RGD Gene Chemical Interaction Report

GENE - TERM ANNOTATION REPORT

RGD ID:	1587390
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Prkg1
Name:	protein kinase cGMP-dependent 1

Acc ID:	DOID:14004
Term:	thoracic aortic aneurysm
Definition:	An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Definition Source(s):	MESH:D017545, http://en.wikipedia.org/wiki/Aortic_aneurysm, http://en.wikipedia.org/wiki/Thoracic_aortic_aneurysm

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
	ISO	RGD:1322442	8554872	ClinVar	ClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection	PMID:16646045, PMID:23910461, PMID:23953976, PMID:27442293, PMID:27879251, PMID:28492532
	ISO	RGD:1322442	8554872	ClinVar	ClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection	PMID:23910461, PMID:28492532
	ISO	RGD:1322442	8554872	ClinVar	ClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection	PMID:25741868, PMID:28492532
	ISO	RGD:1322442	8554872	ClinVar	ClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissection	PMID:28492532
	ISO	RGD:1322442	8554872	ClinVar	ClinVar Annotator: match by term: Thoracic aortic aneurysms and aortic dissections
	ISS	RGD:1322442	13592920	MouseDO	OMIM:132900 , OMIM:607086 , OMIM:607087 , OMIM:611788 , OMIM:613780 , OMIM:615436 , OMIM:617349

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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