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Gene: USP2 (ubiquitin specific peptidase 2) Homo sapiens
Symbol: USP2
Name: ubiquitin specific peptidase 2
Description: Exhibits cyclin binding activity; thiol-dependent ubiquitin-specific protease activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; protein deubiquitination; and protein stabilization. Predicted to localize to cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific protease 12; ubiquitin specific protease 2; ubiquitin specific protease 9; ubiquitin thioesterase 2; ubiquitin thiolesterase 2; ubiquitin-specific-processing protease 2; UBP41; USP9
Mus musculus (house mouse) : Usp2 (ubiquitin specific peptidase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp2 (ubiquitin specific peptidase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp2 (ubiquitin specific peptidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : USP2 (ubiquitin specific peptidase 2)
Canis lupus familiaris (dog) : USP2 (ubiquitin specific peptidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp2 (ubiquitin specific peptidase 2)
Sus scrofa (pig) : USP2 (ubiquitin specific peptidase 2)
Chlorocebus sabaeus (African green monkey) : USP2 (ubiquitin specific peptidase 2)
Heterocephalus glaber (naked mole-rat) : Usp2 (ubiquitin specific peptidase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11119,355,215 - 119,381,711 (-)EnsemblGRCh38hg38GRCh38
GRCh3811119,355,215 - 119,381,690 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711119,225,925 - 119,252,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,732,163 - 118,757,575 (-)NCBINCBI36hg18NCBI36
Build 3411118,732,754 - 118,740,102NCBI
Celera11116,386,596 - 116,413,112 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11115,167,582 - 115,194,094 (-)NCBIHuRef
CHM1_111119,112,501 - 119,139,031 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on USP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731337
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.