GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rhoa | multiple interactions | EXP | | 6480464 | CTD | Atorvastatin inhibits the reaction [Streptozocin results in increased activity of RHOA protein] | PMID:17589825 | Rhoa | decreases activity | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Atorvastatin results in decreased activity of RHOA protein | PMID:16470222 | Rhoa | decreases localization | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Atorvastatin results in decreased localization of RHOA protein | PMID:18172863 | Rhoa | increases expression | ISO | RHOA (Homo sapiens) | 6480464 | CTD | Atorvastatin results in increased expression of RHOA protein | PMID:18172863 | Rhoa | multiple interactions | ISO | RHOA (Homo sapiens) | 6480464 | CTD | [Poly I-C co-treated with Atorvastatin co-treated with Ivermectin] results in increased expression of RHOA mRNA; [Poly I-C co-treated with Atorvastatin] results in increased expression of RHOA mRNA; Atorvastatin results in increased localization of and results in decreased prenylation of RHOA protein; Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; RHOA protein inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein] | PMID:16470222 PMID:18172863 PMID:34696514 | | ||||||||||||||||||||||
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