Strain Report - Rat Genome Database

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Strain: SD-Nfe2l2em1Mcwi-/-

Symbol: SD-Nfe2l2em1Mcwi-/-
Strain: SD-Nfe2l2em1-/Nfe2l2em1-
Substrain: Mcwi
Full Name: SD-Nfe2l2em1Mcwi-/Nfe2l2em1Mcwi-
RGD ID: 13208518
Citation ID: RRID:RGD_13208518
Ontology ID: RS:0004501
Alleles: Nfe2l2em1Mcwi
Previously known as: Nrf2-/-; SD-Nfe2l2em1Mcwi-/-
Type: mutant
Source: PhysGen Knockouts
Origin: This strain was produced by injecting TALENs targeting the sequence TAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAGGGCGGACGCTGCGCTA into Crl:SD Sprague Dawley rat embryos. The resulting mutation is a 41-bp deletion in exon 1.Founders were backcrossed with Crl:SD to get heterozygous offspring which were intercrossed and offspring maintained as homozygous and heterozygous breeders.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-08-09)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,594,239 - 60,621,785RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0362,497,568 - 62,525,146RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0369,041,641 - 69,069,190RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4358,366,693 - 58,394,116RGD_MAPPER_PIPELINERGSC3.4

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Priestley JR, etal., Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nfe2l2em1Mcwi-var1 chr3 60621570 60621610 TGTAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAG - deletion mRatBN7.2
Nfe2l2em1Mcwi-var1 chr3 62524893 62524933 TGTAGTCCTGGCGGTGGCAATTCCAAGTCCATCATGCTGAG - deletion Rnor_6.0

Additional Information