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GENE - TERM ANNOTATION REPORT

RGD ID: 1587390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
Acc ID: DOID:14004
Term: thoracic aortic aneurysm
Definition: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Definition Source(s): MESH:D017545, http://en.wikipedia.org/wiki/Aortic_aneurysm, http://en.wikipedia.org/wiki/Thoracic_aortic_aneurysm
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:13224428554872ClinVarClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection

PMID:16646045, PMID:23910461, PMID:23953976, PMID:27442293, PMID:27879251, PMID:28492532
 ISORGD:13224428554872ClinVarClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection

PMID:23910461, PMID:28492532
 ISORGD:13224428554872ClinVarClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection

PMID:25741868, PMID:28492532
 ISORGD:13224428554872ClinVarClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection

PMID:28492532
 ISORGD:13224428554872ClinVarClinVar Annotator: match by term: Thoracic aortic aneurysms and aortic dissections

 
 ISSRGD:132244213592920MouseDOOMIM:132900 , OMIM:607086 , OMIM:607087 , OMIM:611788 , OMIM:613780 , OMIM:615436 , OMIM:617349

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.