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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1587390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
Acc ID: CHEBI:77702
Term: S-nitroso-N-acetyl-D-penicillamine
Definition: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
Chemical ID: MESH:D026423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDS-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein

PMID:11799084
multiple interactionsEXP 6480464CTD[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:11799084
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.