Nfe2l2 (NFE2 like bZIP transcription factor 2) - Rat Genome Database

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Gene: Nfe2l2 (NFE2 like bZIP transcription factor 2) Rattus norvegicus
Analyze
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
RGD ID: 620360
Description: Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule biosynthetic process; and regulation of cell migration. Located in nucleus. Used to study diabetic retinopathy; liver disease (multiple); middle cerebral artery infarction; myocardial infarction; and pulmonary fibrosis. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); metabolic dysfunction-associated steatohepatitis; neurodegenerative disease (multiple); and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2); PARTICIPATES IN oxidative stress response pathway; nuclear factor, erythroid 2 like 2 signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-taxifolin; (-)-selegiline; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NF-E2-related factor 2; NFE2-related factor 2; nrf2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nfe2l2em1Mcwi ; Nfe2l2em1Kyo ; Nfe2l2em2Kyo
Genetic Models: SD-Nfe2l2em1Mcwi ; SD-Nfe2l2em1Mcwi-/- ; F344-Nfe2l2em2Kyo ; F344-Nfe2l2em1Kyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,001,529 - 81,031,165 (-)NCBIGRCr8
mRatBN7.2360,594,239 - 60,621,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,968,507 - 63,995,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,552,163 - 72,579,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,318,419 - 70,345,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Nfe2l2Ratacute kidney failure treatmentIEP 10412697 RGD 
Nfe2l2RatAlcoholic Liver Diseases treatmentISORGD:73443221201307 RGD 
Nfe2l2RatAlcoholic Liver Diseases severityISORGD:73443121201311DNA:SNP:promoter:rs35652124(human)RGD 
Nfe2l2RatAlzheimer's disease treatmentISORGD:73443110412689 RGD 
Nfe2l2RatAlzheimer's disease treatmentIEP 10412685 RGD 
Nfe2l2RatAlzheimer's disease onsetISORGD:7344316893326DNA:snps, haplotype:5' utr, intron:multiple (human)RGD 
Nfe2l2RatAlzheimer's disease  ISORGD:73443210412683protein:increased expression:brain, nucleusRGD 
Nfe2l2Ratamyotrophic lateral sclerosis  ISORGD:7344316893397mRNA, protein:decreased expression:primary motor cortex, spinal cord (human)RGD 
Nfe2l2Ratamyotrophic lateral sclerosis treatmentISORGD:73443210412690 RGD 
Nfe2l2Ratasthma severityISORGD:7344316893376mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human)RGD 
Nfe2l2RatBrain Injuries  IEP 5134971protein:increased expression:lung:RGD 
Nfe2l2RatBrain Injuries  IEP 11576302 RGD 
Nfe2l2RatCardiac Fibrosis treatmentIEP 401793732 RGD 
Nfe2l2RatCardiomegaly treatmentIEP 401793732 RGD 
Nfe2l2Ratcataract disease_progressionISORGD:7344316893326DNA:snps, haplotype:5' utr, intron:multiple (human)RGD 
Nfe2l2RatChemical and Drug Induced Liver Injury  ISORGD:7344326893370 RGD 
Nfe2l2RatChemical and Drug Induced Liver Injury treatmentIEP 21201283 RGD 
Nfe2l2RatChemical and Drug Induced Liver Injury treatmentIEP 21201280 RGD 
Nfe2l2RatChemical and Drug Induced Liver Injury treatmentIEP 15090820 RGD 
Nfe2l2RatChemical and Drug Induced Liver Injury treatmentIEP 21201308induced by methotrexate (CHEBI:44185), treated by ferulic acid (CHEBI:17620)RGD 
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Nfe2l2Ratcolorectal cancer  ISORGD:7344318554872ClinVar Annotator: match by term: Colorectal cancerClinVarPMID:29018201
Nfe2l2RatIMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA  ISORGD:7344318554872ClinVar Annotator: match by term: Immunodeficiency, developmental delay, and hypohomocysteinemia | ClinVar Annotator: match by more ...ClinVarPMID:24130096|PMID:24728327|PMID:25741868|PMID:28492532|PMID:29018201|PMID:31107239
Nfe2l2Ratlung cancer  ISORGD:7344318554872ClinVar Annotator: match by term: Lung cancerClinVar 
