Rhoa (ras homolog family member A) - Rat Genome Database

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Gene: Rhoa (ras homolog family member A) Rattus norvegicus
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Symbol: Rhoa
Name: ras homolog family member A
RGD ID: 619921
Description: Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including intracellular signal transduction; regulation of neuron projection development; and regulation of synapse organization. Acts upstream of or within negative regulation of vascular associated smooth muscle cell migration and negative regulation of vascular associated smooth muscle cell proliferation. Located in several cellular components, including axon; dendritic spine; and neuronal cell body. Used to study membranous glomerulonephritis. Biomarker of artery disease (multiple); asthma; fetal alcohol syndrome; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; INTERACTS WITH (S)-(-)-perillyl alcohol; 1-octadec-9-enoylglycero-3-phosphate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Arha; Arha2; MGC72339; plysia ras-related homolog A2; ras homolog gene family, member A; transforming protein RhoA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,870,548 - 117,904,303 (+)NCBIGRCr8
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,643,315 - 114,651,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,842,642 - 112,851,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,685,281 - 110,693,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
acute myocardial infarction  (IEP)
Aicardi-Goutieres Syndrome 1  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
ectodermal dysplasia  (ISO)
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
fetal alcohol syndrome  (IEP)
Fibrosis  (IEP)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
glycine encephalopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (IEP)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (IMP)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
Optic Nerve Injuries  (IEP)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
Pierson syndrome  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (IEP)
Spinal Cord Injuries  (IEP)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-(-)-perillyl alcohol  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetylcholine  (EXP)
Aescin  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atropine  (ISO)
beclomethasone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brimonidine tartrate  (EXP)
bufalin  (ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (EXP)
Calpeptin  (ISO)
cannabidiol  (ISO)
carvone  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chloropicrin  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloastragenol  (EXP)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
Dimethylphosphate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dizocilpine maleate  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
everolimus  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (ISO)
fasudil  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flavonol  (ISO)
flubendazole  (ISO)
fluvastatin  (EXP,ISO)
folic acid  (ISO)
fucoxanthin  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (ISO)
geranylgeraniol  (EXP,ISO)
glucose  (EXP,ISO)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GTP  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
kanamycin A  (ISO)
KT 5823  (ISO)
latrunculin B  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP)
malathion  (ISO)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mevalonic acid  (EXP,ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
myrtenol  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nonanoic acid  (ISO)
oroxylin A  (EXP)
ozone  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perillic acid  (ISO)
perillyl alcohol  (EXP,ISO)
perillyl aldehyde  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 12,13-dibutanoate  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
prednisolone  (EXP)
progesterone  (EXP)
quercetin  (ISO)
quinpirole  (ISO)
raloxifene  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP,ISO)
Ro 31-8220  (EXP)
rotenone  (EXP,ISO)
Sanggenon C  (EXP)
scoparone  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
solasodine  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
terbinafine  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-piceid  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
Y-27632  (ISO)
zaragozic acid A  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO,ISS,TAS)
actin filament organization  (IBA)
alpha-beta T cell lineage commitment  (ISO)
androgen receptor signaling pathway  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
aortic valve formation  (IEA,ISO)
apical junction assembly  (IEA,ISO,ISS)
apolipoprotein A-I-mediated signaling pathway  (IEA,ISO)
beta selection  (ISO)
bone trabecula morphogenesis  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell junction assembly  (ISO,ISS)
