de Vries M, etal., Virchows Arch. 2012 Jun;460(6):629-36. Epub 2012 May 4.
12. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Dhanjal TS, etal., Blood. 2007 May 15;109(10):4237-44. Epub 2007 Jan 18.
13. A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies. Elrayess MA, etal., Atherosclerosis. 2003 May;168(1):131-8.
14. R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events. Elrayess MA, etal., Atherosclerosis. 2004 Nov;177(1):127-35.
15. [PECAM-1 and E-selectin expression in vulnerable plague and their relationships to myocardial Leu125Val polymorphism of PECAM-1 and Ser128Arg polymorphism of E-selectin in patients with acute coronary syndrome]. Fang F, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Dec;39(12):1110-6.
16. Synovial biomarkers in psoriatic arthritis. Fiocco U, etal., J Rheumatol Suppl. 2012 Jul;89:61-4.
17. Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis. Gao HK, etal., Hepatobiliary Pancreat Dis Int. 2003 Aug;2(3):463-6.
18. Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis. Gao HK, etal., World J Gastroenterol. 2005 Feb 7;11(5):661-4.
19. No evidence for the CD31 C/G gene polymorphism as an independent risk factor of coronary heart disease. Gardemann A, etal., Thromb Haemost. 2000 Apr;83(4):629.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium. Gaudreault N, etal., Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):264-72. Epub 2011 Nov 3.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade. Gompels LL, etal., Arthritis Res Ther. 2011;13(5):R161. Epub 2011 Oct 7.
24. Atheroprotective effect of CD31 receptor globulin through enrichment of circulating regulatory T-cells. Groyer E, etal., J Am Coll Cardiol. 2007 Jul 24;50(4):344-50. Epub 2007 Jul 6.
25. Expression of cell adhesion molecules, chemokines and chemokine receptors involved in leukocyte traffic in rats undergoing autoimmune orchitis. Guazzone VA, etal., Reproduction. 2012 May;143(5):651-62. Epub 2012 Feb 20.
26. Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size in a rat model of ischemia-reperfusion injury. Gumina RJ, etal., Circulation. 1996 Dec 15;94(12):3327-33.
27. Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus. Hebeda CB, etal., J Ethnopharmacol. 2011 May 17;135(2):261-9. doi: 10.1016/j.jep.2011.02.033. Epub 2011 Mar 15.
28. Parstatin suppresses ocular neovascularization and inflammation. Huang H, etal., Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5825-32. doi: 10.1167/iovs.10-5576. Epub 2010 Jun 10.
29. Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell chronic lymphocytic leukemia. Ibrahim S, etal., Cancer. 2003 Apr 15;97(8):1914-9.
30. Erythropoietin, but not asialoerythropoietin or carbamyl-erythropoietin, attenuates monocrotaline-induced pulmonary hypertension in rats. Ikarashi N, etal., Clin Exp Hypertens. 2012;34(8):575-81. doi: 10.3109/10641963.2012.681728. Epub 2012 May 4.
31. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Jaworski T, etal., Am J Pathol. 2011 Oct;179(4):2001-15. Epub 2011 Aug 10.
32. Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. Jhanji V, etal., Br J Ophthalmol. 2011 Sep;95(9):1309-15. Epub 2011 Jun 30.
33. Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study. Jiang JF, etal., Lancet Infect Dis. 2015 Feb;15(2):196-203. doi: 10.1016/S1473-3099(14)71046-1. Epub 2014 Dec 22.
34. Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice. Jimenez-Andrade JM and Mantyh PW, Arthritis Res Ther. 2012 May 1;14(3):R101.
35. Characterization of negatively charged phospholipids and cell origin of microparticles in women with gestational vascular complications. Katzenell S, etal., Thromb Res. 2012 Apr 23.
36. [Estimation of level of soluble form PECAM-1, ICAM-2 and TNF-alpha, IL-18 in serum patients with chronic myelogenic leukemia]. Kiersnowska-Rogowska B, etal., Przegl Lek. 2005;62(8):772-4.
37. Epigallocatechin gallate suppresses peritoneal fibrosis in mice. Kitamura M, etal., Chem Biol Interact. 2012 Jan 5;195(1):95-104. doi: 10.1016/j.cbi.2011.11.002. Epub 2011 Nov 15.
38. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
39. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia. Kroll H, etal., Blood. 2000 Aug 15;96(4):1409-14.
40. Platelet endothelial cell adhesion molecule-1 gene 125C/G polymorphism is associated with deep vein thrombosis. Li G, etal., Mol Med Rep. 2015 Aug;12(2):2203-10. doi: 10.3892/mmr.2015.3586. Epub 2015 Apr 1.
41. Diabetic impairment of C-kit bone marrow stem cells involves the disorders of inflammatory factors, cell adhesion and extracellular matrix molecules. Li TS, etal., PLoS One. 2011;6(10):e25543. Epub 2011 Oct 3.
42. Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily. Listi F, etal., Eur J Immunogenet. 2004 Aug;31(4):175-8.
43. ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration. Liu G, etal., Blood. 2012 Jul 17.
44. Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats. Liu T, etal., J Sex Med. 2011 Oct;8(10):2761-72. doi: 10.1111/j.1743-6109.2011.02421.x.
45. [Role of endothelial progenitor cells in optic nerve injury of rats]. Liu YM, etal., Zhonghua Yan Ke Za Zhi. 2011 Dec;47(12):1089-95.
46. Angiogenesis in the pathogenesis of pterygium. Livezeanu C, etal., Rom J Morphol Embryol. 2011;52(3):837-44.
47. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
48. Acetylcholinesterase inhibitors attenuate angiogenesis. Miyazaki R, etal., Clin Sci (Lond). 2012 Aug 1;123(4):241-9.
49. Lymphangiogenesis is induced during development of periodontal disease. Mkonyi LE, etal., J Dent Res. 2012 Jan;91(1):71-7. Epub 2011 Oct 6.
50. Heamostatic and genetic predisposing factors for stroke in children with sickle cell anemia. Mourad H, etal., Egypt J Immunol. 2008;15(1):25-37.
51. Calpain activity is essential in skin wound healing and contributes to scar formation. Nassar D, etal., PLoS One. 2012;7(5):e37084. Epub 2012 May 16.
52. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
53. Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes. Neubauer K, etal., BMC Physiol. 2008 May 8;8:9.
54. Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with Autism Spectrum Disorder. Onore CE, etal., Biol Psychiatry. 2012 Jun 19.
55. Naive CD4+ T cells and recent thymic emigrants in common variable immunodeficiency. Oraei M, etal., J Investig Allergol Clin Immunol. 2012;22(3):160-7.
56. Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction. Pepene CE Gynecol Endocrinol. 2012 May;28(5):370-4. Epub 2012 Mar 29.
57. Angiogenic remodeling in pediatric eosinophilic esophagitis is associated with increased levels of VEGFA, angiogenin, IL-8 and activation of the TNF-alpha-NFkappaB pathway. Persad R, etal., J Pediatr Gastroenterol Nutr. 2012 Feb 10.
58. Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Pickarski M, etal., BMC Musculoskelet Disord. 2011 Aug 24;12:197.
59. Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. Pinter E, etal., Am J Pathol. 1999 May;154(5):1367-79.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. Imbalance between endothelial injury and repair in patients with polymyalgia rheumatica: improvement with corticosteroid treatment. Pirro M, etal., J Intern Med. 2011 Dec 30. doi: 10.1111/j.1365-2796.2011.02510.x.
62. EVI1 targets platelet endothelial cell adhesion molecule and up-regulates its expression in chronic myeloid leukemia. Pradhan AK and Chakraborty S, Leuk Lymphoma. 2014 Apr;55(4):954-6. doi: 10.3109/10428194.2013.815350. Epub 2013 Jul 24.
63. Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine. Prasad S, etal., Clin Cancer Res. 2012 Jul 25.
64. PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. Privratsky JR, etal., Life Sci. 2012 Jan 30;90(5-6):177-84. Epub 2011 Nov 18.
65. Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma. Pullen NA, etal., J Neurooncol. 2012 Feb;106(3):461-71. Epub 2011 Aug 21.
66. Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. Qu Y, etal., Cancer Gene Ther. 2011 Sep;18(9):663-73. doi: 10.1038/cgt.2011.37. Epub 2011 Jul 15.
67. Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis. Rautou PE, etal., Gastroenterology. 2012 Jul;143(1):166-176.e6. Epub 2012 Mar 30.
68. GOA pipeline RGD automated data pipeline
69. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
70. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
71. Passive exercise using whole-body periodic acceleration enhances blood supply to ischemic hindlimb. Rokutanda T, etal., Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2872-80. Epub 2011 Sep 22.
72. The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). Sagawa K, etal., J Biol Chem. 1997 Dec 5;272(49):31086-91.
73. Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). Sagawa K, etal., J Biol Chem. 1997 May 16;272(20):13412-8.
74. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese. Sasaoka T, etal., Ann N Y Acad Sci. 2001 Dec;947:259-69; discussion 269-70.
75. Acceleration of cutaneous healing by electrical stimulation: degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study. Sebastian A, etal., Wound Repair Regen. 2011 Nov;19(6):693-708. doi: 10.1111/j.1524-475X.2011.00736.x. Epub 2011 Oct 19.
76. Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis. Shalhoub J, etal., Stroke. 2011 Dec;42(12):3634-6. Epub 2011 Sep 29.
77. Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung. Shimoyama T, etal., Med Sci Monit. 2006 Feb;12(2):BR51-6. Epub 2006 Jan 26.
78. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Singhal J, etal., Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. Epub 2011 Dec 15.
79. Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy. Somers E, etal., Neuromuscul Disord. 2012 May;22(5):435-42. Epub 2011 Dec 7.
80. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
81. Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model. Sun CK, etal., J Transl Med. 2011 Jul 22;9:118.
82. Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. Sun Z, etal., J Surg Res. 2002 Jun 15;105(2):220-33.
83. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
84. Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1. Tada Y, etal., Arthritis Rheum. 2003 Nov;48(11):3280-90.
85. Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial pneumonia in mice and rats. Tasaka S, etal., Am J Respir Crit Care Med 2003 Jan 15;167(2):164-70.
86. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
87. Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. Thompson RD, etal., J Immunol. 2000 Jul 1;165(1):426-34.
88. Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype. Tisato V, etal., PLoS One. 2012;7(6):e39543. Epub 2012 Jun 21.
89. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Vaporciyan AA, etal., Science. 1993 Dec 3;262(5139):1580-2.
90. Effects of atorvastatin in the regulation of circulating EPCs and angiogenesis in traumatic brain injury in rats. Wang B, etal., J Neurol Sci. 2012 Aug 15;319(1-2):117-23. Epub 2012 Jun 2.
91. Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. Wang XX, etal., Plast Reconstr Surg. 2011 Aug;128(2):395-405.
92. The homozygous combination of Leu125Val and Ser563Asn polymorphisms in the PECAM1 (CD31) gene is associated with early severe coronary heart disease. Wenzel K, etal., Hum Mutat. 1999 Dec;14(6):545.
93. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Yadav VR, etal., Int J Cancer. 2012 May 1;130(9):2176-84. doi: 10.1002/ijc.26251. Epub 2011 Sep 12.
94. Comparison of the therapeutic effects of extracts from Spirulina platensis and amnion membrane on inflammation-associated corneal neovascularization. Yang LL, etal., Int J Ophthalmol. 2012;5(1):32-7. Epub 2012 Feb 18.
95. Huanglian-Jie-Du-Tang extract protects against chronic brain injury after focal cerebral ischemia via hypoxia-inducible-factor-1alpha-regulated vascular endothelial growth factor signaling in mice. Ye Y, etal., Biol Pharm Bull. 2012;35(3):355-61.
96. Platelets are associated with xenograft tumor growth and the clinical malignancy of ovarian cancer through an angiogenesis-dependent mechanism. Yuan L and Liu X, Mol Med Rep. 2015 Apr;11(4):2449-58. doi: 10.3892/mmr.2014.3082. Epub 2014 Dec 11.