Nfe2l2RatNeurodevelopmental Disorders  ISORGD:7344318554872ClinVar Annotator: match by term: Neurodevelopmental abnormalityClinVar 
Nfe2l2Ratrenal cell carcinoma  ISORGD:7344318554872ClinVar Annotator: match by term: Renal adenocarcinomaClinVarPMID:26619011
Nfe2l2Ratsplit hand-foot malformation 5  ISORGD:7344318554872ClinVar Annotator: match by term: Split hand-foot malformation 5ClinVarPMID:25741868
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Nfe2l2RatAcidoses  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:29618784
Nfe2l2Ratacute kidney failure  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:24958931
Nfe2l2RatAcute Lung Injury  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:24812154
Nfe2l2Ratallergic contact dermatitis  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:23564646
Nfe2l2Ratamyotrophic lateral sclerosis  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:27012417
Nfe2l2RatAnimal Disease Models  ISORGD:73443111554173CTD Direct Evidence: marker/mechanism|therapeuticCTDPMID:27012417|PMID:29255069
Nfe2l2RatBirth Weight  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:39038764
Nfe2l2RatBreast Neoplasms  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:32621833
Nfe2l2RatCarcinogenesis  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:29228771
Nfe2l2RatCardiac Output, Low  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:30096613
Nfe2l2RatChemical and Drug Induced Liver Injury  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:22491424|PMID:22627062|PMID:24813929|PMID:26958860|PMID:30215777
Nfe2l2Ratcholestasis  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:20977460
Nfe2l2RatChromosome Breakage  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:27774770
Nfe2l2Ratcongestive heart failure  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:28373008
Nfe2l2RatDiabetic Nephropathies  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:20103708
Nfe2l2RatDisease Progression  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:32621833
Nfe2l2RatDrug-Related Side Effects and Adverse Reactions  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:20605904
Nfe2l2RatEmphysema  ISORGD:73443111554173CTD Direct Evidence: therapeuticCTDPMID:20133372
Nfe2l2Ratendocrine system disease  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:38043716
Nfe2l2RatEndometrial Neoplasms  ISORGD:73443111554173CTD Direct Evidence: marker/mechanismCTDPMID:20530669
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Nfe2l2RatIMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA  ISORGD:7344317240710 OMIM 

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Nfe2l2Rat(+)-albicanol multiple interactionsISORGD:7344326480464albicanol inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; albicanol inhibits the more ...CTDPMID:33761044
Nfe2l2Rat(+)-alpha-viniferin multiple interactionsISORGD:7344326480464[NFE2L2 protein results in increased expression of HMOX1] affects the reaction [alpha-viniferin results in decreased more ...CTDPMID:24859013
Nfe2l2Rat(+)-alpha-viniferin affects response to substanceISORGD:7344326480464NFE2L2 protein affects the susceptibility to alpha-viniferinCTDPMID:24859013
Nfe2l2Rat(+)-beta-thujone multiple interactionsISORGD:7344316480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated more ...CTDPMID:38000518
Nfe2l2Rat(+)-catechin increases expressionISORGD:7344316480464Catechin results in increased expression of NFE2L2 proteinCTDPMID:16799064
Nfe2l2Rat(+)-epicatechin-3-O-gallate multiple interactionsISORGD:7344316480464[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ...CTDPMID:29061316
Nfe2l2Rat(+)-isoborneol multiple interactionsISORGD:7344326480464isoborneol inhibits the reaction [Ceruletide results in decreased expression of NFE2L2 protein]CTDPMID:33166053