cell migration  (IBA,ISO,ISS)
cell morphogenesis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to chemokine  (IEA,ISO,ISS)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to progesterone stimulus  (NAS)
cerebral cortex cell migration  (ISO)
cleavage furrow formation  (ISO,ISS)
cytoplasmic microtubule organization  (IEA,ISO)
cytoskeleton organization  (ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (IEA,ISO)
endothelial tube lumen extension  (IEA,ISO)
establishment of epithelial cell apical/basal polarity  (IEA,ISO,ISS)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
forebrain radial glial cell differentiation  (ISO)
GTP metabolic process  (IDA)
kidney development  (ISO)
meiotic spindle organization  (ISO)
microtubule depolymerization  (IMP)
mitotic cleavage furrow formation  (IEA,ISO,ISS)
mitotic cytokinesis  (IBA)
mitotic spindle assembly  (IEA,ISO)
motor neuron apoptotic process  (ISO)
negative chemotaxis  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IMP)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of cell size  (IEA,ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of motor neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (IMP)
negative regulation of neuron projection development  (IGI)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of synapse assembly  (IMP)
negative regulation of vascular associated smooth muscle cell migration  (IMP)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
neuron migration  (ISO)
neuron projection morphogenesis  (IEP)
odontogenesis  (ISO)
ossification involved in bone maturation  (ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (IMP)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of cell adhesion  (IEP)
positive regulation of cell growth  (IEP,IMP)
positive regulation of cell migration  (IEP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of cytokinesis  (IEA,ISO,ISS)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of T cell migration  (IEA,ISO,ISS)
positive regulation of translation  (IEP)
positive regulation of vascular associated smooth muscle contraction  (ISO)
positive regulation of vasoconstriction  (IEP)
regulation of actin cytoskeleton organization  (IBA,ISO)
regulation of actin polymerization or depolymerization  (IEP)
regulation of calcium ion transport  (IMP)
regulation of cell migration  (ISO,ISS)
regulation of dendrite development  (IMP)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of modification of postsynaptic actin cytoskeleton  (IEA,ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of modification of synaptic structure  (IMP)
regulation of neural precursor cell proliferation  (ISO)
regulation of neuron projection development  (ISO)
regulation of osteoblast proliferation  (ISO)
regulation of systemic arterial blood pressure by endothelin  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to amino acid  (IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP)
response to mechanical stimulus  (IEP)
response to xenobiotic stimulus  (IDA,IEP)
Rho protein signal transduction  (IBA,IDA,IEA,IMP,ISO,ISS)
Roundabout signaling pathway  (IEA,ISO,ISS)
semaphorin-plexin signaling pathway  (ISO)
signal transduction  (IBA)
skeletal muscle satellite cell migration  (ISS)
skeletal muscle tissue development  (ISO)
small GTPase-mediated signal transduction  (IEA)
spindle localization  (ISO)
stress fiber assembly  (IBA,IEA,ISO,ISS)
stress-activated protein kinase signaling cascade  (IMP)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
wound healing, spreading of cells  (ISS)

Cellular Component
apical junction complex  (IEA,ISO,ISS)
axon  (IDA)
cell cortex  (IEA,ISO,ISS)
cell periphery  (ISO)
cleavage furrow  (IBA,IEA,ISO,ISS)
cytoplasmic side of plasma membrane  (IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IBA,IDA,IEA,ISO)
dendrite  (IDA)
dendritic spine  (IBA,IDA,IEA,ISO)
endosome  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
lamellipodium  (IEA,ISO,ISS)
meiotic spindle  (ISO)
membrane  (IDA)
midbody  (IEA)
neuronal cell body  (IDA)
nucleus  (ISO)
plasma membrane  (IBA,ISO)
postsynapse  (ISO)
ruffle membrane  (ISO)
vesicle  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Appert-Collin A, etal., Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10140-5. Epub 2007 May 30.
3. Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Barman SA Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L472-9. Epub 2007 Apr 27.
4. RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Bellizzi A, etal., Int J Mol Med. 2008 Jul;22(1):25-31.
5. Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation. Bulhak A, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3158-63. Epub 2007 Feb 23.
6. RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels. Chen H and Firestein BL, J Neurosci. 2007 Aug 1;27(31):8378-86.
7. Activated RHOA and peripheral axon regeneration. Cheng C, etal., Exp Neurol. 2008 Aug;212(2):358-69. Epub 2008 Apr 30.
8. Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation of RhoA in rats. Chiba Y, etal., J Pharmacol Sci. 2008 Apr;106(4):615-25. Epub 2008 Apr 5.
9. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Chockalingam PS, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C500-11.
10. The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. Corteling RL, etal., Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H440-7. Epub 2007 Mar 16.
11. RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability. Da Silva JS, etal., J Cell Biol 2003 Sep 29;162(7):1267-79.
12. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. Dovas A, etal., J Biol Chem. 2010 Jul 23;285(30):23296-308. doi: 10.1074/jbc.M109.098129. Epub 2010 May 15.
13. CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion. Doye A, etal., Cell 2002 Nov 15;111(4):553-64.
14. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Fritz G, etal., Br J Cancer. 2002 Sep 9;87(6):635-44.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Guilluy C, etal., Br J Pharmacol. 2005 Dec;146(7):1010-8.
17. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. Hilgers RH, etal., J Hypertens. 2007 Aug;25(8):1687-97.
18. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. Homma N, etal., J Cardiovasc Pharmacol. 2007 Dec;50(6):697-702.
19. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Horiuchi A, etal., Lab Invest. 2003 Jun;83(6):861-70.
20. Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells. Hoshino M and Nakamura S, J Cell Biol. 2003 Dec 8;163(5):1067-76.
21. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
22. Regulation of T-type calcium channels by Rho-associated kinase. Iftinca M, etal., Nat Neurosci. 2007 Jul;10(7):854-60. Epub 2007 Jun 10.
23. Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. Joshi S, etal., Cell Mol Life Sci. 2006 Dec;63(23):2859-70.
24. RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer. Kamai T, etal., BJU Int 2003 Feb;91(3):234-8.
25. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. Kamai T, etal., BJU Int. 2002 Mar;89(4):449-53.
26. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Kamai T, etal., Clin Cancer Res. 2003 Jul;9(7):2632-41.
27. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Kamai T, etal., Clin Cancer Res. 2004 Jul 15;10(14):4799-805.
28. Rho-kinase as a molecular target for insulin resistance and hypertension. Kanda T, etal., FASEB J. 2006 Jan;20(1):169-71. Epub 2005 Nov 2.
29. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
30. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. Klussmann E, etal., FEBS Lett 2001 Nov 2;507(3):264-8.
31. Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Li Y, etal., Neuroreport. 2017 Jan 18;28(2):75-81. doi: 10.1097/WNR.0000000000000715.
32. Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. Martinez SE, etal., J Neurochem. 2007 Aug;102(4):1044-52. Epub 2007 Apr 17.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats. Miao L, etal., Life Sci 2002 Jul 26;71(10):1175-85.
35. Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Murakoshi H, etal., Nature. 2011 Apr 7;472(7341):100-4. Epub 2011 Mar 20.
36. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. Nagaoka T, etal., J Appl Physiol. 2006 Mar;100(3):996-1002. Epub 2005 Dec 1.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum. O'Kane EM, etal., Brain Res Mol Brain Res 2003 May 26;114(1):1-8.
39. Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK. Patel CA and Rattan S, Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1747-56. Epub 2007 Mar 22.
40. RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease. Peng F, etal., Diabetes. 2008 Jun;57(6):1683-92. Epub 2008 Mar 20.
41. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Phillips HM, etal., Circ Res. 2005 Feb 18;96(3):292-9. Epub 2005 Jan 6.
42. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
43. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Pille JY, etal., Hum Gene Ther. 2006 Oct;17(10):1019-26.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells. Polk WW, etal., Am J Physiol Cell Physiol. 2007 Sep;293(3):C1160-70. Epub 2007 Jul 5.
47. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy. Rangrez AY, etal., J Cell Biol. 2013 Nov 25;203(4):643-56. doi: 10.1083/jcb.201303052.
48. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
49. GOA pipeline RGD automated data pipeline
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors. Rihet S, etal., J Cancer Res Clin Oncol 2001 Dec;127(12):733-8.
52. Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. Saka M, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1164-71.
53. RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation. Sauzeau V, etal., J Biol Chem 2003 Mar 14;278(11):9472-80. Epub 2003 Jan 09.
54. Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. Semenova MM, etal., Nat Neurosci. 2007 Apr;10(4):436-43. Epub 2007 Mar 18.
55. Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration. Su Z, etal., J Cell Sci. 2007 Jun 1;120(Pt 11):1877-87. Epub 2007 May 8.
56. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Takami Y, etal., Dig Dis Sci. 2008 Feb;53(2):467-73. Epub 2007 Jun 28.
57. Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. Tas PW, etal., J Cell Biochem. 2007 Oct 1;102(2):368-76.
58. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Trebicka J, etal., Hepatology. 2007 Jul;46(1):242-53.
59. Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy. Van Linthout S, etal., Diabetologia. 2007 Sep;50(9):1977-86. Epub 2007 Jun 23.
60. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. Varma H, etal., J Biol Chem. 2010 Nov 26;285(48):37445-57. doi: 10.1074/jbc.M110.125542. Epub 2010 Sep 21.
61. Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. Wang Y, etal., Circulation. 2018 Jul 3;138(1):48-63. doi: 10.1161/CIRCULATIONAHA.117.032398. Epub 2018 Feb 16.
62. Distribution and expression of RhoA in rat retina after optic nerve injury. Wang YH, etal., Ophthalmic Res. 2007;39(3):174-8. Epub 2007 May 25.
63. Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Yoshimura S, etal., Brain Res Mol Brain Res 1997 Apr;45(1):90-8.
64. Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways. Zeidan A, etal., J Pharmacol Exp Ther. 2007 Sep;322(3):1110-6. Epub 2007 Jun 11.
65. Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury. Zhang H, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F148-56. Epub 2007 Mar 20.
66. Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons. Zhang Y, etal., Eur J Neurosci. 2007 Mar;25(5):1341-8.
67. Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons. Zhang Y, etal., Pediatr Res. 2007 Jul;62(1):8-13.
68. Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury. Zhang Z, etal., Acta Neuropathol. 2008 Mar;115(3):335-43. Epub 2007 Oct 11.
69. Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis. Zhang Z, etal., J Cell Mol Med. 2007 Jan-Feb;11(1):111-9.
70. Lesional accumulation of RhoA(+) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis. Zhang Z, etal., Neuropathol Appl Neurobiol. 2008 Apr;34(2):231-40. Epub 2007 Nov 5.
71. Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway. Zhao XH, etal., J Cell Sci. 2007 May 15;120(Pt 10):1801-9. Epub 2007 Apr 24.
72. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
73. Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis. Zhou Q, etal., Gut. 2006 Sep;55(9):1296-305. Epub 2006 Feb 21.
