| 1307970 | Sync | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); neuromuscular junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 4,4'-sulfonyldiphenol | 5 | 146915715 | 146940547 | Rat | 86 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317471 | Sync | syncoilin | Acts upstream of or within intermediate filament-based process. Located in several cellular components, including Z disc; neuromuscular junction; and sarcolemma. Is expressed in tibialis anterior. Orthologous to human SYNC (sync pan>oilin, intermediate filament protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 129181066 | 129203175 | Mouse | 87 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346585 | SYNC | syncoilin, intermediate filament protein | This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex ( DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] | 1 | 32679906 | 32703593 | Human | 83 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8946623 | Sync | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); neuromuscular junction (ortholog) | NW_004955452 | 10975039 | 10984598 | Chinchilla | 12 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11863978 | SYNC | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intermediate filament (inferred) | 1 | 31973545 | 31996103 | Bonobo | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12348260 | SYNC | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intermediate filament (inferred) | 2 | 68625363 | 68638604 | Dog | 19 | symbol , old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12694650 | Sync | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intermediate filament (inferred) | NW_004936474 | 15611236 | 15631576 | Squirrel | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14237931 | SYNC | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intermediate filament (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 20 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18734067 | SYNC | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intermediate filament (inferred) | | | | Green Monkey | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18918010 | Sync | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 284431945 | sync | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626040520 | Sync | syncoilin, intermediate filament protein | INVOLVED IN intermediate filament-based process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); neuromuscular junction (ortholog) | | | | Black Rat | 12 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 285896556 | sync.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284801078 | sync.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1313848 | Cadm2 | cell adhesion molecule 2 | Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in axon. Predicted to be active in neuronal cell body membrane. Is expressed in bone; central nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 66452302 | 67417825 | Mouse | 83 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1315992 | Cadm3 | cell adhesion molecule 3 | Enables protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within protein localization. Located in cell-cell junction. Is active in paralle l fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 173161825 | 173195214 | Mouse | 92 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1305683 | Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding; mRNA 5'-UTR binding; poly(A) binding (ortholog); INVOLVED IN circadian rhythm; negative regulation of mRNA modification; positive regulation of translation; PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN glutamatergic synapse; neuronal cell body; postsynaptic density; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 8 | 98282358 | 98315412 | Rat | 200 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313857 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded p rotein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011] | 6 | 85607784 | 85643870 | Human | 221 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557624 | Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein | Enables poly(A) binding activity. Predicted to be involved in several processes, including cellular response to type II interferon; negative regulation of mRNA metabolic process; and regulation of translation. Located in cytoplasm. Part of histone pre-mRNA 3'end processing complex. Is expressed in s everal structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 88331417 | 88364645 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8767267 | Syncrip | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); circadian rhythm (ortholog); CRD-mediated mRNA stabilization (ortholog); PARTICIPATES IN spliceosome pathway; AS SOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); CRD-mediated mRNA stability complex (ortholog); cytoplasm (ortholog) | NW_004955411 | 13068078 | 13096936 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11898301 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); circadian rhythm (ortholog); CRD-mediated mRNA stabilization (ortholog); PARTICIPATES IN spliceosome pathway; AS SOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN CRD-mediated mRNA stability complex (ortholog); cytosol (ortholog); GAIT complex (ortholog) | 6 | 83491803 | 83527256 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12432494 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); circadian rhythm (ortholog); mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); cytosol (ortholog); GAIT complex (ortholog) | 12 | 45613947 | 45644879 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12545999 | Syncrip | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN circadian rhythm (ortholog); mRNA modification (ortholog); negative regulation of mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN glutamatergic synapse (ortholog); histone pre-mRNA 3'end processing complex (ortholog); neuronal cell body (ortholog) | NW_004936510 | 5643072 | 5672258 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13971068 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN circadian rhythm (ortholog); mRNA modification (ortholog); negative regulation of mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN glutamatergic synapse (ortholog); histone pre-mRNA 3'end processing complex (ortholog); neuronal cell body (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18676056 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN circadian rhythm (ortholog); mRNA modification (ortholog); negative regulation of mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN glutamatergic synapse (ortholog); histone pre-mRNA 3'end processing complex (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908742 | Syncrip | synaptotagmin binding cytoplasmic RNA interacting protein | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA 5'-UTR binding (ortholog); poly(A) binding (ortholog); INVOLVED IN cellular response to type II interferon (ortholog); circadian rhythm (ortholog); CRD-mediated mRNA stabilization (ortholog); PARTICIPATES IN spliceosome pathway; AS SOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); leukemia (ortholog); FOUND IN catalytic step 2 spliceosome (ortholog); CRD-mediated mRNA stability complex (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257315 | syncrip | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155257391 | syncrip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239007 | syncrip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16555866 | SYNCRIPP1 | SYNCRIP pseudogene 1 | | 20 | 6213597 | 6215339 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6486401 | Syncrip-ps1 | synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 1 | | 11 | 69383590 | 69384965 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6500498 | Syncrip-ps2 | synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 2 | | 8 | 98349672 | 98378405 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1615713 | Syna | syncytin a | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in th e gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 5 | 134586108 | 134605891 | Mouse | 46 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1310999 | Cadm1 | cell adhesion molecule 1 | ENCODES a protein that exhibits cell adhesion molecule binding; identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN liver development; negative regulation of ERBB4 signaling pathway; negative regulation of protein phosphorylation; ASSOCIATED WITH hepatocellular carcinoma ; lung adenocarcinoma; autistic disorder (ortholog); FOUND IN dendrite; postsynaptic density; axon (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 8 | 56744374 | 57075264 | Rat | 268 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1322220 | CADM1 | cell adhesion molecule 1 | Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomark er of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 115169236 | 115504415 | Human | 261 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1313847 | CADM2 | cell adhesion molecule 2 | This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] | 3 | 84958989 | 86074429 | Human | 83 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315991 | CADM3 | cell adhesion molecule 3 | The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provid ed by RefSeq, Oct 2016] | 1 | 159171615 | 159203313 | Human | 120 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312331 | CADM4 | cell adhesion molecule 4 | Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [p rovided by Alliance of Genome Resources, Jul 2025] | 19 | 43622368 | 43641984 | Human | 100 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 30309386 | Synb | syncytin b | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 14 | 69527827 | 69549857 | Mouse | 70 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1305678 | Cadm2 | cell adhesion molecule 2 | INVOLVED IN synaptic membrane adhesion; ASSOCIATED WITH autism spectrum disorder (ortholog); hepatocellular carcinoma (ortholog); malignant astrocytoma (ortholog); FOUND IN axon; GABA-ergic synapse; glutamatergic synapse; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrac hlorodibenzodioxine | 11 | 17994856 | 18971895 | Rat | 91 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1312332 | Cadm4 | cell adhesion molecule 4 | Enables enzyme binding activity and vascular endothelial growth factor receptor binding activity. Involved in several processes, including negative regulation of cellular response to growth factor stimulus; negative regulation of protein phosphorylation; and regulation of Rac protein signal transduc tion. Predicted to be located in cell leading edge. Predicted to be active in cell-cell contact zone. Is expressed in dentate gyrus subgranular zone; dorsal root ganglion; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human CADM4 (cell adhesion molecule 4). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 24181448 | 24203958 | Mouse | 118 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620862 | Sycn | syncollin | INVOLVED IN exocytosis (inferred); regulation of calcium ion-dependent exocytosis (inferred); FOUND IN cytoplasmic vesicle (inferred); secretory granule membrane (inferred); zymogen granule membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; ammoni um chloride | 1 | 92950761 | 92961077 | Rat | 37 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 733709 | Sycn | syncollin | Predicted to be involved in exocytosis. Predicted to be located in zymogen granule membrane. Orthologous to human SYCN (syncollin). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 28240310 | 28241635 | Mouse | 39 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604473 | SYCN | syncollin | Predicted to be involved in exocytosis. Predicted to be located in zymogen granule membrane. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 39202825 | 39204263 | Human | 36 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 8970269 | Sycn | syncollin | | NW_004955468 | 350601 | 352966 | Chinchilla | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 11743693 | SYCN | syncollin | | 19 | 36301867 | 36303720 | Bonobo | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 12105143 | SYCN | syncollin | INVOLVED IN exocytosis (inferred); FOUND IN cytoplasmic vesicle (inferred); secretory granule membrane (inferred); zymogen granule membrane (inferred) | 1 | 113987711 | 113989112 | Dog | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 12561753 | Sycn | syncollin | INVOLVED IN exocytosis (inferred); FOUND IN cytoplasmic vesicle (inferred); secretory granule membrane (inferred); zymogen granule membrane (inferred) | NW_004936661 | 2061281 | 2062451 | Squirrel | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 14058085 | SYCN | syncollin | INVOLVED IN exocytosis (inferred); FOUND IN cytoplasmic vesicle (inferred); secretory granule membrane (inferred); zymogen granule membrane (inferred) | | | | Pig | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 18795513 | SYCN | syncollin | | | | | Green Monkey | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 18935976 | Sycn | syncollin | INVOLVED IN exocytosis (inferred); FOUND IN secretory granule membrane (inferred) | | | | Naked Mole-Rat | 3 | name | gene, protein-coding, MODEL [RefSeq] |
| 20867448 | SYCN | syncollin | INVOLVED IN exocytosis (inferred); FOUND IN cytoplasmic vesicle (inferred); secretory granule membrane (inferred); zymogen granule membrane (inferred) | | | | Green Monkey | 5 | name | gene, protein-coding |
| 626085075 | Sycn | syncollin | | | | | Black Rat | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 626143193 | LOC116885917 | syncytin-A | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 626145799 | LOC116913338 | syncytin-B | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 12170546 | CAR1 | syncytin-Car1 | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a dog endogenous retrovirus provirus that has inactivating mutations in the gag and pol gene s. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 3 | 83844415 | 83845836 | Dog | 1 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 12484924 | Mar1 | syncytin-Mar1 | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | NW_004936519 | 6380706 | 6382478 | Squirrel | | name | gene, protein-coding, REVIEWED [RefSeq] |
| 12555933 | LOC101957892 | syncoilin-like | | NW_004936499 | 10690687 | 10696675 | Squirrel | | name | gene, pseudo, MODEL [RefSeq] |
| 18925437 | LOC101702234 | syncytin-1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18915638 | LOC101716068 | syncytin-2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18905706 | LOC101718515 | syncytin-2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18921138 | LOC101718778 | syncytin-2-like | FOUND IN membrane (inferred) | | | | Naked Mole-Rat | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 18936106 | LOC101719065 | syncytin-2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8902238 | LOC102006347 | syncytin-1-like | | NW_004955417 | 31573854 | 31588270 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 18379085 | LOC103224400 | syncytin-1-like | FOUND IN membrane (inferred) | | | | Green Monkey | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 18928442 | LOC110344745 | syncytin-1-like | FOUND IN membrane (inferred) | | | | Naked Mole-Rat | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 32732494 | LOC117975297 | syncytin-1-like | | 12 | 50655315 | 50656949 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 32726723 | LOC117979877 | syncytin-1-like | | 4 | 51277569 | 51279195 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 32728681 | LOC117980658 | syncytin-1-like | | 6 | 104046971 | 104048681 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 40919713 | LOC119871310 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40922329 | LOC119875590 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40913465 | LOC119876162 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40907555 | LOC119876221 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40917544 | LOC119878113 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40918293 | LOC119881201 | syncytin-1-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 40918657 | LOC119881605 | syncytin-1-like | INVOLVED IN labyrinthine layer blood vessel development (ortholog); myoblast fusion (ortholog); myoblast fusion involved in skeletal muscle regeneration (ortholog) | | | | Dog | 11 | name | gene, protein-coding, MODEL [RefSeq] |
| 125054149 | LOC120891589 | syncytin-1-like | | | | | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 151674422 | LOC124902201 | syncytin-A-like | | 9 | 88037468 | 88077900 | Human | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 329344943 | LOC129393343 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329346585 | LOC129393543 | syncytin-1-like | | | | | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 329344726 | LOC129393968 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329332659 | LOC129394604 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329345379 | LOC129394875 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329344948 | LOC129395235 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329346239 | LOC129395381 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329346054 | LOC129395442 | syncytin-1-like | | | | | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 329347132 | LOC129397453 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329345171 | LOC129397514 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 329330418 | LOC129398673 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 402527030 | LOC134728680 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 402526864 | LOC134728888 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 402528323 | LOC134730565 | syncytin-1-like | | | | | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 402526217 | LOC134730787 | syncytin-1-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 598132812 | LOC140709574 | syncytin-1-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 598131582 | LOC140710754 | syncytin-1-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 598134715 | LOC140711577 | syncytin-1-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 598133435 | LOC140712988 | syncytin-1-like | FOUND IN membrane (inferred) | | | | Green Monkey | 1 | name | gene, protein-coding, MODEL [RefSeq] |
