Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; negative regulation of inositol phosphate biosynthetic process; and positive regulation of large conductance calcium-activated potassium channel activity. Located in acrosomal vesicle; nucleoplasm; and sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1); PARTICIPATES IN eicosanoid signaling pathway; long term depression; INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 3,4-methylenedioxymethamphetamine; 4-hydroxy-TEMPO.
cAMP-dependent protein kinase catalytic subunit PRKX-like; cGk1; cGMP dependent protein kinase type 1; cGMP dependent protein kinase type1; cGMP-dependent protein kinase 1; LOC100912084; LOC365449; Pkgi; Prkg1_mapped; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type 1 (mapped); Protein kinase, cGMP-dependent, type I
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA more ...
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PRKG1 mRNA
[8-((4-chlorophenyl)thio)cyclic-3' and 5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
[bisphenol A co-treated with Fulvestrant] results in increased methylation of PRKG1 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRKG1 mRNA
[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3' and 5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]
[Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein and VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]
[Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein and VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]
Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA] and Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA more ...
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA more ...
[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3' and 5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PRKG1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PRKG1 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA
Resveratrol promotes the reaction [Vitamin K 3 results in increased oxidation of PRKG1 protein] and Resveratrol results in increased oxidation of and results in increased activity of PRKG1 protein
[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA
PRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CCN2 mRNA]] more ...
5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein] and Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein]
[Tadalafil co-treated with Thioacetamide] results in increased expression of PRKG1 protein and Tadalafil inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein]
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA] and testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA] and testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]
Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3' and 5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]
Nitric oxide modulation of agonist-evoked intracellular Ca2+ release in neurosecretory PC-12 cells: inhibition of phospholipase C activity via cyclic GMP-dependent protein kinase I.
Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats.
Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat.
Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric oxide in rat hippocampal nerve terminals.
Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis.
expressed at high levels in cerebellar Purkinje cells and human platelets, moderately in vascular smooth muscle cells, and at a lower levels in cardiac myocytes
lowers intracellular Ca2+, and inhibits vascular smooth muscle contraction, platelet activation and endothelial cell permeability, thereby opposing events leading to hypertension, thrombosis, and atherosclerosis