Additional References at PubMed
PMID:1328215   PMID:1643657   PMID:8617235   PMID:8625410   PMID:9214622   PMID:10699171   PMID:11877460   PMID:12477932   PMID:12699088   PMID:12706482   PMID:12761501   PMID:12777392  
PMID:12777804   PMID:12816757   PMID:12874183   PMID:12893655   PMID:14614988   PMID:14622110   PMID:14634067   PMID:14657280   PMID:15048014   PMID:15071095   PMID:15093731   PMID:15140945  
PMID:15169791   PMID:15173202   PMID:15192268   PMID:15220352   PMID:15249579   PMID:15308673   PMID:15467718   PMID:15489334   PMID:15513955   PMID:15572519   PMID:15601624   PMID:15607750  
PMID:15644318   PMID:15710384   PMID:15737741   PMID:15798203   PMID:15834419   PMID:15860730   PMID:15870074   PMID:16103226   PMID:16107849   PMID:16160062   PMID:16254014   PMID:16390872  
PMID:16396994   PMID:16449195   PMID:16481321   PMID:16632465   PMID:16787950   PMID:16914531   PMID:17115030   PMID:17136425   PMID:17142836   PMID:17145947   PMID:17234627   PMID:17272518  
PMID:17277021   PMID:17300916   PMID:17334943   PMID:17488780   PMID:17586731   PMID:17661354   PMID:17702745   PMID:17971419   PMID:17996195   PMID:18006472   PMID:18250367   PMID:18316075  
PMID:18332105   PMID:18434385   PMID:18457998   PMID:18469113   PMID:18474218   PMID:18556119   PMID:18562481   PMID:18599801   PMID:18614015   PMID:18621909   PMID:18625710   PMID:18667438  
PMID:18765661   PMID:18824598   PMID:18829532   PMID:18854312   PMID:18981818   PMID:19027829   PMID:19056867   PMID:19085564   PMID:19122172   PMID:19147496   PMID:19209406   PMID:19289122  
PMID:19331812   PMID:19340932   PMID:19524873   PMID:19605563   PMID:19629561   PMID:19635168   PMID:19692654   PMID:19716825   PMID:19723805   PMID:19734146   PMID:19747063   PMID:19755152  
PMID:19759375   PMID:19782033   PMID:19787194   PMID:19799911   PMID:19887681   PMID:19897743   PMID:19934221   PMID:19956681   PMID:20086008   PMID:20139061   PMID:20208559   PMID:20368814  
PMID:20369389   PMID:20380579   PMID:20387077   PMID:20435455   PMID:20442409   PMID:20458337   PMID:20472763   PMID:20507639   PMID:20599954   PMID:20696841   PMID:20807316   PMID:20970835  
PMID:20974804   PMID:20978008   PMID:21131638   PMID:21147877   PMID:21187345   PMID:21411727   PMID:21423176   PMID:21454546   PMID:21511701   PMID:21525037   PMID:21543326   PMID:21545816  
PMID:21572420   PMID:21584655   PMID:21647708   PMID:21676004   PMID:21816966   PMID:21935930   PMID:21946234   PMID:21956892   PMID:21976490   PMID:21978755   PMID:22019888   PMID:22136148  
PMID:22152812   PMID:22275376   PMID:22405202   PMID:22411227   PMID:22427691   PMID:22433866   PMID:22498718   PMID:22685604   PMID:22727353   PMID:22740689   PMID:22865386   PMID:22891260  
PMID:22926577   PMID:22986787   PMID:22987919   PMID:23012358   PMID:23237297   PMID:23241886   PMID:23258382   PMID:23269647   PMID:23325464   PMID:23361995   PMID:23376485   PMID:23413252  
PMID:23457552   PMID:23484083   PMID:23536606   PMID:23564082   PMID:23624614   PMID:23696743   PMID:23726972   PMID:23918799   PMID:24096734   PMID:24292258   PMID:24335996   PMID:24352656  
PMID:24625528   PMID:24637663   PMID:24660528   PMID:24742984   PMID:24872317   PMID:24984203   PMID:25106095   PMID:25121106   PMID:25261755   PMID:25268128   PMID:25318874   PMID:25398325  
PMID:25485583   PMID:25499974   PMID:25502873   PMID:25515214   PMID:25712270   PMID:25783350   PMID:25794483   PMID:25807302   PMID:25911094   PMID:25922200   PMID:26191148   PMID:26350504  
PMID:26391686   PMID:26392029   PMID:26529257   PMID:26572638   PMID:26787017   PMID:26820678   PMID:26846716   PMID:27003208   PMID:27093550   PMID:27094551   PMID:27126736   PMID:27288754  
PMID:27336844   PMID:27693126   PMID:27734223   PMID:27842221   PMID:27917469   PMID:28054559   PMID:28078487   PMID:28235057   PMID:28277985   PMID:28526517   PMID:28665545   PMID:28673614  
PMID:29029794   PMID:29070491   PMID:29522098   PMID:29791873   PMID:29940159   PMID:29953931   PMID:29991018   PMID:30790506   PMID:31029634   PMID:31173168   PMID:31570889   PMID:31963385  
PMID:32386193   PMID:32432762   PMID:32779334   PMID:32813542   PMID:33145656   PMID:34440696   PMID:34840974   PMID:35728732   PMID:35760846   PMID:36579844   PMID:36766714   PMID:36780962  
PMID:37003483   PMID:37458218   PMID:37864185  


Genomics

Comparative Map Data
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,870,548 - 117,904,303 (+)NCBIGRCr8
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,643,315 - 114,651,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,842,642 - 112,851,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,685,281 - 110,693,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBIT2T-CHM13v2.0
