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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1587390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
Acc ID: CHEBI:38725
Term: mevinphos
Definition: An organophosphate insecticide that has formula C7H13O6P.
Chemical ID: MESH:D008799
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkg1increases expressionEXP 6480464CTDMevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 proteinPMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397
Prkg1multiple interactionsEXP 6480464CTD1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]PMID:15617736 PMID:17150954 PMID:21390240
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