| 1305332 | Mdm2 | MDM2 proto-oncogene | ENCODES a protein that exhibits p53 binding; peroxisome proliferator activated receptor binding; receptor serine/threonine kinase binding; INVOLVED IN cellular response to alkaloid; cellular response to antibiotic; cellular response to estrogen stimulus; PARTICIPATES IN altered p53 signaling pathway ; p53 signaling pathway; cell cycle pathway, mitotic; ASSOCIATED WITH Acute Experimental Pancreatitis; Brain Injuries; breast cancer; FOUND IN glutamatergic synapse; postsynaptic density; cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 55176558 | 55201757 | Rat | 835 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1313299 | MDM2 | MDM2 proto-oncogene | This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detect ed in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] | 12 | 68808172 | 68850686 | Human | 974 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313300 | Mdm2 | MDM2 proto-oncogene | Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control poin t of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 117524780 | 117546663 | Mouse | 1031 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8878547 | Mdm2 | MDM2 proto-oncogene | ENCODES a protein that exhibits 5S rRNA binding (ortholog); disordered domain specific binding (ortholog); enzyme binding (ortholog); INVOLVED IN amyloid fibril formation (ortholog); apoptotic process (ortholog); atrial septum development (ortholog); PARTICIPATES IN altered p53 signaling pathway; p5 3 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | NW_004955458 | 15264028 | 15287290 | Chinchilla | 282 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11965096 | MDM2 | MDM2 proto-oncogene | ENCODES a protein that exhibits p53 binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); blood vessel development (ort holog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 12 | 66322340 | 66357010 | Bonobo | 285 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12141521 | MDM2 | MDM2 proto-oncogene | ENCODES a protein that exhibits 5S rRNA binding (ortholog); p53 binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); INVOLVED IN apoptotic process (ortholog); atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); nucleolus (ortholog) | 10 | 10936288 | 10963118 | Dog | 298 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12568939 | Mdm2 | MDM2 proto-oncogene | ENCODES a protein that exhibits 5S rRNA binding (ortholog); disordered domain specific binding (ortholog); enzyme binding (ortholog); INVOLVED IN amyloid fibril formation (ortholog); atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN altered p53 si gnaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN glutamatergic synapse (ortholog); nuclear body (ortholog); postsynaptic density (ortholog) | NW_004936545 | 6709903 | 6732334 | Squirrel | 288 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14269393 | MDM2 | MDM2 proto-oncogene | ENCODES a protein that exhibits p53 binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); blood vessel development (ort holog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 287 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18343082 | MDM2 | MDM2 proto-oncogene | ENCODES a protein that exhibits p53 binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); blood vessel development (ort holog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Green Monkey | 285 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18932819 | Mdm2 | MDM2 proto-oncogene | ENCODES a protein that exhibits identical protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN apoptotic process (inferred); atrial septum development (inferred); atrioventricular valve morphogenesis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferre d); nucleolus (inferred) | | | | Naked Mole-Rat | 32 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155234473 | mdm2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625894474 | Mdm2 | MDM2 proto-oncogene | ENCODES a protein that exhibits 5S rRNA binding (ortholog); disordered domain specific binding (ortholog); enzyme binding (ortholog); INVOLVED IN amyloid fibril formation (ortholog); apoptotic process (ortholog); atrial septum development (ortholog); PARTICIPATES IN altered p53 signaling pathway; p5 3 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 280 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155234472 | mdm2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234683 | mdm2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12730419 | LOC101971676 | E3 ubiquitin-protein ligase Mdm2-like | | NW_004936479 | 5698784 | 5700268 | Squirrel | | old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16552663 | AC068044.1 | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) (MDM2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1354048 | MTBP | MDM2 binding protein | This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012] | 8 | 120445419 | 120523636 | Human | 78 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1565672 | Mtbp | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (ortholog); kin etochore (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 7 | 88862939 | 88945491 | Rat | 79 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1619910 | Mtbp | MDM2 binding protein | Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; cerebral cortex subventricular zone; midbrain ventricular la yer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 55420800 | 55489819 | Mouse | 85 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8998783 | Mtbp | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (ortholog); kin etochore (ortholog) | NW_004955417 | 25824251 | 25893752 | Chinchilla | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12048500 | MTBP | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kin etochore (inferred) | 8 | 117135172 | 117213360 | Bonobo | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12318637 | MTBP | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kin etochore (inferred) | 13 | 19313884 | 19385370 | Dog | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12447263 | Mtbp | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kin etochore (inferred) | NW_004936470 | 26312670 | 26386410 | Squirrel | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13948040 | MTBP | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kin etochore (inferred) | | | | Pig | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18593555 | MTBP | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kin etochore (inferred) | | | | Green Monkey | 14 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18907683 | Mtbp | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (ortholog) | | | | Naked Mole-Rat | 13 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626075217 | Mtbp | MDM2 binding protein | INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (ortholog); kin etochore (ortholog) | | | | Black Rat | 10 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12130667 | LOC100685810 | E3 ubiquitin-protein ligase Mdm2-like | | 17 | 16889320 | 16890920 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 12091707 | LOC100688548 | E3 ubiquitin-protein ligase Mdm2-like | | 31 | 3529493 | 3531093 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18930517 | LOC101717114 | E3 ubiquitin-protein ligase Mdm2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12540479 | LOC101975953 | E3 ubiquitin-protein ligase Mdm2-like | | NW_004936874 | 485698 | 487130 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18913929 | LOC106007849 | E3 ubiquitin-protein ligase Mdm2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 40908499 | LOC119870519 | E3 ubiquitin-protein ligase Mdm2-like | | | | | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 18900993 | LOC101699416 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18920780 | LOC101703233 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18905524 | LOC101722801 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18918733 | LOC101725131 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8915499 | LOC102012960 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | NW_004955416 | 14407621 | 14422095 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 8969000 | LOC102020442 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | NW_004955415 | 10720955 | 10722285 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 8835896 | LOC102027875 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | NW_004955496 | 5554541 | 5559086 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 18915159 | LOC106008042 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18917038 | LOC106009417 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18900776 | LOC106010671 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18930682 | LOC110348135 | E3 ubiquitin-protein ligase Mdm2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 38673075 | LOC100130841 | MDM2 oncogene, E3 ubiquitin protein ligase pseudogene | | 2 | 22188333 | 22188847 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16561576 | LOC124902995 | probable ribosome biogenesis protein RLP24 | | 12 | 98794485 | 98795010 | Human | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 1309306 | Mdm4 | MDM4 regulator of p53 | ENCODES a protein that exhibits enzyme activator activity (ortholog); enzyme binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pa thway; ASSOCIATED WITH Alzheimer's disease (ortholog); Bone Marrow Failure Syndrome 6 (ortholog); Breast Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 46922236 | 47068241 | Rat | 176 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319584 | MDM4 | MDM4 regulator of p53 | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] | 1 | 204516406 | 204558120 | Human | 202 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1319585 | Mdm4 | MDM4 regulator of p53 | This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded prot ein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014] | 1 | 132913843 | 132958325 | Mouse | 274 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1312969 | TBRG1 | transforming growth factor beta regulator 1 | Involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 124622864 | 124635926 | Human | 88 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312970 | Tbrg1 | transforming growth factor beta regulated gene 1 | Predicted to be involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cranium; genitourinary system; jaw; liver ; and spleen. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 37560478 | 37568608 | Mouse | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 14380554 | MDM20 | | | | | | Yeast | | symbol | gene, null |
| 1305685 | Naa25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | FOUND IN cytoplasm; cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil | 12 | 40758909 | 40811192 | Rat | 66 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1313860 | Naa25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; hai r; heart; spinal cord; and stomach. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 121535977 | 121580612 | Mouse | 79 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605042 | NAA25 | N-alpha-acetyltransferase 25, NatB auxiliary subunit | This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010] | 12 | 112026689 | 112108783 | Human | 63 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731337 | USP2 | ubiquitin specific peptidase 2 | This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiqu itinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 11 | 119355215 | 119381690 | Human | 261 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 620002 | Cdk5rap3 | CDK5 regulatory subunit associated protein 3 | ENCODES a protein that exhibits protein-containing complex binding; cyclin binding (ortholog); MDM2/MDM4 family protein binding (ortholog); INVOLVED IN negative regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of cyclin-depende nt protein serine/threonine kinase activity; apoptotic nuclear changes (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 82390845 | 82402814 | Rat | 199 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8726125 | Cdk5rap3 | CDK5 regulatory subunit associated protein 3 | ENCODES a protein that exhibits cyclin binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase binding (ortholog); INVOLVED IN apoptotic nuclear changes (ortholog); cell population proliferation (ortholog); definitive er ythrocyte differentiation (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955451 | 13160811 | 13170012 | Chinchilla | 62 | description | gene, protein-coding, MODEL [RefSeq] |
