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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1587390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDGlucose results in decreased expression of PRKG1 mRNA

PMID:17320767
multiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein], diphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein], Glucose results in decreased expression of and results in decreased activity of PRKG1 protein, manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of PRKG1 protein], Reactive Oxygen Species promotes the reaction [Glucose results in decreased expression of PRKG1 protein], tempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]

PMID:17320767
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.