Nfe2l2Rat(+)-pilocarpine increases expressionISORGD:7344316480464Pilocarpine results in increased expression of NFE2L2 proteinCTDPMID:32234387
Nfe2l2Rat(+)-schisandrin B affects localizationISORGD:7344326480464schizandrin B affects the localization of NFE2L2 proteinCTDPMID:21250784
Nfe2l2Rat(+)-schisandrin B multiple interactionsISORGD:7344316480464[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NFE2L2 mRNA; [Benzo(a)pyrene co-treated with more ...CTDPMID:25946486
Nfe2l2Rat(+)-taxifolin increases expressionISORGD:7344316480464taxifolin results in increased expression of NFE2L2 proteinCTDPMID:16799064
Nfe2l2Rat(+)-taxifolin multiple interactionsEXP 6480464alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in more ...CTDPMID:33840231|PMID:33882723|PMID:35465754
Nfe2l2Rat(+)-taxifolin multiple interactionsISORGD:7344326480464Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]CTDPMID:31152760
Nfe2l2Rat(+)-taxifolin decreases expressionISORGD:7344326480464taxifolin results in decreased expression of NFE2L2 proteinCTDPMID:31152760
Nfe2l2Rat(+)-trans-(S)-allethrin increases expressionISORGD:7344316480464bioallethrin results in increased expression of NFE2L2 proteinCTDPMID:35511042
Nfe2l2Rat(+)-trans-(S)-allethrin multiple interactionsISORGD:7344316480464Vitamin E inhibits the reaction [bioallethrin results in increased expression of NFE2L2 protein]CTDPMID:35511042
Nfe2l2Rat(-)-ephedrine multiple interactionsISORGD:7344316480464Ephedrine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]CTDPMID:37778983
Nfe2l2Rat(-)-epigallocatechin 3-gallate increases expressionISORGD:7344316480464epigallocatechin gallate results in increased expression of NFE2L2 mRNA; epigallocatechin gallate results in increased expression more ...CTDPMID:16799064|PMID:29572906
Nfe2l2Rat(-)-epigallocatechin 3-gallate decreases expressionISORGD:7344316480464epigallocatechin gallate results in decreased expression of NFE2L2 proteinCTDPMID:35218280
Nfe2l2Rat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:7344326480464[[sodium arsenite results in increased abundance of Arsenic] which co-treated with epigallocatechin gallate] results in more ...CTDPMID:30395894|PMID:33410021|PMID:37286014

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Biological Process
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Nfe2l2Rataflatoxin catabolic process  IMP 12910550 RGD 
Nfe2l2Ratcell redox homeostasis involved_inISORGD:7344311624291 PMID:29018201RGDPMID:29018201
Nfe2l2Ratcell redox homeostasis involved_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcell redox homeostasis involved_inIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcell redox homeostasis involved_inISSUniProtKB:Q162361600115GO_REF:0000024UniProtGO_REF:0000024
Nfe2l2Ratcell redox homeostasis involved_inIMP 8655528PMID:16314513UniProt 
Nfe2l2Ratcell redox homeostasis involved_inISORGD:7344321624291 PMID:14978030RGDPMID:14978030
Nfe2l2Ratcellular response to angiotensin  IDA 11344212 RGD 
Nfe2l2Ratcellular response to copper ion acts_upstream_of_or_withinISORGD:7344321624291MGI:2385925 PMID:24462598RGDPMID:24462598
Nfe2l2Ratcellular response to copper ion acts_upstream_of_or_withinIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcellular response to fluid shear stress involved_inISSUniProtKB:Q162361600115GO_REF:0000024UniProtGO_REF:0000024
Nfe2l2Ratcellular response to fluid shear stress involved_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcellular response to fluid shear stress involved_inISORGD:7344311624291 PMID:25190803RGDPMID:25190803
Nfe2l2Ratcellular response to glucose starvation involved_inISORGD:7344321624291 PMID:14978030RGDPMID:14978030
Nfe2l2Ratcellular response to glucose starvation involved_inIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcellular response to hydrogen peroxide involved_inISORGD:7344311624291UniProtKB:Q99497 PMID:22492997, PMID:23043106RGDPMID:22492997|PMID:23043106
