MTBP (MDM2 binding protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MTBP (MDM2 binding protein) Sus scrofa
Analyze
Symbol: MTBP
Name: MDM2 binding protein
RGD ID: 13948040
Description: INVOLVED IN negative regulation of cell population proliferation (ortholog); negative regulation of mitotic nuclear division (ortholog); protein localization to kinetochore (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); prostate cancer (ortholog); FOUND IN chromatin (inferred); kinetochore (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; mdm2-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl418,532,041 - 18,608,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1418,533,201 - 18,608,702 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2419,561,245 - 19,634,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA)
kinetochore  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MTBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl418,532,041 - 18,608,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1418,533,201 - 18,608,702 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2419,561,245 - 19,634,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388120,445,419 - 120,523,636 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8120,445,400 - 120,542,133 (+)EnsemblGRCh38hg38GRCh38
GRCh378121,457,659 - 121,535,876 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368121,526,847 - 121,605,056 (+)NCBINCBI36Build 36hg18NCBI36
Build 348121,526,846 - 121,605,056NCBI
Celera8117,646,783 - 117,724,262 (+)NCBICelera
Cytogenetic Map8q24.12NCBI
HuRef8116,778,264 - 116,856,242 (+)NCBIHuRef
CHM1_18121,498,133 - 121,576,374 (+)NCBICHM1_1
T2T-CHM13v2.08121,574,164 - 121,652,088 (+)NCBIT2T-CHM13v2.0
Mtbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391555,420,800 - 55,489,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1555,420,804 - 55,489,819 (+)EnsemblGRCm39 Ensembl
GRCm381555,557,404 - 55,626,423 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1555,557,408 - 55,626,423 (+)EnsemblGRCm38mm10GRCm38
MGSCv371555,388,963 - 55,457,978 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361555,387,491 - 55,456,506 (+)NCBIMGSCv36mm8
Celera1557,089,509 - 57,158,717 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1522.05NCBI
Mtbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,862,939 - 88,945,491 (+)NCBIGRCr8
mRatBN7.2786,973,215 - 87,055,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl786,973,069 - 87,050,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx788,855,242 - 88,932,641 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0791,056,452 - 91,133,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,861,600 - 90,939,217 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0795,309,928 - 95,392,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl795,309,928 - 95,387,680 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0795,931,981 - 96,014,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4792,068,823 - 92,146,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera783,766,024 - 83,843,938 (+)NCBICelera
Cytogenetic Map7q32NCBI
Mtbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541725,824,441 - 25,893,521 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541725,824,251 - 25,893,752 (+)NCBIChiLan1.0ChiLan1.0
MTBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27137,870,290 - 137,949,185 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18113,382,407 - 113,461,292 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08117,135,172 - 117,213,360 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18119,903,633 - 119,980,911 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8119,903,633 - 119,980,911 (+)Ensemblpanpan1.1panPan2
MTBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11319,313,884 - 19,385,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1319,313,973 - 19,384,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1319,326,458 - 19,397,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01319,644,280 - 19,710,517 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1319,644,293 - 19,710,518 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11319,370,182 - 19,441,624 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01319,469,965 - 19,541,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01319,703,083 - 19,774,639 (+)NCBIUU_Cfam_GSD_1.0
Mtbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530318,886,554 - 18,960,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647026,312,590 - 26,386,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647026,312,670 - 26,386,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18115,023,272 - 115,109,948 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8115,029,029 - 115,102,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603925,167,044 - 25,253,027 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476318,228,252 - 18,299,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476318,228,820 - 18,299,706 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTBP
2611 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 3 5 3 3 3
Below cutoff 1 2 2 16 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006578   ⟹   ENSSSCP00000006403
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl418,532,041 - 18,608,602 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000064413   ⟹   ENSSSCP00000039561
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl418,535,588 - 18,608,589 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000072638   ⟹   ENSSSCP00000060540
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl418,532,002 - 18,608,604 (-)Ensembl
RefSeq Acc Id: XM_001924836   ⟹   XP_001924871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1418,535,180 - 18,608,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021088982   ⟹   XP_020944641
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1418,533,201 - 18,608,702 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020944641   ⟸   XM_021088982
- Peptide Label: isoform X2
- UniProtKB: A0A8D0U864 (UniProtKB/TrEMBL),   A0A8D1ARH0 (UniProtKB/TrEMBL),   A0A8D1HHI6 (UniProtKB/TrEMBL),   A0A8D1T8P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001924871   ⟸   XM_001924836
- Peptide Label: isoform X1
- UniProtKB: A0A8D1VS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000039561   ⟸   ENSSSCT00000064413
RefSeq Acc Id: ENSSSCP00000006403   ⟸   ENSSSCT00000006578
RefSeq Acc Id: ENSSSCP00000060540   ⟸   ENSSSCT00000072638
Protein Domains
DM2   MDN2-binding protein C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015059016 UniProtKB/TrEMBL
  ENSSSCG00035062656 UniProtKB/TrEMBL
  ENSSSCG00045016052 UniProtKB/TrEMBL
  ENSSSCG00050020243 UniProtKB/TrEMBL
  ENSSSCG00060048694 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006578 ENTREZGENE
  ENSSSCT00000006578.5 UniProtKB/TrEMBL
  ENSSSCT00015078838.1 UniProtKB/TrEMBL
  ENSSSCT00035084201.1 UniProtKB/TrEMBL
  ENSSSCT00045027297.1 UniProtKB/TrEMBL
  ENSSSCT00050027281.1 UniProtKB/TrEMBL
  ENSSSCT00060066162.1 UniProtKB/TrEMBL
InterPro MTBP UniProtKB/TrEMBL
  MTBP_C UniProtKB/TrEMBL
  MTBP_central UniProtKB/TrEMBL
  MTBP_N UniProtKB/TrEMBL
NCBI Gene MTBP ENTREZGENE
PANTHER MDM2-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR14382 UniProtKB/TrEMBL
Pfam MTBP_C UniProtKB/TrEMBL
  MTBP_mid UniProtKB/TrEMBL
  MTBP_N UniProtKB/TrEMBL
UniProt A0A8D0U864 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ARH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HHI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1T8P4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1VS80 ENTREZGENE, UniProtKB/TrEMBL
  F1S287_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90437 ENTREZGENE