| 598131988 | LOC140713272 | syncytin-1-like | | | | | Green Monkey | | name | gene, protein-coding, MODEL [RefSeq] |
| 598131645 | LOC140713513 | syncytin-1-like | | | | | Green Monkey | | name | gene, protein-coding, MODEL [RefSeq] |
| 1322221 | Cadm1 | cell adhesion molecule 1 | Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; dendrite; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including central nervous system; metanephros; peripheral nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 47441468 | 47773578 | Mouse | 315 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1346740 | ERVW-1 | endogenous retrovirus group W member 1, envelope | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This g ene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] | 7 | 92468380 | 92477946 | Human | 38 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606632 | ERVFRD-1 | endogenous retrovirus group FRD member 1, envelope | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012] | 6 | 11102489 | 11111725 | Human | 66 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 11972182 | ERVFRD-1 | endogenous retrovirus group FRD member 1, envelope | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 6 | 10940832 | 10950152 | Bonobo | 7 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 18595802 | ERVFRD-1 | endogenous retrovirus group FRD member 1, envelope | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | | | | Green Monkey | 7 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 11781290 | ERVW-1 | endogenous retrovirus group W member 1, envelope | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 7 | 84466326 | 84475866 | Bonobo | 3 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1614143 | Gm27174 | predicted gene 27174 | INTERACTS WITH bisphenol A (ortholog); trichloroethene (ortholog) | 14 | 69760100 | 69792776 | Mouse | 2 | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 39129649 | Gm27179 | predicted gene 27179 | INTERACTS WITH 2-hydroxypropanoic acid (ortholog); amphetamine (ortholog); ethylparaben (ortholog) | 14 | 69745042 | 69753064 | Mouse | 7 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 5132012 | ERVV-2 | endogenous retrovirus group V member 2, envelope | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015] | 19 | 53044740 | 53051680 | Human | 8 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 329330781 | LOC129397685 | uncharacterized LOC129397685 | | | | | Bonobo | | old_gene_name | gene, ncrna, MODEL [RefSeq] |
| 38643542 | TMEM150C-AS1 | TMEM150C antisense RNA 1 | | 4 | 82469005 | 82483341 | Human | | old_gene_name | gene, ncrna, MODEL [RefSeq] |
| 12209583 | LOC102154491 | natural cytotoxicity triggering receptor 3 ligand 1-like | INVOLVED IN myoblast fusion (ortholog); syncytium formation (ortholog); syncytium formation by plasma membrane fusion (ortholog) | X | 50664130 | 50669080 | Dog | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 14006705 | LOC110259374 | uncharacterized LOC110259374 | INVOLVED IN myoblast fusion (ortholog); syncytium formation (ortholog); syncytium formation by plasma membrane fusion (ortholog) | | | | Pig | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 1566115 | Synb | syncytin b | INVOLVED IN syncytium formation by plasma membrane fusion (inferred); FOUND IN plasma membrane (inferred); INTERACTS WITH bisphenol A; trichloroethene | 15 | 50989313 | 50996237 | Rat | 5 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 18904342 | LOC101709858 | syncoilin pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18902988 | LOC101714276 | syncoilin pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1563240 | Ervfrd-1 | endogenous retrovirus group FRD member 1, envelope | INVOLVED IN labyrinthine layer development (ortholog); myoblast fusion (ortholog); syncytium formation (ortholog); INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; bisphenol A | 12 | 27787680 | 27794732 | Rat | 71 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 40892551 | ERVFC1 | Endogenous retrovirus group FC1 Env polyprotein | INVOLVED IN syncytium formation by plasma membrane fusion (ortholog) | | | | Green Monkey | 1 | description | gene, protein-coding, MODEL [RefSeq] |
| 329347039 | LOC129395372 | endogenous retrovirus group FC1 Env polyprotein | INVOLVED IN syncytium formation by plasma membrane fusion (ortholog) | | | | Bonobo | 1 | description | gene, protein-coding, MODEL [RefSeq] |
| 16558647 | AC021106.1 | synaptotagmin binding, cytoplasmic RNA interacting protein (SYNCRIP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1346019 | TCL1B | TCL1 family AKT coactivator B | Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 95686426 | 95692628 | Human | 28 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1606066 | LERFS | lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting | INTERACTS WITH bisphenol A; formaldehyde; lipopolysaccharide | 9 | 62857856 | 62898087 | Human | 5 | name | gene, ncrna, VALIDATED [RefSeq] |
| 38647180 | ERVFC1 | endogenous retrovirus group FC1 Env polyprotein | INVOLVED IN syncytium formation by plasma membrane fusion; FOUND IN plasma membrane (inferred) | X | 97841746 | 97849381 | Human | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 1550521 | Ace2 | angiotensin converting enzyme 2 | Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brai n; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 162922338 | 162971414 | Mouse | 564 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1352999 | BYSL | bystin like | Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present . Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008] | 6 | 41908759 | 41933046 | Human | 137 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735831 | Ccng1 | cyclin G1 | Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; mitotic G2 DNA damage checkpoint signaling; and syncytium formation. Predicte d to be located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to human CCNG1 (cyclin G1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 40639379 | 40646044 | Mouse | 375 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731701 | Cd81 | CD81 antigen | Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of receptor clustering; and syncytium formati on by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 142606487 | 142621667 | Mouse | 299 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1345686 | CXCL8 | C-X-C motif chemokine ligand 8 | The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020] | 4 | 73740569 | 73743716 | Human | 1936 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343792 | ERVH48-1 | endogenous retrovirus group 48 member 1, envelope | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015] | 21 | 42916803 | 42925630 | Human | 22 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11769828 | ERVH48-1 | endogenous retrovirus group 48 member 1, envelope | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015] | 21 | 29230537 | 29238436 | Bonobo | 4 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 598134676 | ERVH48-1 | endogenous retrovirus group 48 member 1, envelope | INVOLVED IN syncytium formation (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 18646403 | ERVW-1 | endogenous retrovirus group W member 1 | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This ge ne is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. This gene contains mutations and is inactive in Old World monkeys. [provided by RefSeq, May 2015] | | | | Green Monkey | | description | gene, pseudo, INFERRED [RefSeq] |
| 62144 | Gcm1 | glial cells missing homolog 1 | Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nu cleus. Is expressed in several structures, including extraembryonic component; metanephros; pancreas; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 77959240 | 77972906 | Mouse | 135 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736925 | GJA1 | gap junction protein alpha 1 | This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap j unctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014] | 6 | 121435646 | 121449727 | Human | 1365 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605323 | HMCN1 | hemicentin 1 | This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchora ge of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008] | 1 | 185734391 | 186190949 | Human | 196 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1620109 | Il9 | interleukin 9 | Enables cytokine activity. Involved in positive regulation of interleukin-5 production. Acts upstream of or within several processes, including B cell activation; regulation of peptidyl-tyrosine phosphorylation; and regulation of receptor signaling pathway via JAK-STAT. Located in extracellular spac e. Is expressed in gut; liver; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and respiratory syncytial virus infectious disease. Orthologous to human IL9 (interleukin 9). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 56627090 | 56630070 | Mouse | 136 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354230 | INSL4 | insulin like 4 | INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008] | 9 | 5231419 | 5235304 | Human | 27 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1619105 | Izumo1 | izumo sperm-egg fusion 1 | Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and receptor ligand activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization and syncytium formation by plasma me mbrane fusion. Acts upstream of or within sperm-egg recognition. Located in acrosomal membrane and endoplasmic reticulum membrane. Part of protein complex involved in cell-cell adhesion. Is active in plasma membrane. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 45270251 | 45276653 | Mouse | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11670322 | IZUMO1 | izumo sperm-oocyte fusion 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); syncytium formation by plasma membrane fusion (ort holog); FOUND IN acrosomal vesicle (ortholog); endoplasmic reticulum membrane (ortholog); protein complex involved in cell-cell adhesion (ortholog) | 19 | 45740372 | 45747177 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12200661 | IZUMO1 | izumo sperm-oocyte fusion 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN syncytium formation by plasma membrane fusion (ortholog); FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); endopl asmic reticulum membrane (ortholog) | 1 | 107579073 | 107583163 | Dog | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 14298287 | IZUMO1 | izumo sperm-oocyte fusion 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN syncytium formation by plasma membrane fusion (ortholog); FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); endopl asmic reticulum membrane (ortholog) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18902738 | Izumo1 | izumo sperm-oocyte fusion 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); syncytium formation by plasma membrane fusion (ort holog); FOUND IN acrosomal vesicle (ortholog); endoplasmic reticulum membrane (ortholog); protein complex involved in cell-cell adhesion (ortholog) | | | | Naked Mole-Rat | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 40896528 | IZUMO1 | izumo sperm-oocyte fusion 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); syncytium formation by plasma membrane fusion (ort holog); FOUND IN acrosomal vesicle (ortholog); endoplasmic reticulum membrane (ortholog); protein complex involved in cell-cell adhesion (ortholog) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 38641733 | LOC105369787 | endogenous retrovirus group K member 21 Env polyprotein | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN syncytium formation by plasma membrane fusion; FOUND IN plasma membrane (inferred) | 12 | 58328381 | 58337040 | Human | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 151675571 | LOC124901580 | endogenous retrovirus group K member 6 Env polyprotein | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN syncytium formation by plasma membrane fusion; FOUND IN plasma membrane (inferred) | 7 | 4591852 | 4599507 | Human | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310975 | Pde12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to dsRNA (ortholog); cellular response to interferon-alpha (orthol og); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; amitrole | 16 | 1926807 | 1932383 | Rat | 108 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9017711 | Pde12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to dsRNA (ortholog); cellular response to interferon-alpha (orthol og); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | NW_004955430 | 7272911 | 7277726 | Chinchilla | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 11965771 | PDE12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (inferred); cellular response to dsRNA (inferred); cellular response to interferon-alpha (inferred); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | 3 | 57489602 | 57502240 | Bonobo | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 12151262 | PDE12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (inferred); cellular response to dsRNA (inferred); cellular response to interferon-alpha (inferred); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrion (ortholog) | 20 | 32884819 | 32890995 | Dog | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 12474425 | Pde12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (inferred); cellular response to dsRNA (inferred); cellular response to interferon-alpha (inferred); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | NW_004936473 | 7894026 | 7897844 | Squirrel | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 14257602 | PDE12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (inferred); cellular response to dsRNA (inferred); cellular response to interferon-alpha (inferred); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 18609481 | PDE12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (inferred); cellular response to dsRNA (inferred); cellular response to interferon-alpha (inferred); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Green Monkey | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 18919492 | Pde12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to dsRNA (ortholog); cellular response to interferon-alpha (ortholog); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Naked Mole-Rat | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 625886283 | Pde12 | phosphodiesterase 12 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); cellular response to dsRNA (ortholog); cellular response to interferon-alpha (orthol og); ASSOCIATED WITH Cardiovirus Infections (ortholog); respiratory syncytial virus infectious disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Black Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 1352538 | PSG1 | pregnancy specific beta-1-glycoprotein 1 | The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching con centrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009] | 19 | 42866464 | 42879713 | Human | 37 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344333 | PSG10P | pregnancy specific beta-1-glycoprotein 10, pseudogene | The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] | 19 | 42836997 | 42855718 | Human | 2 | description | gene, pseudo, PROVISIONAL [RefSeq] |
| 1353660 | PSG11 | pregnancy specific beta-1-glycoprotein 11 | The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] | 19 | 43007656 | 43026469 | Human | 21 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353998 | PSG5 | pregnancy specific beta-1-glycoprotein 5 | The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] | 19 | 43167743 | 43186536 | Human | 33 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346220 | PSG8 | pregnancy specific beta-1-glycoprotein 8 | The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] | 19 | 42752686 | 42765678 | Human | 20 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351216 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and regulation of syncytium formation by plasma membrane fusion. Located in several cellular components, including filopodium; lamellipodium; and microvillus. Implicated in nicotine dependence. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 47734363 | 47758880 | Human | 183 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557123 | Rsad2 | radical S-adenosyl methionine domain containing 2 | Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in several processes, including CD4-positive, alpha-beta T cell differentiation; negative regulation of viral genome replication; and positive regulation of immune response. Located in endoplasmic reticulum and lipid droplet. Is expressed in liver. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 26492742 | 26506451 | Mouse | 276 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8778396 | Rsad2 | radical S-adenosyl methionine domain containing 2 | ENCODES a protein that exhibits 4 iron, 4 sulfur cluster binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell activation (ortholog); CD4-positive, alpha-beta T cell differentiation (ortholog); defense response to virus (ortholog); ASSOCIATED WITH respiratory sync >syncytial virus infectious disease; Animal Disease Models (ortholog); congestive heart failure (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); lipid droplet (ortholog) | NW_004955487 | 1988226 | 2001731 | Chinchilla | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310078 | Sarm1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits double-stranded DNA binding (ortholog); identical protein binding (ortholog); NAD+ nucleosidase activity (ortholog); INVOLVED IN modification of postsynaptic structure; NAD+ catabolic process (ortholog); nervous system process (ortholog); ASSOCIATED WITH amyotrophic l ateral sclerosis (ortholog); respiratory syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane; glutamatergic synapse; cell surface (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 10 | 63867503 | 63890872 | Rat | 142 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8989021 | Sarm1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits double-stranded DNA binding (ortholog); identical protein binding (ortholog); NAD+ nucleosidase activity (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); NAD+ catabolic process (ortholog); nervous system process (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); respiratory syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955481 | 4743458 | 4763766 | Chinchilla | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 11915178 | SARM1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); regulation of apoptotic process (ortholog); response to glucose (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); respiratory sync ght:700;'>syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog) | 17 | 28370206 | 28403440 | Bonobo | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 12228796 | SARM1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); regulation of apoptotic process (ortholog); response to glucose (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); respiratory sync ght:700;'>syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog) | 9 | 42620878 | 42639662 | Dog | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 12438094 | Sarm1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); regulation of apoptotic process (ortholog); response to glucose (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); respiratory sync ght:700;'>syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog) | NW_004936538 | 4526713 | 4546861 | Squirrel | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 14194525 | SARM1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits double-stranded DNA binding (ortholog); identical protein binding (ortholog); NAD+ nucleosidase activity (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); NAD+ catabolic process (ortholog); nervous system process (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); respiratory syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 56 | description | gene, protein-coding, MODEL [RefSeq] |
| 18633971 | SARM1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); regulation of apoptotic process (ortholog); response to glucose (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); respiratory sync ght:700;'>syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog) | | | | Green Monkey | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918103 | Sarm1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); regulation of apoptotic process (ortholog); response to glucose (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); respiratory sync ght:700;'>syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN extrinsic component of synaptic membrane (ortholog); glutamatergic synapse (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 626088998 | Sarm1 | sterile alpha and TIR motif containing 1 | ENCODES a protein that exhibits double-stranded DNA binding (ortholog); identical protein binding (ortholog); NAD+ nucleosidase activity (ortholog); INVOLVED IN modification of postsynaptic structure (ortholog); NAD+ catabolic process (ortholog); nervous system process (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); respiratory syncytial virus infectious disease (ortholog); Vision Disorders (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 1552674 | Sftpa1 | surfactant associated protein A1 | Predicted to enable carbohydrate binding activity and metal ion binding activity. Predicted to be involved in positive regulation of phagocytosis. Located in collagen-containing extracellular matrix. Is expressed in extraembryonic component; lung; lung surfactant; and placenta. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 40853745 | 40858330 | Mouse | 200 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737198 | Sftpb | surfactant associated protein B | Predicted to be involved in respiratory gaseous exchange by respiratory system and sphingolipid metabolic process. Located in cytoplasm. Is expressed in lung surfactant and respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory sync 700;'>syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 72281594 | 72291354 | Mouse | 272 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733829 | Sftpc | surfactant associated protein C | Predicted to enable identical protein binding activity. Predicted to be involved in respiratory gaseous exchange by respiratory system. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung; lung surfactant; and main bronchus epithelium. Used to study desq uamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 70758381 | 70761521 | Mouse | 230 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11287 | Sftpd | surfactant associated protein D | Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in cytoplasm. Is expressed in epidermis spinous layer; lung; lung surfactant; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 40894169 | 40907155 | Mouse | 259 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731947 | SLC6A2 | solute carrier family 6 member 2 | This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic in tolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] | 16 | 55655988 | 55706192 | Human | 281 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736945 | Syt1 | synaptotagmin I | Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including Golgi apparatus; presynaptic membrane; and secretory vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 108333511 | 108846852 | Mouse | 399 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353248 | TAC3 | tachykinin precursor 3 | This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the li gand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] | 12 | 57010000 | 57016529 | Human | 161 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737014 | Tlr4 | toll-like receptor 4 | This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracel lular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015] | 4 | 66745788 | 66765338 | Mouse | 1600 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1618984 | Vash2 | vasohibin 2 | Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development; positive regulation of angiogenesis; and syncytium formation by plasma membrane fusion. Predicte d to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex intermediate zone; cerebral cortex ventricular layer; cortical plate; and hippocampus. Orthologous to human VASH2 (vasohibin 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 190679843 | 190711500 | Mouse | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