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)EnsemblGRCm39 Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBIMGSCv36mm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,336,475 - 49,394,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,341,246 - 49,398,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,180,768 - 40,244,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBIUU_Cfam_GSD_1.0
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,239,560 - 64,285,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529999,935 - 1,045,681 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,834 - 31,986,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,205,022 - 156,258,776 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhoa
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:94
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000071664
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
Arha2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,720,706 - 19,721,410 (+)MAPPERmRatBN7.2
Rnor_6.0X19,913,673 - 19,914,376NCBIRnor6.0
Rnor_5.0X20,664,754 - 20,665,457UniSTSRnor5.0
RGSC_v3.4X40,043,445 - 40,044,148UniSTSRGSC3.4
CeleraX19,980,633 - 19,981,336UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map16q12.5UniSTS
WI-18922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,491 - 109,025,637 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,990 - 117,116,135NCBIRnor6.0
Rnor_5.08116,464,678 - 116,464,823UniSTSRnor5.0
Celera8108,328,407 - 108,328,552UniSTS
Cytogenetic Map16q12.5UniSTS
D3S1330E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,162 - 109,025,271 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,661 - 117,115,769NCBIRnor6.0
Rnor_5.08116,464,349 - 116,464,457UniSTSRnor5.0
Celera8108,328,078 - 108,328,186UniSTS
Cytogenetic Map16q12.5UniSTS
UniSTS:532286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,025,304 - 109,025,687 (+)MAPPERmRatBN7.2
Rnor_6.08117,115,803 - 117,116,185NCBIRnor6.0
Rnor_5.08116,464,491 - 116,464,873UniSTSRnor5.0
Celera8108,328,220 - 108,328,602UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 57 41 19 41 8 11 74 35 41 8 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY026068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY026069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000071664   ⟹   ENSRNOP00000066672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)Ensembl
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094929   ⟹   ENSRNOP00000091658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,992,007 - 109,025,746 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113080   ⟹   ENSRNOP00000091486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,992,007 - 109,025,071 (+)Ensembl
RefSeq Acc Id: NM_057132   ⟹   NP_476473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,894,636 - 117,903,228 (+)NCBI
mRatBN7.28109,016,076 - 109,024,671 (+)NCBI
Rnor_6.08117,106,577 - 117,115,169 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Celera8108,319,010 - 108,327,586 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243699   ⟹   XP_006243761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
mRatBN7.28108,991,926 - 109,025,746 (+)NCBI
Rnor_6.08117,082,440 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243700   ⟹   XP_006243762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
mRatBN7.28108,991,970 - 109,025,396 (+)NCBI
Rnor_6.08117,082,469 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243701   ⟹   XP_006243763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,871,073 - 117,904,303 (+)NCBI
mRatBN7.28108,992,363 - 109,025,746 (+)NCBI
Rnor_6.08117,082,869 - 117,116,244 (+)NCBI
Rnor_5.08116,431,244 - 116,464,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080714   ⟹   XP_038936642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,871,073 - 117,904,303 (+)NCBI
mRatBN7.28108,992,457 - 109,025,746 (+)NCBI
RefSeq Acc Id: XM_063264786   ⟹   XP_063120856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264787   ⟹   XP_063120857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264788   ⟹   XP_063120858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264789   ⟹   XP_063120859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264790   ⟹   XP_063120860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,870,548 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264791   ⟹   XP_063120861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,871,073 - 117,904,303 (+)NCBI