Additional References at PubMed
PMID:7589563   PMID:9290466   PMID:10878616   PMID:11078691   PMID:11254359   PMID:12110892   PMID:12477932   PMID:12736726   PMID:12890700   PMID:15489334   PMID:15572031   PMID:15985432  
PMID:16251442   PMID:16455951   PMID:16691571   PMID:17464107   PMID:17563397   PMID:17580308   PMID:17935476   PMID:18332105   PMID:18948084   PMID:19299737   PMID:19342684   PMID:20458337  
PMID:20473743   PMID:20620994   PMID:20724702   PMID:21464233   PMID:21564091   PMID:21708977   PMID:22266279   PMID:23395097   PMID:24009720   PMID:24588994   PMID:26607202   PMID:26702061  
PMID:26706435   PMID:27958302   PMID:31628816   PMID:32437020   PMID:38338969  


Genomics

Comparative Map Data
Pecam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,090,263 - 92,152,002 (-)NCBIGRCr8
mRatBN7.21091,590,521 - 91,652,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,645,826 - 96,707,375 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,108,988 - 96,170,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,513,174 - 91,573,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,850,971 - 94,913,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01094,598,951 - 94,660,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,056,220 - 96,057,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,260,186 - 90,318,290 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
PECAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,319,415 - 64,390,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,319,415 - 64,413,776 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,396,775 - 62,404,856 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,753,595 - 59,817,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,754,144 - 59,817,723NCBI
Celera1756,788,107 - 56,856,790 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,766,219 - 57,837,658 (-)NCBIHuRef
CHM1_11762,461,123 - 62,469,204 (-)NCBICHM1_1
T2T-CHM13v2.01765,189,155 - 65,283,610 (-)NCBIT2T-CHM13v2.0
Pecam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,545,039 - 106,606,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,545,043 - 106,641,454 (-)EnsemblGRCm39 Ensembl
GRCm3811106,654,213 - 106,715,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,654,217 - 106,750,628 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,515,532 - 106,576,595 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,470,308 - 106,531,371 (-)NCBIMGSCv36mm8
Celera11118,385,876 - 118,446,185 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1169.92NCBI
Pecam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,478,492 - 7,531,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,448,584 - 7,531,860 (+)NCBIChiLan1.0ChiLan1.0
PECAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,509,619 - 80,618,517 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,327,260 - 85,436,138 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,417,134 - 58,526,409 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,511,784 - 63,601,241 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,511,784 - 63,579,067 (-)Ensemblpanpan1.1panPan2
PECAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,166,124 - 12,219,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl912,166,775 - 12,219,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,062,602 - 13,116,028 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,828,912 - 13,882,564 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,828,916 - 13,885,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,775,258 - 12,828,596 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,703,955 - 14,757,407 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,705,590 - 14,758,833 (+)NCBIUU_Cfam_GSD_1.0
Pecam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,247,718 - 14,321,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,873,182 - 4,937,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,873,459 - 4,919,787 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PECAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,649,044 - 14,723,293 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,667,643 - 14,723,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,661,621 - 14,717,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PECAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11656,863,763 - 56,947,479 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1656,880,934 - 56,950,999 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607727,456,525 - 27,565,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pecam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487033,293 - 122,536 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pecam1
564 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:585
Count of miRNA genes:259
Interacting mature miRNAs:307
Transcripts:ENSRNOT00000046815
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat

Markers in Region
RH127691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,590,681 - 91,590,865 (+)MAPPERmRatBN7.2
Rnor_6.01094,851,132 - 94,851,315NCBIRnor6.0
Rnor_5.01094,599,112 - 94,599,295UniSTSRnor5.0
RGSC_v3.41096,056,381 - 96,056,564UniSTSRGSC3.4
Celera1090,260,347 - 90,260,530UniSTS