| 11753825 | CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | ENCODES a protein that exhibits cyclin binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase binding (ortholog); INVOLVED IN apoptotic nuclear changes (ortholog); cell population proliferation (ortholog); definitive er ythrocyte differentiation (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | 17 | 9556313 | 9567099 | Bonobo | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 18912812 | Cdk5rap3 | CDK5 regulatory subunit associated protein 3 | ENCODES a protein that exhibits cyclin binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase binding (ortholog); INVOLVED IN apoptotic nuclear changes (ortholog); cell population proliferation (ortholog); definitive er ythrocyte differentiation (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 626084248 | Cdk5rap3 | CDK5 regulatory subunit associated protein 3 | ENCODES a protein that exhibits cyclin binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase binding (ortholog); INVOLVED IN apoptotic nuclear changes (ortholog); cell population proliferation (ortholog); definitive er ythrocyte differentiation (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 62 | description | gene, protein-coding, MODEL [RefSeq] |
| 10322 | Cdkn2a | cyclin dependent kinase inhibitor 2A | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to gamma radiation ; negative regulation of lymphocyte proliferation; and positive regulation of apoptotic process. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 89192710 | 89212856 | Mouse | 1223 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737039 | CDKN2A | cyclin dependent kinase inhibitor 2A | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript i ncludes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012] | 9 | 21967752 | 21995324 | Human | 1906 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1308993 | Marchf7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (ortholog); MDM2/MDM4 family protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of DNA damage response, signal transduction b y p53 class mediator (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 65090640 | 65128768 | Rat | 110 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8807902 | Marchf7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (ortholog); MDM2/MDM4 family protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of DNA damage response, signal transduction b y p53 class mediator (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955449 | 13834561 | 13875864 | Chinchilla | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 11678663 | MARCHF7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (inferred); MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); regulation of tolerance induction (ortholog); FOUND IN centr osome (inferred); cytoplasm (inferred); cytosol (inferred) | 2B | 47004211 | 47059901 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12189917 | MARCHF7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (inferred); MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); regulation of tolerance induction (ortholog); FOUND IN centr osome (inferred); cytoplasm (inferred); cytosol (inferred) | 36 | 5481449 | 5533139 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12684896 | Marchf7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (inferred); MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); regulation of tolerance induction (ortholog); FOUND IN centr osome (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936469 | 18966239 | 19016829 | Squirrel | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 14245927 | MARCHF7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (inferred); MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); regulation of tolerance induction (ortholog); FOUND IN centr osome (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 18661185 | MARCHF7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (inferred); MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); regulation of tolerance induction (ortholog); FOUND IN centr osome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18932425 | Marchf7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (ortholog); MDM2/MDM4 family protein binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of DNA damage response, signal transduction by p53 class mediator (ortholog ); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 626155783 | Marchf7 | membrane associated ring-CH-type finger 7 | ENCODES a protein that exhibits enzyme binding (ortholog); MDM2/MDM4 family protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of DNA damage response, signal transduction b y p53 class mediator (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 1348962 | NUMB | NUMB endocytic adaptor protein | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS 15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 14 | 73275216 | 73458546 | Human | 153 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 3369 | Ppara | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding; MDM2/MDM4 family protein binding; mitogen-activated protein kinase kinase kinase binding; INVOLVED IN behavioral response to nicotine; cellular response to fructose stimulus; fatty acid me tabolic process; PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; ASSOCIATED WITH alcohol use disorder; alcoholic hepatitis; Brain Injuries; FOUND IN fibrillar center (ortholog); nuclear body (ortholog); nucleus (ortholog); INTERACTS WITH (+)-catechin; (+)-schisandrin B; (3-phenoxyphenyl)methanol | 7 | 118712261 | 118780723 | Rat | 1519 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11757610 | PPARA | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog) | | | | Bonobo | 224 | description | gene, protein-coding, MODEL [RefSeq] |
| 12618260 | Ppara | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog) | NW_004936629 | 3672445 | 3725645 | Squirrel | 226 | description | gene, protein-coding, MODEL [RefSeq] |
