RGD Reference Report - Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect? - Rat Genome Database

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Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?

Authors: Li, B  Wang, L  Lu, Q  Da, W 
Citation: Li B, etal., Ir J Med Sci. 2016 Feb;185(1):93-100. doi: 10.1007/s11845-014-1226-9. Epub 2014 Nov 11.
RGD ID: 21201312
Pubmed: PMID:25385666   (View Abstract at PubMed)
DOI: DOI:10.1007/s11845-014-1226-9   (Journal Full-text)


AIM: Nuclear factor-erythroid 2-related factor-2 (Nrf2) acts as a defense system in the development of nonalcoholic steatohepatitis (NASH). Curcumin is a phenolic compound with lipid regulatory, anti-oxidative, anti-inflammatory and anti-tumorigenic properties that is beneficial in defending against NASH and was recently proved to be an Nrf2 activator. The aim of this study was to evaluate whether Nrf2 activation could be involved in NASH mitigation by curcumin.
METHODS: Hepatic, metabolic, and inflammatory parameters, along with hepatic Nrf2 protein expression were explored in adult Sprague-Dawley rats developing high-fat-diet-induced NASH and submitted to curcumin gavage for 6 weeks.
RESULTS: Curcumin administration led to lower degrees of hepatic steatosis and inflammation; lower levels of serum aminotransferases, lipids, and homeostasis model assessment of insulin resistance; and lower serum and hepatic contents of tumor necrosis factor-α (TNF-α), interleukin-6, and malondialdehyde. In contrast, higher hepatic contents of glutathione, heme oxygenase-1 and superoxide dismutase were observed in rats with curcumin. Moreover, Nrf2 expression in liver cell nuclei was significantly higher in rats with curcumin.
CONCLUSIONS: Curcumin can prevent and ameliorate NASH via lipid reduction, improve insulin resistance, improve anti-inflammatory, and have antioxidant effects, possibly related to its activation of Nrf2.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
metabolic dysfunction-associated steatohepatitis treatmentISONfe2l2 (Rattus norvegicus)21201312; 21201312 RGD 
metabolic dysfunction-associated steatohepatitis treatmentIEP 21201312 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nfe2l2  (NFE2 like bZIP transcription factor 2)

Genes (Mus musculus)
Nfe2l2  (nuclear factor, erythroid derived 2, like 2)

Genes (Homo sapiens)
NFE2L2  (NFE2 like bZIP transcription factor 2)


Additional Information