Nfe2l2Ratcellular response to hydrogen peroxide involved_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcellular response to hypoxia  IEP 10412703 RGD 
Nfe2l2Ratcellular response to hypoxia involved_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcellular response to hypoxia involved_inISORGD:7344311624291 PMID:24844779RGDPMID:24844779
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Cellular Component
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Nfe2l2Ratcentrosome located_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcentrosome located_inISORGD:734431|UniProtKB:Q16236-1|UniProtKB:Q16236-2|UniProtKB:Q16236-31624291 RGDGO_REF:0000052
Nfe2l2Ratchromatin located_inISORGD:7344321624291 PMID:20978343RGDPMID:20978343
Nfe2l2Ratchromatin located_inIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratciliary basal body located_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratciliary basal body located_inISORGD:734431|UniProtKB:Q16236-1|UniProtKB:Q16236-2|UniProtKB:Q16236-31624291 RGDGO_REF:0000052
Nfe2l2Ratcytoplasm located_inISORGD:7344311624291 PMID:15601839, PMID:22492997RGDPMID:15601839|PMID:22492997
Nfe2l2Ratcytoplasm located_inIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Nfe2l2Ratcytoplasm located_inISORGD:7344321624291PR:Q9Z2X8 PMID:14517290, PMID:14978030, PMID:15367669, PMID:17903176, PMID:17920186, PMID:20978343RGDPMID:14517290|PMID:14978030|PMID:15367669|PMID:17903176|PMID:17920186|PMID:20978343
Nfe2l2Ratcytoplasm located_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcytosol located_inISORGD:7344321624291 PMID:23043106RGDPMID:23043106
Nfe2l2Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Nfe2l2Ratcytosol located_inTAS 1600115Reactome:R-RNO-8932373ReactomeReactome:R-RNO-8932373
Nfe2l2Ratcytosol located_inIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcytosol located_inISORGD:734431|UniProtKB:Q16236-1|UniProtKB:Q16236-2|UniProtKB:Q16236-31624291 RGDGO_REF:0000052
Nfe2l2Ratcytosol located_inIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2Ratcytosol located_inISORGD:7344311624291 PMID:23043106RGDPMID:23043106
Nfe2l2Ratcytosol is_active_inISORGD:7344321624291uniprotkb:Q6PFY1 PMID:34168078RGDPMID:34168078
Nfe2l2RatGolgi apparatus located_inISORGD:734431|UniProtKB:Q16236-1|UniProtKB:Q16236-2|UniProtKB:Q16236-31624291 RGDGO_REF:0000052
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Molecular Function
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Nfe2l2RatDNA binding enablesISORGD:7344311624291 PMID:18554677RGDPMID:18554677
Nfe2l2RatDNA binding enablesIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA binding enablesISORGD:7344321624291 PMID:12220541, PMID:14517290, PMID:15870285RGDPMID:12220541|PMID:14517290|PMID:15870285
Nfe2l2RatDNA binding enablesIEAInterPro:IPR004826|InterPro:IPR0089171600115GO_REF:0000002InterProGO_REF:0000002
Nfe2l2RatDNA binding enablesIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nfe2l2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISORGD:7344321624291 PMID:10037736RGDPMID:10037736
Nfe2l2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISORGD:7344311624291 PMID:17015834, PMID:22492997RGDPMID:17015834|PMID:22492997
Nfe2l2RatDNA-binding transcription factor activity enablesIEAInterPro:IPR004827|InterPro:IPR046347|InterPro:IPR0471671600115GO_REF:0000002InterProGO_REF:0000002
Nfe2l2RatDNA-binding transcription factor activity enablesIEAUniProtKB:Q60795|ensembl:ENSMUSP000000997331600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA-binding transcription factor activity enablesIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
Nfe2l2RatDNA-binding transcription factor activity enablesISORGD:7344321624291 PMID:12220541, PMID:14517290, PMID:9240432RGDPMID:12220541|PMID:14517290|PMID:9240432
