NFE2L2 (NFE2 like bZIP transcription factor 2) - Rat Genome Database

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Gene: NFE2L2 (NFE2 like bZIP transcription factor 2) Chlorocebus sabaeus
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Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
RGD ID: 18411184
Description: ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); transcription coregulator binding (ortholog); INVOLVED IN aflatoxin catabolic process (ortholog); cellular response to angiotensin (ortholog); cellular response to copper ion (ortholog); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; ASSOCIATED WITH Acidoses (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytosol (ortholog); mediator complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2 like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11062,789,647 - 62,825,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040136,640,202 - 136,820,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acidoses  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiac Fibrosis  (ISO)
Cardiac Output, Low  (ISO)
Cardiomegaly  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
colorectal cancer  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Endometrial Neoplasms  (ISO)
Endotoxemia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
gastrointestinal system disease  (ISO)
genital herpes  (ISO)
glucose intolerance  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA  (ISO)
Insulin Resistance  (ISO)
keratosis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
pancreatic ductal carcinoma  (ISO)
pleurisy  (ISO)
Premature Aging  (ISO)
primary biliary cholangitis  (ISO)
primary ovarian insufficiency  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
sickle cell anemia  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
split hand-foot malformation 5  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sunburn  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (ISO)
tuberculosis  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular System Injuries  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin catabolic process  (ISO)
cell redox homeostasis  (IEA)
cellular response to angiotensin  (ISO)
cellular response to copper ion  (IEA,ISO)
cellular response to fluid shear stress  (IEA)
cellular response to glucose starvation  (IEA)
cellular response to hydrogen peroxide  (IEA)
cellular response to hypoxia  (IEA,ISO)
cellular response to laminar fluid shear stress  (IEA)
cellular response to methionine  (ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
endoplasmic reticulum unfolded protein response  (IEA,ISO)
inflammatory response  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of ferroptosis  (IEA)
negative regulation of hematopoietic stem cell differentiation  (IEA)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
PERK-mediated unfolded protein response  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (IEA)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of D-glucose import  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glutathione biosynthetic process  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proteasomal ubiquitin-independent protein catabolic process  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein ubiquitination  (IEA)
reactive oxygen species metabolic process  (IEA,ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of embryonic development  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of innate immune response  (IEA)
regulation of primary metabolic process  (IEA)
regulation of removal of superoxide radicals  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to endoplasmic reticulum stress  (IEA)
response to ischemia  (ISO)
response to oxidative stress  (IEA)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NFE2L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11062,789,647 - 62,825,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040136,640,202 - 136,820,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NFE2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382177,230,303 - 177,264,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2177,218,667 - 177,392,756 (-)EnsemblGRCh38hg38GRCh38
GRCh372178,095,031 - 178,129,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362177,803,282 - 177,837,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 342177,920,542 - 177,954,924NCBI
Celera2171,697,459 - 171,732,295 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2169,966,324 - 170,001,125 (-)NCBIHuRef
CHM1_12178,100,863 - 178,135,685 (-)NCBICHM1_1
T2T-CHM13v2.02177,712,539 - 177,746,971 (-)NCBIT2T-CHM13v2.0
Nfe2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39275,505,860 - 75,535,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl275,505,857 - 75,534,985 (-)EnsemblGRCm39 Ensembl
GRCm38275,675,513 - 75,704,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl275,675,513 - 75,704,641 (-)EnsemblGRCm38mm10GRCm38
MGSCv37275,513,576 - 75,542,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36275,476,358 - 75,505,480 (-)NCBIMGSCv36mm8
Celera277,336,615 - 77,365,680 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.75NCBI
Nfe2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,001,529 - 81,031,165 (-)NCBIGRCr8
mRatBN7.2360,594,239 - 60,621,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,968,507 - 63,995,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,552,163 - 72,579,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,318,419 - 70,345,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
Nfe2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBIChiLan1.0ChiLan1.0
NFE2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21379,896,932 - 80,058,685 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B79,911,905 - 80,073,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B64,509,446 - 64,544,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B182,214,116 - 182,248,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B182,214,116 - 182,248,085 (-)Ensemblpanpan1.1panPan2
NFE2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13620,989,205 - 21,087,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3620,989,360 - 21,012,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3621,008,912 - 21,151,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03621,133,291 - 21,275,953 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3621,133,296 - 21,276,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13621,203,925 - 21,237,606 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03621,205,089 - 21,302,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03621,320,865 - 21,418,596 (-)NCBIUU_Cfam_GSD_1.0
Nfe2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303138,036,230 - 138,177,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365096,590,630 - 6,620,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365096,589,967 - 6,621,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFE2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1582,973,656 - 83,146,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11582,967,485 - 83,146,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21592,433,294 - 92,469,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nfe2l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478714,355,791 - 14,381,251 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478714,355,330 - 14,381,353 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000012447   ⟹   ENSCSAP00000010484
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)Ensembl
RefSeq Acc Id: XM_007965441   ⟹   XP_007963632
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11062,789,647 - 62,825,651 (-)NCBI
Vero_WHO_p1.0NW_023666040136,784,407 - 136,820,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007965442   ⟹   XP_007963633
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11062,789,647 - 62,824,822 (-)NCBI
Vero_WHO_p1.0NW_023666040136,785,788 - 136,820,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038000639   ⟹   XP_037856567
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040136,640,202 - 136,820,663 (+)NCBI
RefSeq Acc Id: XM_038000640   ⟹   XP_037856568
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040136,806,686 - 136,820,663 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007963632 (Get FASTA)   NCBI Sequence Viewer  
  XP_007963633 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856567 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010484
  ENSCSAP00000010484.1
RefSeq Acc Id: XP_007963632   ⟸   XM_007965441
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RPE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007963633   ⟸   XM_007965442
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000010484   ⟸   ENSCSAT00000012447
RefSeq Acc Id: XP_037856567   ⟸   XM_038000639
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037856568   ⟸   XM_038000640
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014353 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012447.1 UniProtKB/TrEMBL
Gene3D-CATH Transcription factor, Skn-1-like, DNA-binding domain UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_Maf UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  NFE2-like UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report csab:103217393 UniProtKB/TrEMBL
NCBI Gene NFE2L2 ENTREZGENE
PANTHER NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR UniProtKB/TrEMBL
  PTHR24411:SF3 UniProtKB/TrEMBL
Pfam bZIP_Maf UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/TrEMBL
  SSF57959 UniProtKB/TrEMBL
UniProt A0A0D9RPE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-05 NFE2L2  NFE2 like bZIP transcription factor 2  NFE2L2  nuclear factor, erythroid 2 like 2  Symbol and/or name change 5135510 APPROVED