Pecam1 (platelet and endothelial cell adhesion molecule 1) - Rat Genome Database

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Gene: Pecam1 (platelet and endothelial cell adhesion molecule 1) Heterocephalus glaber
Analyze
Symbol: Pecam1
Name: platelet and endothelial cell adhesion molecule 1
RGD ID: 18920564
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein phosphatase binding (ortholog); INVOLVED IN angiogenesis (ortholog); bicellular tight junction assembly (ortholog); cell adhesion (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); atherosclerosis (ortholog); FOUND IN cell periphery (ortholog); cell surface (ortholog); cell-cell contact zone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet endothelial cell adhesion molecule
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487033,293 - 122,536 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
babesiosis  (ISO)
bacterial pneumonia  (ISO)
Bone Fractures  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
chronic myeloid leukemia  (ISO)
chronic venous insufficiency  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
common variable immunodeficiency  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Endotoxemia  (ISO)
eosinophilic esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Radiation Injuries  (ISO)
glioblastoma  (ISO)
graft-versus-host disease  (ISO)
hyperkalemic periodic paralysis  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
myeloid leukemia  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neovascularization, Pathologic  (ISO)
neurilemmoma  (ISO)
neuroblastoma  (ISO)
Ocular Neovascularization  (ISO)
Optic Nerve Injuries  (ISO)
oral squamous cell carcinoma  (ISO)
orchitis  (ISO)
osteoarthritis  (ISO)
ovarian cancer  (ISO)
Penetrating Wounds  (ISO)
periodontitis  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
polycystic ovary syndrome  (ISO)
polymyalgia rheumatica  (ISO)
Preeclamptic Toxemia  (ISO)
psoriatic arthritis  (ISO)
pterygium  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
sarcoma  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
spinal muscular atrophy  (ISO)
systemic scleroderma  (ISO)
tauopathy  (ISO)
thrombocytopenia  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
Vascular System Injuries  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
bicellular tight junction assembly  (ISO)
cell adhesion  (IEA,ISO)
cell surface receptor signaling pathway  (IEA)
cell-cell adhesion  (ISO)
cell-cell adhesion via plasma-membrane adhesion molecules  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to type II interferon  (ISO)
detection of mechanical stimulus  (ISO)
diapedesis  (ISO)
endothelial cell migration  (ISO)
endothelial cell morphogenesis  (ISO)
endothelial cell-matrix adhesion  (ISO)
establishment of endothelial barrier  (ISO)
glomerular endothelium development  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (ISO)
immune response  (IEA)
leukocyte cell-cell adhesion  (ISO)
monocyte extravasation  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil extravasation  (ISO)
phagocytosis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to cell-cell junction  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell migration  (ISO)
Rho protein signal transduction  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pecam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487033,293 - 122,536 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PECAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,319,415 - 64,390,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,319,415 - 64,413,776 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,396,775 - 62,404,856 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,753,595 - 59,817,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,754,144 - 59,817,723NCBI
Celera1756,788,107 - 56,856,790 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,766,219 - 57,837,658 (-)NCBIHuRef
CHM1_11762,461,123 - 62,469,204 (-)NCBICHM1_1
T2T-CHM13v2.01765,189,155 - 65,283,610 (-)NCBIT2T-CHM13v2.0
Pecam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,545,039 - 106,606,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,545,043 - 106,641,454 (-)EnsemblGRCm39 Ensembl
GRCm3811106,654,213 - 106,715,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,654,217 - 106,750,628 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,515,532 - 106,576,595 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,470,308 - 106,531,371 (-)NCBIMGSCv36mm8
Celera11118,385,876 - 118,446,185 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1169.92NCBI
Pecam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,090,263 - 92,152,002 (-)NCBIGRCr8
mRatBN7.21091,590,521 - 91,652,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,590,521 - 91,652,116 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,645,826 - 96,707,375 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,108,988 - 96,170,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,513,174 - 91,573,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,850,971 - 94,913,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01094,598,951 - 94,660,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,056,220 - 96,057,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,260,186 - 90,318,290 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Pecam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,478,492 - 7,531,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,448,584 - 7,531,860 (+)NCBIChiLan1.0ChiLan1.0
PECAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,509,619 - 80,618,517 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,327,260 - 85,436,138 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,417,134 - 58,526,409 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,511,784 - 63,601,241 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,511,784 - 63,579,067 (-)Ensemblpanpan1.1panPan2
PECAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,166,124 - 12,219,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl912,166,775 - 12,219,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,062,602 - 13,116,028 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,828,912 - 13,882,564 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,828,916 - 13,885,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,775,258 - 12,828,596 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,703,955 - 14,757,407 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,705,590 - 14,758,833 (+)NCBIUU_Cfam_GSD_1.0
Pecam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,247,718 - 14,321,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,873,182 - 4,937,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,873,459 - 4,919,787 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PECAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,649,044 - 14,723,293 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,667,643 - 14,723,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,661,621 - 14,717,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PECAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11656,863,763 - 56,947,479 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1656,880,934 - 56,950,999 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607727,456,525 - 27,565,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004870297   ⟹   XP_004870354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462487033,293 - 89,953 (-)NCBI
RefSeq Acc Id: XM_013067635   ⟹   XP_012923089
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462487033,293 - 122,536 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004870354 (Get FASTA)   NCBI Sequence Viewer  
  XP_012923089 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00100001750
GenBank Protein JAO02362 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012923089   ⟸   XM_013067635
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JFH6 (UniProtKB/TrEMBL),   G5BVF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004870354   ⟸   XM_004870297
- Peptide Label: isoform X2
- UniProtKB: A0AAX6Q8Z5 (UniProtKB/TrEMBL),   G5BVF5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00100001363 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00100001789 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_C17orf99 UniProtKB/TrEMBL
  Ig_Fc_receptor UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
NCBI Gene Pecam1 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  IMMUNOGLOBULIN FC RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Ig_C17orf99 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0P6JFH6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q8Z5 ENTREZGENE, UniProtKB/TrEMBL
  G5BVF5 ENTREZGENE, UniProtKB/TrEMBL