Nfe2l2RatDNA-binding transcription factor activity enablesISORGD:7344311624291 PMID:20452972RGDPMID:20452972
Nfe2l2RatDNA-binding transcription factor activity enablesISSUniProtKB:Q162361600115GO_REF:0000024UniProtGO_REF:0000024
Nfe2l2RatDNA-binding transcription factor activity enablesISSUniProtKB:Q607951600115GO_REF:0000024UniProtGO_REF:0000024
Nfe2l2RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0262975|MGI:108420|MGI:1339958|MGI:99421|PANTHER:PTN002399572|UniProtKB:Q14494|UniProtKB:Q162361600115GO_REF:0000033GO_CentralGO_REF:0000033
Nfe2l2Ratmolecular condensate scaffold activity enablesISORGD:7344311624291 PMID:32727915RGDPMID:32727915
Nfe2l2Ratmolecular condensate scaffold activity enablesIEAUniProtKB:Q16236|ensembl:ENSP000003802521600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Nfe2l2Ratnuclear factor, erythroid 2 like 2 signaling pathway   ISORGD:73443111530066 RGD 
Nfe2l2Ratnuclear factor, erythroid 2 like 2 signaling pathway   ISORGD:73443111535070 RGD 
Nfe2l2Ratnuclear factor, erythroid 2 like 2 signaling pathway   ISORGD:73443111535066 RGD 
Nfe2l2Ratoxidative stress response pathway  IDA 15090820 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfe2l2RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfe2l2Ratabnormal incisor color  IMP 12910550 RGD 
Nfe2l2Ratabnormal vasodilation  IMP 11344212 RGD 
Nfe2l2Ratdecreased vasodilation  IMPXCO:0000143, XCO:0000191, XCO:000079511344212compared to SDRGD 
Nfe2l2Ratincreased susceptibility to xenobiotic induced morbidity/mortality  IMPCHEBI:250412910550 RGD 
Nfe2l2Ratsmall liver  IMP 12910550 RGD 

1 to 20 of 100 rows
#
Reference Title
Reference Citation
1. Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity. Abdelzaher WY, etal., Immunopharmacol Immunotoxicol. 2020 Feb 18:1-9. doi: 10.1080/08923973.2020.1727499.
2. The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway. Abo El-Magd NF and Eraky SM, Life Sci. 2020 Mar 1;244:117331. doi: 10.1016/j.lfs.2020.117331. Epub 2020 Jan 20.
3. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. Acar N, etal., Acta Histochem. 2014 Oct;116(8):1289-300. doi: 10.1016/j.acthis.2014.07.012. Epub 2014 Aug 27.
4. Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy. Aminzadeh MA, etal., Nephrol Dial Transplant. 2013 Aug;28(8):2038-45. doi: 10.1093/ndt/gft022. Epub 2013 Mar 19.
5. Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. Arambasic J, etal., Eur J Nutr. 2013 Aug;52(5):1461-73. doi: 10.1007/s00394-012-0452-z. Epub 2012 Oct 12.
6. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Arredondo F, etal., Free Radic Biol Med. 2010 Sep 1;49(5):738-47. doi: 10.1016/j.freeradbiomed.2010.05.020. Epub 2010 Jun 8.
7. Reduction of hippocampal apoptosis by intracerebroventricular administration of extracellular signal-regulated protein kinase and/or p38 inhibitors in amyloid beta rat model of Alzheimer's disease: involvement of nuclear-related factor-2 and nuclear factor-kappaB. Ashabi G, etal., Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):145-55. doi: 10.1111/bcpt.12000. Epub 2012 Oct 5.
8. Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Ashino T, etal., Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):760-8. doi: 10.1161/ATVBAHA.112.300614. Epub 2013 Feb 14.
9. Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance. Azzimato V, etal., Sci Transl Med. 2020 Feb 26;12(532). pii: 12/532/eaaw9709. doi: 10.1126/scitranslmed.aaw9709.
10. Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation. Bai Y, etal., J Mol Cell Cardiol. 2013 Apr;57:82-95. doi: 10.1016/j.yjmcc.2013.01.008. Epub 2013 Jan 23.
11. Association between genetic polymorphisms of NRF2, KEAP1, MAFF, MAFK and anti-tuberculosis drug-induced liver injury: a nested case-control study. Chen S, etal., Sci Rep. 2019 Oct 4;9(1):14311. doi: 10.1038/s41598-019-50706-y.
12. Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Cheon HJ, etal., Chem Biol Interact. 2018 Oct 1;294:74-80. doi: 10.1016/j.cbi.2018.08.022. Epub 2018 Aug 22.
13. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
14. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Cui G, etal., Int J Cardiol. 2013 Sep 30;168(2):1349-59. doi: 10.1016/j.ijcard.2012.12.012. Epub 2013 Jan 4.
15. Effectiveness of miltefosine treatment in targeting anti-leishmanial HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis patients. Das S, etal., J Antimicrob Chemother. 2013 Sep;68(9):2059-65. doi: 10.1093/jac/dkt162. Epub 2013 May 31.
16. DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis. Feng X, etal., Neuropharmacology. 2012 Feb;62(2):1004-10. doi: 10.1016/j.neuropharm.2011.10.009. Epub 2011 Nov 2.
17. Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2. Fitzpatrick AM, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1604-11. Epub 2011 Apr 22.
18. Activation of the nuclear factor erythroid 2-related factor 2-antioxidant response element signal in rats with diffuse axonal injury. Gao P, etal., Neuroreport. 2019 Apr 10;30(6):389-396. doi: 10.1097/WNR.0000000000001210.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
1 to 20 of 100 rows
1 to 10 of 36 rows
PMID:9240432   PMID:10037736   PMID:11256947   PMID:12220541   PMID:12682069   PMID:14517290   PMID:14978030   PMID:15087497   PMID:15367669   PMID:15574414   PMID:15582588   PMID:15601839  
PMID:15870071   PMID:15983046   PMID:15988009   PMID:16000310   PMID:16374848   PMID:16758951   PMID:16962933   PMID:17015834   PMID:17038627   PMID:17083329   PMID:17394461   PMID:17468336  
PMID:17681938   PMID:17881530   PMID:17903176   PMID:17920186   PMID:17962605   PMID:18081878   PMID:18202225   PMID:18355458   PMID:18554677   PMID:18617559   PMID:18844975   PMID:19351736  
PMID:19424503   PMID:19445907   PMID:19459163   PMID:19484125   PMID:19490425   PMID:20007347   PMID:20026152   PMID:20137388   PMID:20210857   PMID:20384467   PMID:20433640   PMID:20447451  
PMID:20452972   PMID:20498371   PMID:20518088   PMID:20594978   PMID:20689134   PMID:20855618   PMID:20978266   PMID:20978343   PMID:21141598   PMID:21193948   PMID:21259333   PMID:21295052  
PMID:21304811   PMID:21384399   PMID:21398409   PMID:21602469   PMID:21645446   PMID:21703357   PMID:21806470   PMID:21873460   PMID:21878664   PMID:21899994   PMID:21908547   PMID:21932039  
PMID:21964506   PMID:22031657   PMID:22212472   PMID:22355716   PMID:22472608   PMID:22492997   PMID:22537865   PMID:22705828   PMID:22730684   PMID:22806321   PMID:22964297   PMID:23036869  
PMID:23043106   PMID:23044235   PMID:23056222   PMID:23209658   PMID:23223967   PMID:23306837   PMID:23434824   PMID:23454680   PMID:23523995   PMID:23537652   PMID:23554160   PMID:23566817  
PMID:23635713   PMID:23684718   PMID:23690560   PMID:23697596   PMID:23722164   PMID:23748533   PMID:23770986   PMID:23826208   PMID:23902943   PMID:23963778   PMID:24010821   PMID:24024172  
PMID:24055888   PMID:24145448   PMID:24191235   PMID:24219386   PMID:24346829   PMID:24363993   PMID:24379627   PMID:24417315   PMID:24462598   PMID:24464634   PMID:24486487   PMID:24500986  
1 to 10 of 36 rows



Nfe2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,001,529 - 81,031,165 (-)NCBIGRCr8
mRatBN7.2360,594,239 - 60,621,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,968,507 - 63,995,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,552,163 - 72,579,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,318,419 - 70,345,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
NFE2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382177,230,303 - 177,264,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2177,218,667 - 177,392,756 (-)EnsemblGRCh38hg38GRCh38
GRCh372178,095,031 - 178,129,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362177,803,282 - 177,837,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 342177,920,542 - 177,954,924NCBI
Celera2171,697,459 - 171,732,295 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2169,966,324 - 170,001,125 (-)NCBIHuRef
CHM1_12178,100,863 - 178,135,685 (-)NCBICHM1_1
T2T-CHM13v2.02177,712,539 - 177,746,971 (-)NCBIT2T-CHM13v2.0
Nfe2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39275,505,860 - 75,535,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl275,505,857 - 75,534,985 (-)EnsemblGRCm39 Ensembl
