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Gene: RAPGEF3 (Rap guanine nucleotide exchange factor 3) Homo sapiens
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Symbol: RAPGEF3
Name: Rap guanine nucleotide exchange factor 3
Description: Exhibits Rap guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including positive regulation of protein modification process; regulation of actin cytoskeleton organization; and regulation of syncytium formation by plasma membrane fusion. Localizes to filopodium; lamellipodium; and microvillus. Colocalizes with cortical actin cytoskeleton and plasma membrane. Biomarker of congestive heart failure; PARTICIPATES IN adenosine signaling pathway; long term potentiation; INTERACTS WITH 17alpha-ethynylestradiol; aflatoxin B1; aflatoxin B2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330170P05Rik; bcm910; CAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; EPAC; EPAC 1; EPAC1; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Orthologs:
Mus musculus (house mouse) : Rapgef3 (Rap guanine nucleotide exchange factor (GEF) 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rapgef3 (Rap guanine nucleotide exchange factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef3 (Rap guanine nucleotide exchange factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Canis lupus familiaris (dog) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef3 (Rap guanine nucleotide exchange factor 3)
Sus scrofa (pig) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Chlorocebus sabaeus (African green monkey) : RAPGEF3 (Rap guanine nucleotide exchange factor 3)
Heterocephalus glaber (naked mole-rat) : Rapgef3 (Rap guanine nucleotide exchange factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1247,734,363 - 47,771,040 (-)EnsemblGRCh38hg38GRCh38
GRCh381247,734,363 - 47,758,880 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,128,453 - 48,164,846 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,417,293 - 46,438,952 (-)NCBINCBI36hg18NCBI36
Build 341246,417,293 - 46,438,822NCBI
Celera1246,925,923 - 46,950,362 (-)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,159,564 - 45,184,005 (-)NCBIHuRef
CHM1_11248,094,358 - 48,118,798 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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External Database Links
Nomenclature History
 
More on RAPGEF3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351216
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.