RGD Reference Report - Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. - Rat Genome Database

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Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis.

Authors: Wang, XX  Allen RJ, JR  Tutela, JP  Sailon, A  Allori, AC  Davidson, EH  Paek, GK  Saadeh, PB  McCarthy, JG  Warren, SM 
Citation: Wang XX, etal., Plast Reconstr Surg. 2011 Aug;128(2):395-405.
RGD ID: 6771211
Pubmed: PMID:21788831   (View Abstract at PubMed)
DOI: DOI:10.1097/PRS.0b013e31821e6e10   (Journal Full-text)

BACKGROUND: Although bone repair is a relatively efficient process, a significant portion of patients fail to heal their fractures. Because adequate blood supply is essential to osteogenesis, the authors hypothesize that augmenting neovascularization by increasing the number of circulating progenitor cells will improve bony healing. METHODS: Bilateral full-thickness defects were created in the parietal bones of C57 wild-type mice. Intraperitoneal AMD3100 (n = 33) or sterile saline (n = 33) was administered daily beginning on postoperative day 3 and continuing through day 18. Circulating progenitor cell number was quantified by fluorescence-activated cell sorting. Bone regeneration was assessed with micro-computed tomography. Immunofluorescent CD31 and osteocalcin staining was performed to assess for vascularity and osteoblast density. RESULTS: AMD3100 treatment increased circulating progenitor cell levels and significantly improved bone regeneration. Calvarial defects of AMD3100-treated mice demonstrated increased vascularity and osteoblast density. CONCLUSIONS: Improved bone regeneration in this model was associated with elevated circulating progenitor cell number and subsequently improved neovascularization and osteogenesis. These findings highlight the importance of circulating progenitor cells in bone healing and may provide a novel therapy for bone regeneration.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bone Fractures  ISOPecam1 (Mus musculus)6771211; 6771211 RGD 
Bone Fractures  IDA 6771211 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pecam1  (platelet and endothelial cell adhesion molecule 1)

Genes (Mus musculus)
Pecam1  (platelet/endothelial cell adhesion molecule 1)

Genes (Homo sapiens)
PECAM1  (platelet and endothelial cell adhesion molecule 1)


Additional Information