GRCm38275,675,513 - 75,704,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl275,675,513 - 75,704,641 (-)EnsemblGRCm38mm10GRCm38
MGSCv37275,513,576 - 75,542,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36275,476,358 - 75,505,480 (-)NCBIMGSCv36mm8
Celera277,336,615 - 77,365,680 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.75NCBI
Nfe2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBIChiLan1.0ChiLan1.0
NFE2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21379,896,932 - 80,058,685 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B79,911,905 - 80,073,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B64,509,446 - 64,544,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B182,214,116 - 182,248,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B182,214,116 - 182,248,085 (-)Ensemblpanpan1.1panPan2
NFE2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13620,989,205 - 21,087,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3620,989,360 - 21,012,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3621,008,912 - 21,151,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03621,133,291 - 21,275,953 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3621,133,296 - 21,276,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13621,203,925 - 21,237,606 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03621,205,089 - 21,302,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03621,320,865 - 21,418,596 (-)NCBIUU_Cfam_GSD_1.0
Nfe2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303138,036,230 - 138,177,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365096,590,630 - 6,620,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365096,589,967 - 6,621,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFE2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1582,973,656 - 83,146,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11582,967,485 - 83,146,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21592,433,294 - 92,469,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFE2L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11062,789,647 - 62,825,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040136,640,202 - 136,820,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfe2l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478714,355,791 - 14,381,251 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478714,355,330 - 14,381,353 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Nfe2l2
96 total Variants

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:158
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000002114
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat

1 to 10 of 54 rows
RH130653  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,597,065 - 60,597,248 (+)MAPPERmRatBN7.2
Rnor_6.0362,500,392 - 62,500,574NCBIRnor6.0
Rnor_5.0369,044,468 - 69,044,650UniSTSRnor5.0
RGSC_v3.4358,369,514 - 58,369,696UniSTSRGSC3.4
Celera360,097,862 - 60,098,044UniSTS
Cytogenetic Map3q23UniSTS
BI284301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,594,712 - 60,594,869 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,039 - 62,498,195NCBIRnor6.0
Rnor_5.0369,042,115 - 69,042,271UniSTSRnor5.0
RGSC_v3.4358,367,161 - 58,367,317UniSTSRGSC3.4
Celera360,095,509 - 60,095,665UniSTS
Cytogenetic Map3q23UniSTS
RH135926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,594,910 - 60,595,115 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,237 - 62,498,441NCBIRnor6.0
Rnor_5.0369,042,313 - 69,042,517UniSTSRnor5.0
RGSC_v3.4358,367,359 - 58,367,563UniSTSRGSC3.4
Celera360,095,707 - 60,095,911UniSTS
Cytogenetic Map3q23UniSTS
Nfe2l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,595,122 - 60,596,303 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,449 - 62,499,629NCBIRnor6.0
Rnor_5.0369,042,525 - 69,043,705UniSTSRnor5.0
RGSC_v3.4358,367,571 - 58,368,751UniSTSRGSC3.4
Celera360,095,919 - 60,097,099UniSTS
Cytogenetic Map3q23UniSTS


This gene Nfe2l2 is modified in the following models/strains:
SD-Nfe2l2em1Mcwi     SD-Nfe2l2em1Mcwi-/-     F344-Nfe2l2em2Kyo     F344-Nfe2l2em1Kyo    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 18 of 18 rows
RefSeq Transcripts NM_001399173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF037350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSRNOT00000002114   ⟹   ENSRNOP00000002114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)Ensembl
