Nfe2l2<sup>em1Kyo</sup> (nuclear factor, erythroid 2-like 2; zinc finger nuclease induced mutant 1, Kyoto University) - Rat Genome Database

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Gene: Nfe2l2em1Kyo (nuclear factor, erythroid 2-like 2; zinc finger nuclease induced mutant 1, Kyoto University) Rattus norvegicus
Analyze
Symbol: Nfe2l2em1Kyo
Name: nuclear factor, erythroid 2-like 2; zinc finger nuclease induced mutant 1, Kyoto University
RGD ID: 10045594
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 7-bp deletion in exon 5 of Nrf2 (ACCACTGTCCCCAGCCCAgaggccACACTGACAGAGATGGAC)
ASSOCIATED WITH abnormal incisor color; increased susceptibility to xenobiotic induced morbidity/mortality; small liver
Type: allele  of Nfe2l2  
Previously known as: Nfe2l2^[em1Kyo]; Nfe2l2em1Kyo
Is Marker For: Strains:   F344-Nfe2l2em1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map3 RGD


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Taguchi K, etal., Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nfe2l2em1Kyo-var1 chr3 60595852 60595858 TGGCCTC - deletion mRatBN7.2
Nfe2l2em1Kyo-var1 chr3 62499178 62499184 TGGCCTC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Nfe2l2em1Kyo
F344-Nfe2l2em1Kyo    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information