RefSeq Acc Id: XM_063264792   ⟹   XP_063120862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,871,073 - 117,904,303 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476473   ⟸   NM_057132
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL),   A0A8I6AFP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243761   ⟸   XM_006243699
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL),   A0A8I6AFP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243762   ⟸   XM_006243700
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL),   A0A8I6AFP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243763   ⟸   XM_006243701
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL),   A0A8I6AFP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066672   ⟸   ENSRNOT00000071664
RefSeq Acc Id: XP_038936642   ⟸   XM_039080714
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL),   A0A8I6AFP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091658   ⟸   ENSRNOT00000094929
RefSeq Acc Id: ENSRNOP00000091486   ⟸   ENSRNOT00000113080
RefSeq Acc Id: XP_063120860   ⟸   XM_063264790
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120859   ⟸   XM_063264789
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120856   ⟸   XM_063264786
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120858   ⟸   XM_063264788
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120857   ⟸   XM_063264787
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120862   ⟸   XM_063264792
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120861   ⟸   XM_063264791
- Peptide Label: isoform X1
- UniProtKB: P61589 (UniProtKB/Swiss-Prot),   A6I347 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61589-F1-model_v2 AlphaFold P61589 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696296
Promoter ID:EPDNEW_R6820
Type:single initiation site
Name:Rhoa_1
Description:ras homolog family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,106,673 - 117,106,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619921 AgrOrtholog
BioCyc Gene G2FUF-29150 BioCyc
Ensembl Genes ENSRNOG00000050519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013477 UniProtKB/Swiss-Prot
  ENSRNOG00060022827 UniProtKB/Swiss-Prot
  ENSRNOG00065006590 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071664.3 UniProtKB/TrEMBL
  ENSRNOT00000094929.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113080.1 UniProtKB/TrEMBL
  ENSRNOT00055023109 UniProtKB/Swiss-Prot
  ENSRNOT00060039667 UniProtKB/Swiss-Prot
  ENSRNOT00065010200 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598621 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117273 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72339 IMAGE-MGC_LOAD
NCBI Gene 117273 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMING PROTEIN RHOA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhoa PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050519 RatGTEx
  ENSRNOG00055013477 RatGTEx
  ENSRNOG00060022827 RatGTEx
  ENSRNOG00065006590 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AFP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QZ13_RAT UniProtKB/TrEMBL
  A6I347 ENTREZGENE, UniProtKB/TrEMBL
  O35791_RAT UniProtKB/TrEMBL
  P61589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-12 Rhoa  ras homolog family member A  Rhoa  ras homolog gene family, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rhoa  ras homolog gene family, member A      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Rhoa  ras homolog gene family, member A      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-02-25   ras homolog gene family, member A  Rhoa  plysia ras-related homolog A2  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Rhoa  plysia ras-related homolog A2  Arha2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Arha2  plysia ras-related homolog A2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease be involved in the cerebral vascular pathogenesis 632250
gene_expression expressed in 804G rat bladder carcinoma cells 628348
gene_process decreases both expression levels and activities of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642
gene_process regulates actin cytoskeleton 628348
gene_regulation transiently activated by the CNF1 toxin produced by uropathogenic Escherichia coli (UPEC) strains; this restricted activation is a direct consequence of the cell-mediated degradation of the toxin-activated forms 628348
gene_regulation expression level modulated by release of NO in vascular smooth muscle cells 1304269