| 14213069 | PPARA | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN fibrillar center (inferred); nuclear body (inferred); nucleus (inferred); INTERACTS WITH bezafibrate; cadmium atom; cadmium dichloride | | | | Pig | 244 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18369218 | PPARA | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 224 | description | gene, protein-coding, MODEL [RefSeq] |
| 18905207 | Ppara | peroxisome proliferator activated receptor alpha | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog) | | | | Naked Mole-Rat | 229 | description | gene, protein-coding, MODEL [RefSeq] |
| 1306996 | Psme3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); identical protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (ortholog); regulation of pro teasomal protein catabolic process (ortholog); PARTICIPATES IN antigen processing and presentation pathway; hepatitis C pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 10 | 86757933 | 86765719 | Rat | 117 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315928 | Psme3 | proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) | Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S t ransition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 101206090 | 101214363 | Mouse | 167 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8968450 | Psme3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); identical protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (ortholog); regulation of pro teasomal protein catabolic process (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955451 | 16631379 | 16637331 | Chinchilla | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 11711406 | PSME3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); identical protein binding (inferred); MDM2/MDM4 family protein binding (inferred); INVOLVED IN apoptotic process (inferred); negative regulation of extrinsic apoptotic signaling pathway (inferred); regulation of G1/S transition of mitotic cell cycle (inferred); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred) | 17 | 14474604 | 14484522 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12158331 | PSME3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); identical protein binding (inferred); MDM2/MDM4 family protein binding (inferred); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (inferred); regulation of pro teasomal protein catabolic process (inferred); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN nucleoplasm (inferred); proteasome activator complex (inferred); proteasome complex (inferred) | 9 | 20185997 | 20193320 | Dog | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12545353 | Psme3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); identical protein binding (inferred); MDM2/MDM4 family protein binding (inferred); INVOLVED IN antigen processing and presentation of exogenous antigen (inferred); negative regulation o f extrinsic apoptotic signaling pathway (inferred); regulation of G1/S transition of mitotic cell cycle (inferred); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred) | NW_004936490 | 17542933 | 17549347 | Squirrel | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 14098234 | PSME3 | proteasome activator subunit 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 40 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18565438 | PSME3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (inferred); identical protein binding (inferred); MDM2/MDM4 family protein binding (inferred); INVOLVED IN apoptotic process (inferred); negative regulation of extrinsic apoptotic signaling pathway (inferred); regulation of G1/S transition of mitotic cell cycle (inferred); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred) | | | | Green Monkey | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18901240 | Psme3 | proteasome activator subunit 3 | ENCODES a protein that exhibits identical protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred) | | | | Naked Mole-Rat | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 626095708 | Psme3 | proteasome activator subunit 3 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); identical protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); INVOLVED IN negative regulation of extrinsic apoptotic signaling pathway (ortholog); regulation of pro teasomal protein catabolic process (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 1606702 | PYHIN1 | pyrin and HIN domain family member 1 | The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiat ion, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 1 | 158931552 | 158990870 | Human | 55 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1305243 | Rfwd3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); int erstrand cross-link repair (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH bisphenol A; cobalt dichloride; ochratoxin A | 19 | 56145221 | 56177871 | Rat | 106 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1349611 | RFWD3 | ring finger and WD repeat domain 3 | Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 74621399 | 74666877 | Human | 246 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1618142 | Rfwd3 | ring finger and WD repeat domain 3 | Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group W. Orthologous to human RFWD3 (ring finger and WD repeat domain 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 111997576 | 112026854 | Mouse | 147 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9059602 | Rfwd3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); int erstrand cross-link repair (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955484 | 2824057 | 2857321 | Chinchilla | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 11765674 | RFWD3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferre d); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 16 | 55187178 | 55233265 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12296336 | RFWD3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferre d); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear body (inferred) | 5 | 75960909 | 76001088 | Dog | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 12672681 | Rfwd3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferre d); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936475 | 23544974 | 23586716 | Squirrel | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 14116963 | RFWD3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferre d); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18459763 | RFWD3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); p53 binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via homologous recombination (inferre d); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18920287 | Rfwd3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); INVOLVED IN double-strand break repair via homologous recombination (ortholog); mitotic G1 DNA damage checkpoint signaling (ortholog); regulation of DNA damage c heckpoint (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); site of DNA damage (ortholog) | | | | Naked Mole-Rat | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 626103014 | Rfwd3 | ring finger and WD repeat domain 3 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); p53 binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN DNA damage response (ortholog); double-strand break repair via homologous recombination (ortholog); int erstrand cross-link repair (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group W (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 8760228 | Rpl37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (ortholog); cytosolic large ribosomal subunit (ortholog); cytosolic ribosome (ortholog) | NW_004955426 | 25120024 | 25122559 | Chinchilla | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 12011464 | RPL37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); RNA binding (inferred); INVOLVED IN cytoplasmic translation (inferred); positive regulation of signal transduction by p53 class mediator (inferred); transl ation (inferred); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (inferred); cytosolic large ribosomal subunit (inferred); cytosolic ribosome (inferred) | 5 | 69551852 | 69554735 | Bonobo | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 12246901 | RPL37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytosolic ribosome (ortholog); synapse (ortholog) | 12 | 39026975 | 39027322 | Dog | 21 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12593766 | Rpl37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (ortholog); cytosolic ribosome (ortholog); synapse (ortholog) | NW_004936518 | 1783559 | 1785681 | Squirrel | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 14072885 | RPL37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); metal ion binding (inferred); RNA binding (inferred); INVOLVED IN cytoplasmic translation (inferred); positive regulation of signal transduction by p53 class mediator (inferred); transl ation (inferred); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (inferred); cytosolic large ribosomal subunit (inferred); cytosolic ribosome (inferred); INTERACTS WITH graphene oxide | | | | Pig | 23 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18435613 | RPL37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytosolic ribosome (ortholog); synapse (ortholog) | | | | Green Monkey | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 18935903 | Rpl37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytosolic ribosome (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 41394010 | Rpl37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (ortholog); cytosolic large ribosomal subunit (ortholog); cytosolic ribosome (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 55942827 | 55944905 | Rat | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 625842870 | Rpl37 | ribosomal protein L37 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN cytoplasmic translation (ortholog); positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; FOUND IN cytoplasm (ortholog); cytosolic large ribosomal subunit (ortholog); cytosolic ribosome (ortholog) | | | | Black Rat | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 5146665 | Rpl37rt | ribosomal protein L37, retrotransposed | Predicted to enable MDM2/MDM4 family protein binding activity; growth factor binding activity; and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction b y p53 class mediator. Predicted to be located in cytosolic ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL37 (ribosomal protein L37). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 115240981 | 115248327 | Mouse | 12 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 62026 | Rps15 | ribosomal protein S15 | ENCODES a protein that exhibits structural constituent of ribosome; MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN liver regeneration; ribosomal small subunit assembly; positive regulation of signal trans duction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH insulinoma; Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytosolic small ribosomal subunit; nucleoplasm; synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 7 | 10066572 | 10068167 | Rat | 167 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8972884 | Rps15 | ribosomal protein S15 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN liver regeneration (ortholog); positive regulation of signal transduction by p 53 class mediator (ortholog); ribosomal small subunit assembly (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Disease Progression (ortholog); insulinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosolic ribosome (ortholog); cytosolic small ribosomal subunit (ortholog) | NW_004955495 | 6492968 | 6495435 | Chinchilla | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 12136554 | RPS15 | ribosomal protein S15 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN liver regeneration (ortholog); positive regulation of signal transduction by p 53 class mediator (ortholog); ribosomal small subunit assembly (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Disease Progression (ortholog); insulinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosolic ribosome (ortholog); cytosolic small ribosomal subunit (ortholog) | 20 | 57406544 | 57407015 | Dog | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 14213352 | RPS15 | ribosomal protein S15 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN liver regeneration (ortholog); positive regulation of signal transduction by p 53 class mediator (ortholog); ribosomal small subunit assembly (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Disease Progression (ortholog); insulinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane; cytosolic small ribosomal subunit; cytosolic ribosome (ortholog) | | | | Pig | 33 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 329330748 | RPS15 | ribosomal protein S15 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); ribosomal small subunit biogenesis (ortholog); r ibosomal small subunit export from nucleus (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytosolic ribosome (ortholog) | | | | Bonobo | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 625989843 | Rps15 | ribosomal protein S15 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN liver regeneration (ortholog); positive regulation of signal transduction by p 53 class mediator (ortholog); ribosomal small subunit assembly (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Disease Progression (ortholog); insulinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosolic ribosome (ortholog); cytosolic small ribosomal subunit (ortholog) | | | | Black Rat | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 621037 | Rps20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); P ARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytosolic small ribosomal subunit; cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 21616687 | 21618068 | Rat | 168 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8867228 | Rps20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); P ARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | NW_004955454 | 15151065 | 15152301 | Chinchilla | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 11702101 | RPS20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; tra nslation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | 8 | 52519658 | 52521152 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12177020 | RPS20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; tra nslation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | 29 | 7488481 | 7489850 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 14033695 | RPS20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); RNA binding (inferred); structural constituent of ribosome (inferred); INVOLVED IN positive regulation of signal transduction by p53 class mediator (inferred); translation (inferred); P ARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane; cytosolic small ribosomal subunit; synapse (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 37 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18540574 | RPS20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (inferred); RNA binding (inferred); structural constituent of ribosome (inferred); INVOLVED IN positive regulation of signal transduction by p53 class mediator (inferred); translation (inferred); P ARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosolic small ribosomal subunit (ortholog) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922334 | Rps20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); PARTICIPATES IN ribosome biogenesis pathway; tra nslation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | | | | Naked Mole-Rat | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 625914782 | Rps20 | ribosomal protein S20 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding (ortholog); structural constituent of ribosome (ortholog); ubiquitin ligase inhibitor activity (ortholog); INVOLVED IN positive regulation of signal transduction by p53 class mediator (ortholog); P ARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH Colorectal Cancer 10 (ortholog); Diamond-Blackfan anemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | | | | Black Rat | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 3889 | Tp53 | tumor protein p53 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; INVOLVED IN apoptotic signaling pathway; cellular response to heat; cellular response to hypoxia ; PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; lung non-small cell carcinoma pathway; ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH bronchiolo-alveolar adenocarcinoma; bronchopulmonary dysplasia; colorectal cancer; FOUND IN chromatin; nucleus; PML body; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B | 10 | 54798871 | 54810300 | Rat | 4013 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11772827 | TP53 | tumor protein p53 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose starvation (ortholog); cellular response to heat (ortholog); cellul ar response to hypoxia (ortholog); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; lung non-small cell carcinoma pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog) | 17 | 7699449 | 7717812 | Bonobo | 1150 | description | gene, protein-coding, MODEL [RefSeq] |
| 12482121 | Tp53 | tumor protein p53 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose starvation (ortholog); cellular response to heat (ortholog); cellul ar response to hypoxia (ortholog); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; lung non-small cell carcinoma pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog) | NW_004936595 | 919807 | 935367 | Squirrel | 1148 | description | gene, protein-coding, MODEL [RefSeq] |
| 18495585 | TP53 | tumor protein p53 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); MDM2/MDM4 family protein binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose starvation (ortholog); cellular response to heat (ortholog); cellul ar response to hypoxia (ortholog); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; lung non-small cell carcinoma pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog) | | | | Green Monkey | 1149 | description | gene, protein-coding, MODEL [RefSeq] |
| 1348223 | ZNF280B | zinc finger protein 280B | The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015] | 22 | 22484421 | 22509154 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] |