RH 3.4 Map10987.4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000094323   ⟹   ENSRNOP00000083671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105483   ⟹   ENSRNOP00000086124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106375   ⟹   ENSRNOP00000091045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110556   ⟹   ENSRNOP00000093793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110646   ⟹   ENSRNOP00000088286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,522 - 91,652,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117408   ⟹   ENSRNOP00000082668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,613,895 - 91,635,758 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117538   ⟹   ENSRNOP00000088919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)Ensembl
RefSeq Acc Id: NM_031591   ⟹   NP_113779
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,151,839 (-)NCBI
mRatBN7.21091,590,521 - 91,652,116 (-)NCBI
Rnor_6.01094,850,971 - 94,913,202 (-)NCBI
Rnor_5.01094,598,951 - 94,660,385 (-)NCBI
RGSC_v3.41096,056,220 - 96,057,232 (-)RGD
Celera1090,260,186 - 90,318,290 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085774   ⟹   XP_038941702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085775   ⟹   XP_038941703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085776   ⟹   XP_038941704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085777   ⟹   XP_038941705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085778   ⟹   XP_038941706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,151,942 (-)NCBI
mRatBN7.21091,590,521 - 91,652,220 (-)NCBI
RefSeq Acc Id: XM_039085779   ⟹   XP_038941707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085780   ⟹   XP_038941708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
RefSeq Acc Id: XM_039085781   ⟹   XP_038941709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,090,263 - 92,152,002 (-)NCBI
mRatBN7.21091,590,521 - 91,652,279 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113779   ⟸   NM_031591
- Peptide Label: precursor
- UniProtKB: P97635 (UniProtKB/Swiss-Prot),   Q3SWT0 (UniProtKB/Swiss-Prot),   A0A8I5ZVC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038941709   ⟸   XM_039085781
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941707   ⟸   XM_039085779
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941704   ⟸   XM_039085776
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ADR9 (UniProtKB/TrEMBL),   A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941708   ⟸   XM_039085780
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A674 (UniProtKB/TrEMBL),   A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941705   ⟸   XM_039085777
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A5G8 (UniProtKB/TrEMBL),   A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941703   ⟸   XM_039085775
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA0 (UniProtKB/TrEMBL),   A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941702   ⟸   XM_039085774
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GHL3 (UniProtKB/TrEMBL),   A0A8I5ZXI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941706   ⟸   XM_039085778
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZVC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082668   ⟸   ENSRNOT00000117408
RefSeq Acc Id: ENSRNOP00000086124   ⟸   ENSRNOT00000105483
RefSeq Acc Id: ENSRNOP00000083671   ⟸   ENSRNOT00000094323
RefSeq Acc Id: ENSRNOP00000088919   ⟸   ENSRNOT00000117538
RefSeq Acc Id: ENSRNOP00000093793   ⟸   ENSRNOT00000110556
RefSeq Acc Id: ENSRNOP00000088286   ⟸   ENSRNOT00000110646
RefSeq Acc Id: ENSRNOP00000091045   ⟸   ENSRNOT00000106375
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3SWT0-F1-model_v2 AlphaFold Q3SWT0 1-678 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61927 AgrOrtholog
BioCyc Gene G2FUF-22930 BioCyc
Ensembl Genes ENSRNOG00000066008 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000094323.1 UniProtKB/TrEMBL
  ENSRNOT00000105483.1 UniProtKB/TrEMBL
  ENSRNOT00000106375.1 UniProtKB/TrEMBL
  ENSRNOT00000110556.1 UniProtKB/TrEMBL
  ENSRNOT00000110646.1 UniProtKB/TrEMBL
  ENSRNOT00000117408 ENTREZGENE
  ENSRNOT00000117408.1 UniProtKB/TrEMBL
  ENSRNOT00000117538.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7368518 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29583 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124998 IMAGE-MGC_LOAD
NCBI Gene 29583 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLATELET ENDOTHELIAL CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pecam1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000066008 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC236488
UniProt A0A8I5ZVC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5G8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A674 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHL3 ENTREZGENE, UniProtKB/TrEMBL
  P97635 ENTREZGENE
  PECA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P97635 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Pecam1  platelet and endothelial cell adhesion molecule 1  Pecam1  platelet/endothelial cell adhesion molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pecam1  platelet/endothelial cell adhesion molecule 1  Pecam  platelet/endothelial cell adhesion molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pecam  platelet/endothelial cell adhesion molecule      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed constitutively on pulmonary arterial, capillary, and venular endothelium 724645
gene_process mediates neutrophil emigration induced by IgG immune complexes during bacterial pneumonia 724645
gene_product member of immunoglobulin (Ig) gene superfamily 724645