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104413   ⟹   ENSRNOP00000087804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,605,874 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110389   ⟹   ENSRNOP00000097870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,598,646 (-)Ensembl
RefSeq Acc Id: NM_001399173   ⟹   NP_001386102
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,529 - 81,028,999 (-)NCBI
mRatBN7.2360,594,239 - 60,621,712 (-)NCBI
RefSeq Acc Id: NM_031789   ⟹   NP_113977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,529 - 81,028,999 (-)NCBI
mRatBN7.2360,594,239 - 60,621,712 (-)NCBI
Rnor_6.0362,497,571 - 62,524,994 (-)NCBI
Rnor_5.0369,041,641 - 69,069,190 (-)NCBI
RGSC_v3.4358,366,693 - 58,394,116 (-)RGD
Celera360,095,041 - 60,122,464 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234398   ⟹   XP_006234460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,028,809 (-)NCBI
mRatBN7.2360,594,239 - 60,621,528 (-)NCBI
Rnor_6.0362,497,568 - 62,524,157 (-)NCBI
Rnor_5.0369,041,641 - 69,069,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284651   ⟹   XP_063140721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,031,165 (-)NCBI
RefSeq Acc Id: XM_063284652   ⟹   XP_063140722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,031,165 (-)NCBI
RefSeq Acc Id: XM_063284653   ⟹   XP_063140723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,028,813 (-)NCBI
RefSeq Acc Id: NP_113977   ⟸   NM_031789
- Peptide Label: isoform 2
- UniProtKB: A6HMF7 (UniProtKB/TrEMBL),   A0A8I6AV20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234460   ⟸   XM_006234398
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7Z8 (UniProtKB/TrEMBL),   A6HMG0 (UniProtKB/TrEMBL),   A0A8I6AV20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002114   ⟸   ENSRNOT00000002114
Ensembl Acc Id: ENSRNOP00000087804   ⟸   ENSRNOT00000104413
Ensembl Acc Id: ENSRNOP00000097870   ⟸   ENSRNOT00000110389
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-O54968-F1-model_v2 AlphaFold O54968 1-604 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692153
Promoter ID:EPDNEW_R2678
Type:initiation region
Name:Nfe2l2_1
Description:nuclear factor, erythroid 2-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0362,525,015 - 62,525,075EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49302 BioCyc
Ensembl Genes ENSRNOG00000001548 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002114 ENTREZGENE
  ENSRNOT00000002114.7 UniProtKB/Swiss-Prot
Gene3D-CATH Transcription factor, Skn-1-like, DNA-binding domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598313 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_Maf UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  NFE2-like UniProtKB/Swiss-Prot
  TF_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:83619 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72386 IMAGE-MGC_LOAD
NCBI Gene 83619 ENTREZGENE
PANTHER NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR UniProtKB/Swiss-Prot
  PTHR24411:SF3 UniProtKB/Swiss-Prot
Pfam bZIP_Maf UniProtKB/Swiss-Prot
PhenoGen Nfe2l2 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001548 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A0A8I6A7Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV20 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF7 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF8 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF9 ENTREZGENE, UniProtKB/TrEMBL
  A6HMG0 ENTREZGENE, UniProtKB/TrEMBL
  NF2L2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7C8 ENTREZGENE
UniProt Secondary Q6P7C8 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Nfe2l2  nuclear factor, erythroid 2-like 2  Nfe2l2  nuclear factor, erythroid derived 2, like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nfe2l2  nuclear factor, erythroid derived 2, like 2    NF-E2-related factor 2  Name updated 1299863 APPROVED
2002-08-07 Nfe2l2  NF-E2-related factor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation phosphorylated on Ser-40 by protein kinase C resulting in translocation to nucleus 729231
gene_regulation translocation to the nucleus is controled by PI3-kinase signaling pathway which regulates rearrangement of actin microfilaments in response to oxidative stress 727460